Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322 · see citing works

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320 · see citing works

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 830 · see citing works

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works

Radiosensitivity in ataxia-telangiectasia: a new explanation.

Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 794 · see citing works

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

Katou, Y., Kanoh, Y., Bando, M., Noguchi, H., Tanaka, H., Ashikari, T., Sugimoto, K., & Shirahige, K. (2003) · Nature · doi:10.1038/nature01900 · Cited by 649 · see citing works

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601 · see citing works

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578 · see citing works

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 540 · see citing works

Mrc1 transduces signals of DNA replication stress to activate Rad53

Alcasabas, A. A., Osborn, A. J., Bachant, J., Hu, F., Werler, P., Bousset, K., Furuya, K., Diffley, J. F. X., Carr, A. M., & Elledge, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-958 · Cited by 516 · see citing works

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M. K., Cowan, K. H., & Brody, L. C. (2002) · Nature Genetics · doi:10.1038/ng837 · Cited by 483 · see citing works

Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation

Xu, B., Kim, S., Lim, D., & Kastan, M. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1049-1059.2002 · Cited by 470 · see citing works

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 459 · see citing works

A unified view of the DNA-damage checkpoint

Melo, J. A., & Toczyski, D. P. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00312-5 · Cited by 457 · see citing works

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430 · see citing works

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in <i>Xenopus</i> egg extracts

Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes &amp; Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53Preprint

Osborn, A. J., & Elledge, S. J. (2003) · Genes & Development · doi:10.1101/gad.1098303 · Cited by 371 · see citing works

Checking on the fork: the DNA-replication stress-response pathway

Osborn, A. J., Elledge, S. J., & Zou, L. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02380-2 · Cited by 345 · see citing works

SCF^β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S. J., & Harper, J. W. (2003) · Genes &amp; Development · doi:10.1101/gad.1157503 · Cited by 340 · see citing works

Human Claspin Is Required for Replication Checkpoint Control

Chini, C. C. S., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301136200 · Cited by 244 · see citing works

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1

Tanaka, K., & Russell, P. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-966 · Cited by 239 · see citing works

Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17

Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

Kumagai, A., & Dunphy, W. G. (2003) · Nature Cell Biology · doi:10.1038/ncb921 · Cited by 172 · see citing works

DNA damage: Chk1 and Cdc25, more than meets the eye

Walworth, N. C. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00160-x · Cited by 60 · see citing works

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836 · see citing works

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 743 · see citing works

Initiating Cellular Stress Responses

Bakkenist, C. J., & Kastan, M. B. (2004) · Cell · doi:10.1016/j.cell.2004.06.023 · Cited by 544 · see citing works

Eukaryotic Chromosome DNA Replication: Where, When, and How?

Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., & Oda, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.103205 · Cited by 494 · see citing works

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

Bassermann, F., Frescas, D., Guardavaccaro, D., Busino, L., Peschiaroli, A., & Pagano, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.043 · Cited by 397 · see citing works

A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response

Zhang, D., Zaugg, K., Mak, T. W., & Elledge, S. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.039 · Cited by 325 · see citing works

Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors

Do, K. T., Wilsker, D. F., Ji, J. J., Zlott, J., Freshwater, T., Kinders, R. J., Collins, J. M., Chen, A. P., Doroshow, J. H., & Kummar, S. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.60.4009 · Cited by 322 · see citing works

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E., & Pagano, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.013 · Cited by 289 · see citing works

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 281 · see citing works

Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

Mailand, N., Bekker-Jensen, S., Bartek, J., & Lukas, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.016 · Cited by 258 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

Ünsal-Kaçmaz, K., Chastain, P. D., Qu, P.-P., Minoo, P., Cordeiro-Stone, M., Sancar, A., & Kaufmann, W. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02190-06 · Cited by 240 · see citing works

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

Traven, A., & Heierhorst, J. (2005) · BioEssays · doi:10.1002/bies.20204 · Cited by 207 · see citing works

DNA replication and progression through S phase

Takeda, D. Y., & Dutta, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208616 · Cited by 193 · see citing works

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

Yazinski, S. A., & Zou, L. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-121658 · Cited by 173 · see citing works

Evidence That the ATR/Chk1 Pathway Maintains Normal Replication Fork Progression during Unperturbed S Phase

Petermann, E., & Caldecott, K. W. (2006) · Cell Cycle · doi:10.4161/cc.5.19.3256 · Cited by 163 · see citing works

Mechanisms of replication fork protection: a safeguard for genome stability

Errico, A., & Costanzo, V. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.655374 · Cited by 159 · see citing works

The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor−/Progesterone Receptor−/HER-2− Breast Carcinomas

