Human Claspin Is Required for Replication Checkpoint Control

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322 · see citing works

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320 · see citing works

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091 · see citing works

Untitled work

(1999) · PubMed · Cited by 1,030 · see citing works

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 830 · see citing works

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Kim, S.-T., Lim, D.-S., Canman, C. E., & Kastan, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37538 · Cited by 810 · see citing works

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 688 · see citing works

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsPreprint

Liu, M., Pereira, F. A., Price, S. D., Chu, M.-J., Shope, C. D., Himes, D., Eatock, R. A., Brownell, W. E., Lysakowski, A., & Tsai, M. (2000) · Genes & Development · doi:10.1101/gad.840500 · Cited by 625 · see citing works

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics &amp; Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601 · see citing works

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 534 · see citing works

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint

Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498 · see citing works

Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− micePreprint

Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., & Nakayama, K. (2000) · Genes & Development · doi:10.1101/gad.14.12.1439 · Cited by 478 · see citing works

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 459 · see citing works

A unified view of the DNA-damage checkpoint

Melo, J. A., & Toczyski, D. P. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00312-5 · Cited by 457 · see citing works

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

de Klein, A., Muijtjens, M., van Os, R. P., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., & Hoeijmakers, J. H. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00447-4 · Cited by 437 · see citing works

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430 · see citing works

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in <i>Xenopus</i> egg extracts

Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes &amp; Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works

Activation of mammalian Chk1 during DNA replication arrest

Feijóo, C. G., Hall-Jackson, C. A., Wu, R., Jenkins, D., Leitch, J., Gilbert, D. M., & Smythe, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104099 · Cited by 318 · see citing works

Untitled work

(2000) · PubMed · Cited by 314 · see citing works

ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161281798 · Cited by 290 · see citing works

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

Heffernan, T. P., Simpson, D. A., Frank, A. R., Heinloth, A. N., Paules, R. S., Cordeiro-Stone, M., & Kaufmann, W. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8552-8561.2002 · Cited by 251 · see citing works

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

Wright, J. A., Keegan, K. S., Herendeen, D. R., Bentley, N. J., Carr, A. M., Hoekstra, M. F., & Concannon, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7445 · Cited by 226 · see citing works

Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17

Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

Hekmat-Nejad, M., You, Z., Yee, M., Newport, J. W., & Cimprich, K. A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00855-1 · Cited by 193 · see citing works

p38 and Chk1 kinases: different conductors for the G2/M checkpoint symphony

Bulavin, D. V. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00270-2 · Cited by 174 · see citing works

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

Kumagai, A., & Dunphy, W. G. (2003) · Nature Cell Biology · doi:10.1038/ncb921 · Cited by 172 · see citing works

Cell cycle-dependent and ATM-independent expression of human Chk1 kinase

Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Terasawa, M., Tachibana, A., Ikeda, K., & Nakanishi, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202706 · Cited by 150 · see citing works

Nuclear Localization and Cell Cycle-specific Expression of CtIP, a Protein That Associates with the BRCA1 Tumor Suppressor

Yu, X., & Baer, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909494199 · Cited by 143 · see citing works

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

Lopez‐Girona, A., Tanaka, K., Chen, X.-B., Baber, B. A., McGowan, C. H., & Russell, P. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191557598 · Cited by 129 · see citing works

The Human Checkpoint Protein hRad17 Interacts with the PCNA-like Proteins hRad1, hHus1, and hRad9

Rauen, M. P., Burtelow, M. A., Dufault, V. M., & Karnitz, L. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005782200 · Cited by 110 · see citing works

Threonine 68 of Chk2 Is Phosphorylated at Sites of DNA Strand Breaks

Ward, I. M., Wu, X., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100587200 · Cited by 108 · see citing works

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint

Nghiem, P., Park, P. K., Kim, Y.-S., Desai, B. N., & Schreiber, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106113200 · Cited by 98 · see citing works

Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway

Weiss, R. S., Matsuoka, S., Elledge, S. J., & Leder, P. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00626-1 · Cited by 91 · see citing works

Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.

