The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia
Open accessAbstract
Mammalian airways protect themselves from bacterial infection by using multiple defense mechanisms including antimicrobial peptides, mucociliary clearance, and phagocytic cells. We asked whether airways might also target a key bacterial cell-cell communication system, quorum-sensing. The opportunistic pathogen Pseudomonas aeruginosa uses two quorum-sensing molecules, N -(3-oxododecanoyl)- l -homoserine lactone (3OC12-HSL) and N -butanoyl- l -homoserine lactone (C4-HSL), to control production of extracellular virulence factors and biofilm formation. We found that differentiated human airway epithelia inactivated 3OC12-HSL. Inactivation was selective for acyl-HSLs with certain acyl side chains, and C4-HSL was not inactivated. In addition, the capacity for inactivation varied widely in different cell types. 3OC12-HSL was inactivated by a cell-associated activity rather than a secreted factor. These data suggest that the ability of human airway epithelia to inactivate quorum-sensing signal molecules could play a role in the innate defense against bacterial infection.
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Self-citationDefensins: antimicrobial peptides of innate immunity
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Quorum-sensing in Gram-negative bacteria
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Self-citationAntibacterial peptides: basic facts and emerging concepts
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Self-citationBacterial Quorum Sensing in Pathogenic Relationships
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Self-citationQuenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
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Cited by
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
Hogan, D. A., Vik, Å., & Kolter, R. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04349.x · Cited by 575
Molecular communication in the rhizosphere
Faure, D., Vereecke, D., & Leveau, J. H. J. (2009) · Plant and Soil · doi:10.1007/s11104-008-9839-2 · Cited by 199
Bacterial biofilm in upper respiratory tract infections
Morris, D. P. (2007) · Current Infectious Disease Reports · doi:10.1007/s11908-007-0030-3 · Cited by 37
Nakagami, G., Morohoshi, T., Ikeda, T., Ohta, Y., Sagara, H., Huang, L., Nagase, T., Sugama, J., & Sanada, H. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00653.x · Cited by 34
Metadata
- Authors
- Chun, C. K., Ozer, E. A., Welsh, M. J., Zabner, J., & Greenberg, E. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-17
- Volume
- 101
- Issue
- 10
- Pages
- 3587-3590
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1674929086
- Cited by
- 290
- References
- 36
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Chun, C. K., Ozer, E. A., Welsh, M. J., Zabner, J., & Greenberg, E. P. (2004). Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308750101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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