Verlinden, L., Bempt, I. V., Eelen, G., Drijkoningen, M., Verlinden, I., Marchal, K., Wolf‐Peeters, C. D., Christiaens, M.-R., Michiels, L., Bouillon, R., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3545 · Cited by 149 · see citing works

Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway

Wang, X., Kennedy, R. D., Ray, K., Stuckert, P., Ellenberger, T., & D’Andrea, A. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02357-06 · Cited by 147 · see citing works

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Bianco, J. N., Bergoglio, V., Lin, Y., Pillaire, M., Schmitz, A.-L., Gilhodes, J., Lusque, A., Mazières, J., Lacroix‐Triki, M., Roumeliotis, T. I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08886-8 · Cited by 146 · see citing works

Maintenance of fork integrity at damaged DNA and natural pause sites

Tourrière, H., & Pasero, P. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.004 · Cited by 140 · see citing works

Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress

Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K. E., Hittelman, W. N., Elledge, S. J., & Li, L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.022 · Cited by 135 · see citing works

Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint

Yoshizawa-Sugata, N., & Masai, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605596200 · Cited by 127 · see citing works

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

Kemp, M. G., Akan, Z., Yilmaz, S., Grillo, M., Smith‐Roe, S. L., Kang, T., Cordeiro‐Stone, M., Kaufmann, W. K., Abraham, R. T., Sancar, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110304 · Cited by 120 · see citing works

Claspin Promotes Normal Replication Fork Rates in Human Cells

Petermann, E., Helleday, T., & Caldecott, K. W. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1035 · Cited by 116 · see citing works

Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells

Li, L., & Zou, L. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20355 · Cited by 114 · see citing works

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

Clarke, C., & Clarke, P. R. (2005) · Biochemical Journal · doi:10.1042/bj20041966 · Cited by 108 · see citing works

Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis

Richard, D. J., Bolderson, E., & Khanna, K. K. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230902849180 · Cited by 106 · see citing works

Human Papillomavirus 16 E7 Oncoprotein Attenuates DNA Damage Checkpoint Control by Increasing the Proteolytic Turnover of Claspin

Spardy, N. A., Covella, K., Cha, E., Hoskins, E. E., Wells, S. I., Duensing, A. U., & Duensing, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0925 · Cited by 104 · see citing works

Targeting deubiquitinase USP28 for cancer therapy

Wang, X., Liu, Z., Zhang, L., Yang, Z., Chen, X., Luo, J., Zhou, Z., Mei, X., Yu, X., Shao, Z., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0208-z · Cited by 102 · see citing works

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint

Kim, J. M., Kakusho, N., Yamada, M., Kanoh, Y., Takemoto, N., & Masai, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210994 · Cited by 98 · see citing works

Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival

Zangen, I. L.-V., Kneitz, S., Monoranu, C., Rutkowski, S., Hinkes, B. G., Vince, G. H., Huang, B., & Roggendorf, W. (2007) · Acta Neuropathologica · doi:10.1007/s00401-006-0190-5 · Cited by 94 · see citing works

Phosphatases in the cellular response to DNA damage

Freeman, A. K., & Monteiro, Á. N. A. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-27 · Cited by 93 · see citing works

Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in <i>Xenopus</i> egg extracts

Errico, A., Costanzo, V., & Hunt, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706347104 · Cited by 92 · see citing works

Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures

Sar, F., Lindsey‐Boltz, L. A., Subramanian, D., Croteau, D. L., Hutsell, S. Q., Griffith, J. D., & Sancar, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405793200 · Cited by 84 · see citing works

Viral and cellular interactions during adenovirus DNA replication

Charman, M., Herrmann, C., & Weitzman, M. D. (2019) · FEBS Letters · doi:10.1002/1873-3468.13695 · Cited by 80 · see citing works

Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function

Chini, C. C. S., & Chen, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604373200 · Cited by 78 · see citing works

DNA Structure and Integrity Checkpoints during the Cell Cycle and Their Role in Drug Targeting and Sensitivity of Tumor Cells to Anticancer Treatment

Składanowski, A., Bozko, P. M., & Sabisz, M. (2009) · Chemical Reviews · doi:10.1021/cr900026u · Cited by 71 · see citing works

Checkpoint adaptation in human cells

Syljuåsen, R. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210402 · Cited by 71 · see citing works

Roles of Replication Fork-interacting and Chk1-activating Domains from Claspin in a DNA Replication Checkpoint Response

Lee, J., Gold, D. A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0671 · Cited by 70 · see citing works

The S phase checkpoint: When the crowd meets at the fork

Gottifredi, V., & Prives, C. L. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.02.011 · Cited by 68 · see citing works

