The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Interplay between antibacterial effectors: A macrophage antimicrobial peptide impairs intracellular Salmonella replication
Open accessAbstract
Antimicrobial peptides have established an important role in the defense against extracellular infections, but the expression of cationic peptides within macrophages as an antibacterial effector mechanism against intracellular pathogens has not been demonstrated. Macrophage expression of the murine cathelicidin-related antimicrobial peptide (CRAMP) was increased after infection by the intracellular pathogen Salmonella typhimurium , and this increase required reactive oxygen intermediates. By using CRAMP-deficient mice or synthetic CRAMP peptide, we found that CRAMP impaired Salmonella cell division in vivo and in vitro , resulting in long filamentous bacteria. This impaired bacterial cell division also depended on intracellular elastase-like serine protease activity, which can proteolytically activate cathelicidins. Macrophage serine protease activity induced filamentation and enhanced the activity of CRAMP in vitro . A peptide-sensitive Salmonella mutant showed enhanced survival within macrophages derived from CRAMP-deficient mice, indicating that Salmonella can sense and respond to cationic peptides in the intracellular environment. Although cationic peptides have been hypothesized to have activity against pathogens within macrophages, this work provides experimental evidence that the antimicrobial arsenal of macrophages includes cathelicidins. These results show that intracellular reactive oxygen intermediates and proteases regulate macrophage CRAMP expression and activity to impair the replication of an intracellular bacterial pathogen, and they highlight the cooperativity between macrophage antibacterial effectors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationInnate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citationKilling activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
Vazquez-Torres, A., Jones-Carson, J., Mastroeni, P., Ischiropoulos, H., & Fang, F. C. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.227 · Cited by 530
Richter-Dahlfors, A., Buchan, A. M. J., & Finlay, B. B. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.569 · Cited by 502
Self-citationDeficiency of antibacterial peptides in patients with morbus Kostmann: an observation study
Pütsep, K., Carlsson, G., Boman, H. G., & Andersson, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11201-3 · Cited by 499
Degradation of Outer Membrane Protein A in Escherichia coli Killing by Neutrophil Elastase
Belaaouaj, A. A., Kim, K. S., & Shapiro, S. D. (2000) · Science · doi:10.1126/science.289.5482.1185 · Cited by 363
Cole, A. M., Shi, J., Ceccarelli, A., Kim, Y.-H., Park, A., & Ganz, T. (2001) · Blood · doi:10.1182/blood.v97.1.297 · Cited by 146
Rosenberger, C. M., & Finlay, B. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110649200 · Cited by 100
Self-citation
Cited by
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Yamasaki, K., Di Nardo, A., Bardan, A., Murakami, M., Ohtake, T., Coda, A., Dorschner, R. A., Bonnart, C., Descargues, P., Hovnanian, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1616 · Cited by 852
Self-citationSalmonellae interplay with host cells
Haraga, A., Ohlson, M. B., & Miller, S. I. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1788 · Cited by 832
Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase
Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U., Xu, W., Klevit, R. E., Le Moual, H., & Miller, S. I. (2005) · Cell · doi:10.1016/j.cell.2005.05.030 · Cited by 567
Kallikrein‐mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin
Yamasaki, K., Schauber, J., Coda, A., Lin, H., Dorschner, R. A., Schechter, N. M., Bonnart, C., Descargues, P., Hovnanian, A., & Gallo, R. L. (2006) · The FASEB Journal · doi:10.1096/fj.06-6075com · Cited by 462
Self-citationHow does the oxidative burst of macrophages kill bacteria? Still an open question
Slauch, J. M. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07612.x · Cited by 436
Metadata
- Authors
- Rosenberger, C. M., Gallo, R. L., & Finlay, B. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-11
- Volume
- 101
- Issue
- 8
- Pages
- 2422-2427
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043639065
- Cited by
- 244
- References
- 9
- FWCI
- 18.91
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Interplay between antibacterial effectors: A macrophage antimicrobial peptide impairs intracellular Salmonella replication. https://app.cochat.ai/papers/10.1073/pnas.0304455101
- The paper
- Rosenberger, C. M., Gallo, R. L., & Finlay, B. B. (2004). Interplay between antibacterial effectors: A macrophage antimicrobial peptide impairs intracellular Salmonella replication. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0304455101
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
