The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
Open accessAbstract
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells with a secondary structure-templated chemical library, looking for compounds that inhibit a β-catenin-responsive reporter. We identified ICG-001, a small molecule that down-regulates β-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
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Cites
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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
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The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
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MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
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Cited by
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt/β-catenin signaling and disease
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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519
Metadata
- Authors
- Emami, K. H., Nguyen, C., Ma, H., Kim, D. H., Jeong, K. W., Eguchi, M., Moon, R. T., Teo, J.-L., Oh, S. W., Kim, H. Y., Moon, S. H., Ha, J. R., & Kahn, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-08-16
- Volume
- 101
- Issue
- 34
- Pages
- 12682-12687
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2115001053
- Cited by
- 874
- References
- 43
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Emami, K. H., Nguyen, C., Ma, H., Kim, D. H., Jeong, K. W., Eguchi, M., Moon, R. T., Teo, J.-L., Oh, S. W., Kim, H. Y., Moon, S. H., Ha, J. R., & Kahn, M. (2004). A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0404875101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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