Identifying Host Factors Associated with DNA Replicated During Virus Infection

Reyes, E. D., Kulej, K., Pancholi, N. J., Akhtar, L. N., Avgousti, D. C., Kim, E. T., Bricker, D. K., Spruce, L. A., Koniski, S. A., Seeholzer, S. H., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m117.067116 · Cited by 67 · see citing works

HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability

Zhu, M., Zhao, H., Liao, J., & Xu, X. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku978 · Cited by 66 · see citing works

A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair

Sato, K., Sundaramoorthy, E., Rajendra, E., Hattori, H., Jeyasekharan, A. D. D., Ayoub, N., Schiess, R., Aebersold, R. H., Nishikawa, H., Sedukhina, A. S., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.034 · Cited by 65 · see citing works

Chk1 is required to maintain Claspin stability

Chini, C. C. S., Wood, J., & Chen, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209447 · Cited by 62 · see citing works

A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition

Gill, M. R., Harun, S. N., Halder, S., Boghozian, R. A., Ramadan, K., Ahmad, H., & Vallis, K. A. (2016) · Scientific Reports · doi:10.1038/srep31973 · Cited by 58 · see citing works

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresPreprint

Yoo, H. Y., Jeong, S., & Dunphy, W. G. (2006) · Genes & Development · doi:10.1101/gad.1398806 · Cited by 58 · see citing works

Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase

Lindsey‐Boltz, L. A., Serçin, Ö., Choi, J.-H., & Sancar, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064485 · Cited by 55 · see citing works

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase

McGarry, E., Gaboriau, D. C. A., Rainey, M. D., Restuccia, U., Bachi, A., & Santocanale, C. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2890 · Cited by 54 · see citing works

Spy1 Expression Prevents Normal Cellular Responses to DNA Damage

Gastwirt, R. F., Slavin, D. A., McAndrew, C. W., & Donoghue, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604720200 · Cited by 52 · see citing works

The BRCA1 ubiquitin ligase and homologous recombination repair

Ohta, T., Sato, K., & Wu, W. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.005 · Cited by 52 · see citing works

The human intra-S checkpoint response to UVC-induced DNA damage

Kaufmann, W. K. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp230 · Cited by 52 · see citing works

The BRCA1/BARD1 ubiquitin ligase and its substrates

Witus, S. R., Stewart, M. D., & Klevit, R. E. (2021) · Biochemical Journal · doi:10.1042/bcj20200864 · Cited by 52 · see citing works

Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer’s Disease

Wężyk, M., Szybińska, A., Wojsiat, J., Szczerba, M., Day, K., Rönnholm, H., Kele, M., Berdyński, M., Pepłońska, B., Fichna, J. P., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170830 · Cited by 51 · see citing works

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Yang, C.-C., Suzuki, M., Yamakawa, S., Uno, S., Ishii, A., Yamazaki, S., Fukatsu, R., Fujisawa, R., Sakimura, K., Tsurimoto, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms12135 · Cited by 50 · see citing works

Fanconi anemia proteins and endogenous stresses

Pang, Q., & Andreassen, P. R. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.03.013 · Cited by 49 · see citing works

The Protective Role of Dormant Origins in Response to Replicative Stress

Courtot, L., Hoffmann, J., & Bergoglio, V. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113569 · Cited by 48 · see citing works

BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

Tian, F., Sharma, S., Zou, J., Lin, S., Wang, B., Rezvani, K. S., Wang, H., Parvin, J. D., Ludwig, T., Canman, C. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306534110 · Cited by 47 · see citing works

Cleavage of Claspin by Caspase-7 during Apoptosis Inhibits the Chk1 Pathway

Clarke, C., Bennett, L. N., & Clarke, P. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506460200 · Cited by 46 · see citing works

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 45 · see citing works

Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome

Semple, J. I., Smits, V. A. J., Hernandez-Fernaud, J. R., Mamely, I., & Freire, R. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402134 · Cited by 45 · see citing works

HERC2 Interacts with Claspin and Regulates DNA Origin Firing and Replication Fork Progression

Izawa, N., Wu, W., Sato, K., Nishikawa, H., Kato, A., Boku, N., Itoh, F., & Ohta, T. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0385 · Cited by 45 · see citing works

Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages

Kamimura, K., Mishima, Y., Obata, M., Endo, T., Aoyagi, Y., & Kominami, R. (2007) · Oncogene · doi:10.1038/sj.onc.1210388 · Cited by 44 · see citing works

Claspin functions in cell homeostasis—A link to cancer?