Guo, N., Faller, D. V., & Vaziri, C. (2002) · PubMed · Cited by 73 · see citing works

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 743 · see citing works

Eukaryotic Chromosome DNA Replication: Where, When, and How?

Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., & Oda, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.103205 · Cited by 494 · see citing works

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

Zhou, B. S., & Bártek, J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1296 · Cited by 390 · see citing works

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E., & Pagano, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.013 · Cited by 289 · see citing works

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 281 · see citing works

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

Yang, H. J. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg137 · Cited by 275 · see citing works

Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

Mailand, N., Bekker-Jensen, S., Bartek, J., & Lukas, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.016 · Cited by 258 · see citing works

Nucleoside analogs: molecular mechanisms signaling cell death

Ewald, B., Sampath, D., & Plunkett, W. K. (2008) · Oncogene · doi:10.1038/onc.2008.316 · Cited by 246 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

Ünsal-Kaçmaz, K., Chastain, P. D., Qu, P.-P., Minoo, P., Cordeiro-Stone, M., Sancar, A., & Kaufmann, W. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02190-06 · Cited by 240 · see citing works

Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery

Mamely, I., van Vugt, M. A., Smits, V. A., Semple, J. I., Lemmens, B., Perrakis, A., Medema, R. H., & Freire, R. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.026 · Cited by 227 · see citing works

The ubiquitous role of ubiquitin in the DNA damage response

Al-Hakim, A., Escribano‐Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.011 · Cited by 224 · see citing works

Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells

Swift, L. H., & Golsteyn, R. M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033403 · Cited by 214 · see citing works

DNA damage tolerance: a double-edged sword guarding the genome.

Ghosal, G., & Chen, J. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.04.01 · Cited by 204 · see citing works

Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response

Smits, V. A. J., Reaper, P. M., & Jackson, S. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.11.066 · Cited by 199 · see citing works

Chk1 in the DNA damage response: conserved roles from yeasts to mammals

Chen, Y., & Sánchez, Y. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.003 · Cited by 197 · see citing works

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

Shechter, D., Costanzo, V., & Gautier, J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.020 · Cited by 192 · see citing works

Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

Liu, S., Bekker‐Jensen, S., Mailand, N., Lukas, C., Bártek, J., & Lukas, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00492-06 · Cited by 184 · see citing works

Checkpoint control and cancer

Medema, R. H., & Macůrek, L. (2011) · Oncogene · doi:10.1038/onc.2011.451 · Cited by 178 · see citing works

DNA Damage Response in Plants: Conserved and Variable Response Compared to Animals

Yoshiyama, K., Sakaguchi, K., & Kimura, S. (2013) · Biology · doi:10.3390/biology2041338 · Cited by 174 · see citing works

Evidence That the ATR/Chk1 Pathway Maintains Normal Replication Fork Progression during Unperturbed S Phase

Petermann, E., & Caldecott, K. W. (2006) · Cell Cycle · doi:10.4161/cc.5.19.3256 · Cited by 163 · see citing works

Mechanisms of replication fork protection: a safeguard for genome stability

Errico, A., & Costanzo, V. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.655374 · Cited by 159 · see citing works

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Lin, S.-Y., Li, K., Stewart, G. S., & Elledge, S. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401847101 · Cited by 156 · see citing works

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Bianco, J. N., Bergoglio, V., Lin, Y., Pillaire, M., Schmitz, A.-L., Gilhodes, J., Lusque, A., Mazières, J., Lacroix‐Triki, M., Roumeliotis, T. I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08886-8 · Cited by 146 · see citing works

Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells

Matsumoto, M., Yaginuma, K., Igarashi, A., Imura, M., Hasegawa, M., Iwabuchi, K., Date, T., Mori, T., Ishizaki, K., Yamashita, K., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.03391 · Cited by 138 · see citing works

Claspin and the Activated Form of ATR-ATRIP Collaborate in the Activation of Chk1

