The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
Open accessAbstract
The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress, integrin-dependent cell migration, T cell activation, and the Ras pathway in Drosophila . To clarify the in vivo role of NFAT5, we generated NFAT5-null mice. Homozygous mutants were genetically underrepresented after embryonic day 14.5. Surviving mice manifested a progressive and profound atrophy of the kidney medulla with impaired activation of several osmoprotective genes, including those encoding aldose reductase, Na + /Cl – -coupled betaine/γ-aminobutyric acid transporter, and the Na + /myo-inositol cotransporter. The aldose reductase gene is controlled by a tonicity-responsive enhancer, which was refractory to hypertonic stress in fibroblasts lacking NFAT5, establishing this enhancer as a direct transcriptional target of NFAT5. Our findings demonstrate a central role for NFAT5 as a tonicity-responsive transcription factor required for kidney homeostasis and function.
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Physiology of cell volume regulation in vertebrates
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
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Self-citationEpidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
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Direct ionic stress sensing and mitigation by the transcription factor NFAT5
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Metadata
- Authors
- López-Rodríguez, C., Antos, C. L., Shelton, J. M., Richardson, J. A., Lin, F., Novobrantseva, T. I., Bronson, R. T., Igarashi, P., Rao, A., & Olson, E. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-17
- Volume
- 101
- Issue
- 8
- Pages
- 2392-2397
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2045556698
- Cited by
- 278
- References
- 19
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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- López-Rodríguez, C., Antos, C. L., Shelton, J. M., Richardson, J. A., Lin, F., Novobrantseva, T. I., Bronson, R. T., Igarashi, P., Rao, A., & Olson, E. N. (2004). Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308703100
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