Azenha, D., Lopes, M. C., & Martins, T. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.09.002 · Cited by 43 · see citing works

Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells

Yang, C.-C., Kato, H., Shindo, M., & Masai, H. (2019) · eLife · doi:10.7554/elife.50796 · Cited by 43 · see citing works

Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1

Meng, Z., Capalbo, L., Glover, D. M., & Dunphy, W. G. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-01-0048 · Cited by 41 · see citing works

CtIP, a candidate tumor susceptibility gene is a team player with luminaries

Chinnadurai, G. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.09.002 · Cited by 41 · see citing works

CRL Ubiquitin Ligases and DNA Damage Response

Li, J.-M., & Jin, J. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00029 · Cited by 41 · see citing works

Regulation of Claspin degradation by the ubiquitin‐proteosome pathway during the cell cycle and in response to ATR‐dependent checkpoint activation

Bennett, L. N., & Clarke, P. R. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.071 · Cited by 39 · see citing works

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

Rainey, M. D., Harhen, B., Wang, G., Murphy, P. V., & Santocanale, C. (2013) · Cell Cycle · doi:10.4161/cc.24675 · Cited by 37 · see citing works

Claspin overexpression is associated with high‐grade histology and poor prognosis in renal cell carcinoma

Kobayashi, G., Sentani, K., Babasaki, T., Sekino, Y., Shigematsu, Y., Hayashi, T., Oue, N., Teishima, J., Matsubara, A., Sasaki, N., et al. (2020) · Cancer Science · doi:10.1111/cas.14299 · Cited by 36 · see citing works

Evaluation of claspin as a proliferation marker in human cancer and normal tissues

Tsimaratou, K., Kletsas, D., Kastrinakis, N. G., Tsantoulis, P. K., Evangelou, K., Sideridou, M., Liontos, M., Poulias, I., Venere, M., Salmas, M., et al. (2006) · The Journal of Pathology · doi:10.1002/path.2095 · Cited by 35 · see citing works

Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)

Lindsey‐Boltz, L. A., & Sancar, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237958 · Cited by 35 · see citing works

BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance

Kong, Y., Akatsuka, S., Motooka, Y., Zheng, H., Cheng, Z., Shiraki, Y., Mashimo, T., Imaoka, T., & Toyokuni, S. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102356 · Cited by 34 · see citing works

Germline alterations in the CLSPN gene in breast cancer families

Erkko, H., Pylkäs, K., Karppinen, S., & Winqvist, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2007.11.003 · Cited by 32 · see citing works

The TIMELESS effort for timely DNA replication and protection

Patel, J. A., & Kim, H. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04738-3 · Cited by 30 · see citing works

Characterization of functional domains in human Claspin

Serçin, Ö., & Kemp, M. G. (2011) · Cell Cycle · doi:10.4161/cc.10.10.15562 · Cited by 30 · see citing works

FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses

Zhang, F., Fan, Q., Ren, K., Auerbach, A. D., & Andreassen, P. R. (2010) · Chromosoma · doi:10.1007/s00412-010-0285-6 · Cited by 30 · see citing works

Overexpression of claspin promotes docetaxel resistance and is associated with prostate‐specific antigen recurrence in prostate cancer

Babasaki, T., Sentani, K., Sekino, Y., Kobayashi, G., Phạm, Q. T., Katsuya, N., Akabane, S., Taniyama, D., Hayashi, T., Shiota, M., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4113 · Cited by 29 · see citing works

Clinicopathological significance of claspin overexpression and its efficacy as a novel biomarker for the diagnosis of urothelial carcinoma

Kobayashi, G., Hayashi, T., Sentani, K., Babasaki, T., Sekino, Y., Inoue, S., Uraoka, N., Hanamoto, M., Nose, H., Teishima, J., et al. (2021) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-021-03239-7 · Cited by 29 · see citing works

Molecular Mechanisms of DNA Replication Checkpoint Activation

Recolin, B., van der Laan, S., Tsanov, N., & Maiorano, D. (2014) · Genes · doi:10.3390/genes5010147 · Cited by 29 · see citing works

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Jiao, R., Xu, F., Huang, X., Li, H., Liu, W., Cao, H., Zang, L., Li, Z., Hua, H., & Li, D. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1740696 · Cited by 29 · see citing works

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork

Saldanha, J., Rageul, J., Patel, J. A., & Kim, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310488 · Cited by 26 · see citing works

Clinicopathological significance of claspin overexpression and its association with spheroid formation in gastric cancer