Kumagai, A., Kim, S.-M., & Dunphy, W. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408353200 · Cited by 138 · see citing works

Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors

Gotter, A. L., Suppa, C., & Emanuel, B. S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.097 · Cited by 135 · see citing works

Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress

Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K. E., Hittelman, W. N., Elledge, S. J., & Li, L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.022 · Cited by 135 · see citing works

Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint

Yoshizawa-Sugata, N., & Masai, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605596200 · Cited by 127 · see citing works

DNA replication as a target of the DNA damage checkpoint

Zegerman, P., & Diffley, J. F. X. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.023 · Cited by 128 · see citing works

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Finn, K., Lowndes, N. F., & Grenon, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0875-3 · Cited by 127 · see citing works

DeepCleave: a deep learning predictor for caspase and matrix metalloprotease substrates and cleavage sites

Li, F., Chen, J.-X., Leier, A., Marquez‐Lago, T. T., Liu, Q., Wang, Y., Revote, J., Smith, A. I., Akutsu, T., Webb, G. I., et al. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz721 · Cited by 127 · see citing works

Recruitment of the Cell Cycle Checkpoint Kinase ATR to Chromatin during S-phase

Dart, D. A., Adams, K. E., Akerman, I., & Lakin, N. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314212200 · Cited by 124 · see citing works

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

Kemp, M. G., Akan, Z., Yilmaz, S., Grillo, M., Smith‐Roe, S. L., Kang, T., Cordeiro‐Stone, M., Kaufmann, W. K., Abraham, R. T., Sancar, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110304 · Cited by 120 · see citing works

Claspin Promotes Normal Replication Fork Rates in Human Cells

Petermann, E., Helleday, T., & Caldecott, K. W. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1035 · Cited by 116 · see citing works

Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells

Li, L., & Zou, L. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20355 · Cited by 114 · see citing works

HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

Collis, S. J., Barber, L. J., Clark, A. J., Martin, J. S., Ward, J. D., & Boulton, S. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1555 · Cited by 112 · see citing works

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

Clarke, C., & Clarke, P. R. (2005) · Biochemical Journal · doi:10.1042/bj20041966 · Cited by 108 · see citing works

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

Leman, A. R., & Noguchi, E. (2013) · Genes · doi:10.3390/genes4010001 · Cited by 102 · see citing works

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint

Kim, J. M., Kakusho, N., Yamada, M., Kanoh, Y., Takemoto, N., & Masai, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210994 · Cited by 98 · see citing works

Claspin – checkpoint adaptor and DNA replication factor

Smits, V. A. J., Cabrera, E., Freire, R., & Gillespie, D. A. (2018) · FEBS Journal · doi:10.1111/febs.14594 · Cited by 97 · see citing works

Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in <i>Xenopus</i> egg extracts

Errico, A., Costanzo, V., & Hunt, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706347104 · Cited by 92 · see citing works

G2 damage checkpoints: what is the turn-on?

O’Connell, M. J., & Cimprich, K. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01626 · Cited by 94 · see citing works

Local and global functions of Timeless and Tipin in replication fork protection

Leman, A. R., & Noguchi, E. (2012) · Cell Cycle · doi:10.4161/cc.21989 · Cited by 92 · see citing works

Phosphatases in the cellular response to DNA damage

Freeman, A. K., & Monteiro, Á. N. A. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-27 · Cited by 93 · see citing works

Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses

Hollingworth, R., & Grand, R. (2015) · Viruses · doi:10.3390/v7052542 · Cited by 90 · see citing works

DNA damage checkpoint recovery and cancer development

Wang, H., Zhang, X., Teng, L., & Legerski, R. J. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.03.011 · Cited by 89 · see citing works

Human CST facilitates genome-wide RAD51 recruitment to GC-rich repetitive sequences in response to replication stress

Chastain, M., Zhou, Q., Shiva, O., Fadri-Moskwik, M., Whitmore, L. S., Jia, P., Dai, X., Huang, C.-H., Ye, P., & Chai, W.-H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.077 · Cited by 79 · see citing works