Kobayashi, G., Sentani, K., Hattori, T., Yamamoto, Y., Imai, T., Sakamoto, N., Kuraoka, K., Oue, N., Sasaki, N., Taniyama, K., et al. (2018) · Human Pathology · doi:10.1016/j.humpath.2018.09.001 · Cited by 26 · see citing works

Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle

Buchsbaum, S., Morris, C., Bochard, V., & Jalinot, P. (2007) · Oncogene · doi:10.1038/sj.onc.1210314 · Cited by 26 · see citing works

Role of Claspin in regulation of nucleotide excision repair factor DDB2

Prætorius-Ibba, M., Wang, Q.-E., Wani, G., El-Mahdy, M. A., Zhu, Q., Qin, S., & Wani, A. A. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.009 · Cited by 24 · see citing works

Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin

Zhang, J., Song, Y., Brannigan, B. W., Wahrer, D. C. R., Schiripo, T. A., Harris, P. L., Haserlat, S. M., Ulkus, L. E., Shannon, K., Garber, J. E., et al. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0033 · Cited by 24 · see citing works

The GANT61, a GLI Inhibitor, Induces Caspase-Independent Apoptosis of SK-N-LO Cells

Μatsumoto, T., Tabata, K., & Suzuki, T. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00920 · Cited by 22 · see citing works

Checkpoint and Coordinated Cellular Responses to DNA Damage

Yang, X. H., & Zou, L. (2006) · Springer eBooks · doi:10.1007/b136684 · Cited by 20 · see citing works

Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

Azenha, D., Hernández-Pérez, S., Martín, Y., Viegas, M. S., Martins, A., Lopes, M. C., Lam, E. W. ‐., Freire, R., & Martins, T. (2020) · Cancers · doi:10.3390/cancers12092396 · Cited by 19 · see citing works

The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase ϵ and Stimulates Its Synthetic Activity

Aria, V., Felice, M. D., Perna, R. D., Uno, S., Masai, H., Syväoja, J. E., van Loon, B., Hübscher, U., & Pisani, F. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.398073 · Cited by 19 · see citing works

Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy

Faratian, D., Um, I., Wilson, D. S., Mullen, P., Langdon, S. P., & Harrison, D. J. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.01.014 · Cited by 19 · see citing works

Mammalian DNA Damage Response Pathway

Lou, Z., & Chen, J. (2006) · Springer eBooks · doi:10.1007/1-4020-3764-3_15 · Cited by 19 · see citing works

In my end is my beginning: control of end resection and DSBR pathway ‘choice’ by cyclin-dependent kinases

Scully, R., & Xie, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208609 · Cited by 19 · see citing works

Mrc1/Claspin: a new role for regulation of origin firing

Masai, H., Yang, C.-C., & Matsumoto, S. (2017) · Current Genetics · doi:10.1007/s00294-017-0690-y · Cited by 18 · see citing works

Kv10.1 Regulates Microtubule Dynamics during Mitosis

Movsisyan, N., & Pardo, L. A. (2020) · Cancers · doi:10.3390/cancers12092409 · Cited by 18 · see citing works

Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles

Zhou, L., Qin, B., Yassine, D. M., Luo, M., Liu, X., Wang, F., & Wang, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115624 · Cited by 17 · see citing works

Protein Kinases That Regulate Chromosome Stability and Their Downstream Targets

Nojima, H. (2006) · KARGER eBooks · doi:10.1159/000092505 · Cited by 17 · see citing works

BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells

Draga, M., Madgett, E. B., Vandenberg, C. J., du Plessis, D., Kaufmann, A., Werler, P., Chakraborty, P., Lowndes, N. F., & Hiom, K. J. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01497-14 · Cited by 17 · see citing works

Posttranscriptional control of the replication stress response via TTP-mediated Claspin mRNA stabilization

Lee, T.-H., Choi, J. Y., Park, J., & Kang, T. (2020) · Oncogene · doi:10.1038/s41388-020-1220-9 · Cited by 16 · see citing works

Human Claspin Is Required for Replication Checkpoint Control

Chini, C. C. S., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301136200 · Cited by 244 · see citing works

Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells

Hsiao, H.-W., Yang, C.-C., & Masai, H. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00049-8 · Cited by 20 · see citing works

Claspin – checkpoint adaptor and DNA replication factor

Smits, V. A. J., Cabrera, E., Freire, R., & Gillespie, D. A. (2018) · FEBS Journal · doi:10.1111/febs.14594 · Cited by 97 · see citing works

Claspin, a regulator of Chk1 in DNA replication stress pathway

Chini, C. C. S., & Chen, J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.001 · Cited by 85 · see citing works

Understanding the role of Claspin in DNA damage checkpoints

Sar, F. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/r8wc-5e17