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Xiao, Z., Xue, J., Sowin, T. J., Rosenberg, S. H., & Zhang, H. (2004) · Oncogene · doi:10.1038/sj.onc.1208309 · Cited by 88 · see citing works

Claspin, a regulator of Chk1 in DNA replication stress pathway

Chini, C. C. S., & Chen, J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.001 · Cited by 85 · see citing works

Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures

Sar, F., Lindsey‐Boltz, L. A., Subramanian, D., Croteau, D. L., Hutsell, S. Q., Griffith, J. D., & Sancar, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405793200 · Cited by 84 · see citing works

Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Sezer, E., Oktay, L. M., Karadadaş, E., Memmedov, H., Günel, N. S., & Sözmen, E. Y. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.0098 · Cited by 89 · see citing works

Phosphorylated Claspin Interacts with a Phosphate-binding Site in the Kinase Domain of Chk1 during ATR-mediated Activation

Jeong, S., Kumagai, A., Lee, J., & Dunphy, W. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304551200 · Cited by 84 · see citing works

Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study

Yuan, J., Sun, C., Dou, T., Yi, G., Qu, L., Qu, L., Wang, K., & Yang, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140615 · Cited by 84 · see citing works

5-ASA Affects Cell Cycle Progression in Colorectal Cells by Reversibly Activating a Replication Checkpoint

Luciani, M. G., Campregher, C., Fortune, J. M., Kunkel, T. A., & Gasché, C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.016 · Cited by 80 · see citing works

Viral and cellular interactions during adenovirus DNA replication

Charman, M., Herrmann, C., & Weitzman, M. D. (2019) · FEBS Letters · doi:10.1002/1873-3468.13695 · Cited by 80 · see citing works

Cdc7-Dbf4 and the Human S Checkpoint Response to UVC

Heffernan, T. P., Ünsal-Kaçmaz, K., Heinloth, A. N., Simpson, D. A., Paules, R. S., Sancar, A., Cordeiro‐Stone, M., & Kaufmann, W. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611292200 · Cited by 78 · see citing works

Cullins and Cancer

Lee, J., & Zhou, P. (2010) · Genes & Cancer · doi:10.1177/1947601910382899 · Cited by 79 · see citing works

Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function

Chini, C. C. S., & Chen, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604373200 · Cited by 78 · see citing works

ATR maintains select progenitors during nervous system development

Lee, Y., Shull, E. R. P., Frappart, P., Katyal, S., Enriquez-Rios, V. D., Zhao, J., Russell, H. R., Brown, E. J., & McKinnon, P. J. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.493 · Cited by 77 · see citing works

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

Liu, Y., Fang, Y., Shao, H., Lindsey-Boltz, L., Sancar, A., & Modrich, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.076109 · Cited by 78 · see citing works

An Essential Role for MCL-1 in ATR-mediated CHK1 Phosphorylation

Jamil, S., Mojtabavi, S., Hojabrpour, P., Cheah, S., & Duronio, V. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-11-1171 · Cited by 77 · see citing works

Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

Mizuarai, S., Yamanaka, K., Itadani, H., Arai, T., Nishibata, T., Hirai, H., & Kotani, H. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-34 · Cited by 72 · see citing works

Viral Transport of DNA Damage That Mimics a Stalled Replication Fork

Jurvansuu, J., Raj, K., Stasiak, A., & Beard, P. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.569-580.2005 · Cited by 71 · see citing works

Roles of Replication Fork-interacting and Chk1-activating Domains from Claspin in a DNA Replication Checkpoint Response

Lee, J., Gold, D. A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0671 · Cited by 70 · see citing works

The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted

Liu, E., Lee, A. Y., Chiba, T., Olson, E. E., Sun, P., & Wu, X. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704138 · Cited by 70 · see citing works

The fork and the kinase: A DNA replication tale from a CHK1 perspective

Besteiro, M. A. G., & Gottifredi, V. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.10.003 · Cited by 71 · see citing works

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

Jamil, S., Stoica, C., Hackett, T., & Duronio, V. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12354 · Cited by 67 · see citing works

Identifying Host Factors Associated with DNA Replicated During Virus Infection

Reyes, E. D., Kulej, K., Pancholi, N. J., Akhtar, L. N., Avgousti, D. C., Kim, E. T., Bricker, D. K., Spruce, L. A., Koniski, S. A., Seeholzer, S. H., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m117.067116 · Cited by 67 · see citing works

Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners

Iwanaga, R., Komori, H., Ishida, S., Okamura, N., Nakayama, K., Nakayama, K., & Ohtani, K. (2005) · Oncogene · doi:10.1038/sj.onc.1209210 · Cited by 69 · see citing works

Sister acts: coordinating DNA replication and cohesion establishmentPreprint

Sherwood, R., Takahashi, T. S., & Jallepalli, P. V. (2010) · Genes & Development · doi:10.1101/gad.1976710 · Cited by 65 · see citing works

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

Hannah, J., & Zhou, P. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.011 · Cited by 63 · see citing works

Poly(ADP-ribose) Polymerase Activity Prevents Signaling Pathways for Cell Cycle Arrest after DNA Methylating Agent Exposure

Horton, J. K., Stefanick, D. F., Naron, J. M., Kedar, P. S., & Wilson, S. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413841200 · Cited by 63 · see citing works

Replication Checkpoint Protein Mrc1 Is Regulated by Rad3 and Tel1 in Fission Yeast

Zhao, H., Tanaka, K., Nogochi, E., Nogochi, C., & Russell, P. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8395-8403.2003 · Cited by 63 · see citing works

Identification and validation of a prognostic four-genes signature for hepatocellular carcinoma: integrated ceRNA network analysis

Yan, Y., Lu, Y. J., Mao, K., Zhang, M., Liu, H., Zhou, Q., Lin, J., Zhang, J., Wang, J., & Xiao, Z. (2019) · Hepatology International · doi:10.1007/s12072-019-09962-3 · Cited by 62 · see citing works

Localization of checkpoint and repair proteins in eukaryotes

Lisby, M., & Rothstein, R. J. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.023 · Cited by 60 · see citing works

Chk1 is required to maintain Claspin stability

Chini, C. C. S., Wood, J., & Chen, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209447 · Cited by 62 · see citing works

Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase

Hustedt, N., Gasser, S. M., & Shimada, K. (2013) · Genes · doi:10.3390/genes4030388 · Cited by 57 · see citing works

Cdk Inhibition in Human Cells Compromises Chk1 Function and Activates a DNA Damage Response

Maude, S. L., & Enders, G. H. (2005) · Cancer Research · doi:10.1158/0008-5472.780.65.3 · Cited by 58 · see citing works

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV

Hollingworth, R., Skalka, G., Stewart, G. S., Hislop, A. D., Blackbourn, D. J., & Grand, R. J. A. (2015) · Viruses · doi:10.3390/v7062752 · Cited by 57 · see citing works

Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1

Cassidy, K. B., Bang, S., Kurokawa, M., & Gerber, S. A. (2019) · FEBS Journal · doi:10.1111/febs.15132 · Cited by 61 · see citing works

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresPreprint

Yoo, H. Y., Jeong, S., & Dunphy, W. G. (2006) · Genes & Development · doi:10.1101/gad.1398806 · Cited by 58 · see citing works

Replication Stress, Defective S-phase Checkpoint and Increased Death in Plk2-Deficient Human Cancer Cells

Matthew, E. M., Yen, T. J., Dicker, D. T., Dorsey, J. F., Yang, W., Navaraj, A., & El‐Deiry, W. S. (2007) · Cell Cycle · doi:10.4161/cc.6.20.5079 · Cited by 56 · see citing works

Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase

Lindsey‐Boltz, L. A., Serçin, Ö., Choi, J.-H., & Sancar, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064485 · Cited by 55 · see citing works

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase

McGarry, E., Gaboriau, D. C. A., Rainey, M. D., Restuccia, U., Bachi, A., & Santocanale, C. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2890 · Cited by 54 · see citing works

The human intra-S checkpoint response to UVC-induced DNA damage

Kaufmann, W. K. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp230 · Cited by 52 · see citing works

Kinome expression profiling to target new therapeutic avenues in multiple myeloma

de Boussac, H., Bruyer, A., Jourdan, M., Maes, A., Robert, N., Gourzonès, C., Vincent, L., Seckinger, A., Cartron, G., Hose, D., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.208306 · Cited by 48 · see citing works

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Yang, C.-C., Suzuki, M., Yamakawa, S., Uno, S., Ishii, A., Yamazaki, S., Fukatsu, R., Fujisawa, R., Sakimura, K., Tsurimoto, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms12135 · Cited by 50 · see citing works

Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy

Studach, L. L., Wang, W., Weber, G. J., Tang, J., Hullinger, R. L., Malbrue, R. A., Liu, X., & ANDRISANI, O. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093963 · Cited by 50 · see citing works

Differential Mode of Regulation of the Checkpoint Kinases CHK1 and CHK2 by Their Regulatory Domains

Ng, C.-P., Lee, H. C., Ho, C. W., Arooz, T., Siu, W. Y., Lau, A. W. S., & Poon, R. Y. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312215200 · Cited by 50 · see citing works

Roles of Human AND-1 in Chromosome Transactions in S Phase

Yoshizawa-Sugata, N., & Masai, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806711200 · Cited by 49 · see citing works

Altered Replication in Human Cells Promotes DMPK (CTG) n · (CAG) n Repeat Instability

Liu, G., Chen, X., Gao, Y., Lewis, T., Barthelemy, J., & Leffak, M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06727-11 · Cited by 47 · see citing works

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

Lin, Y., Shih, H.-Y., Shang, Z., Matsunaga, S., & Chen, B. P. C. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku116 · Cited by 48 · see citing works

Early Events in the DNA Damage Response

Ward, I. M., & Chen, J. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)63001-8 · Cited by 48 · see citing works

Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents

Liu, J.-S., Kuo, S.-R., & Melendy, T. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.018 · Cited by 47 · see citing works

Stalled replication forks: Making ends meet for recognition and stabilization

Masai, H., Tanaka, T., & Kohda, D. (2010) · BioEssays · doi:10.1002/bies.200900196 · Cited by 47 · see citing works

TWEAK Affects Keratinocyte G2/M Growth Arrest and Induces Apoptosis through the Translocation of the AIF Protein to the Nucleus

Alaoui, S. S., Dessirier, V., de Araujo, E., Alexaki, V. I., Pelekanou, V., Lkhider, M., Stathopoulos, E. N., Castanas, E., Bagot, M., Bensussan, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033609 · Cited by 47 · see citing works

Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome

Semple, J. I., Smits, V. A. J., Hernandez-Fernaud, J. R., Mamely, I., & Freire, R. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402134 · Cited by 45 · see citing works

Cleavage of Claspin by Caspase-7 during Apoptosis Inhibits the Chk1 Pathway

Clarke, C., Bennett, L. N., & Clarke, P. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506460200 · Cited by 46 · see citing works

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 45 · see citing works

Claspin, a regulator of Chk1 in DNA replication stress pathway

Chini, C. C. S., & Chen, J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.001 · Cited by 85 · see citing works

Claspin – checkpoint adaptor and DNA replication factor

Smits, V. A. J., Cabrera, E., Freire, R., & Gillespie, D. A. (2018) · FEBS Journal · doi:10.1111/febs.14594 · Cited by 97 · see citing works

Understanding the role of Claspin in DNA damage checkpoints

Sar, F. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/r8wc-5e17

Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function

Chini, C. C. S., & Chen, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604373200 · Cited by 78 · see citing works

Chk1 is required to maintain Claspin stability

Chini, C. C. S., Wood, J., & Chen, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209447 · Cited by 62 · see citing works