The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Promise and Perils of Wnt Signaling Through β-Catenin
Abstract
Wnt pathways are involved in the control of gene expression, cell behavior, cell adhesion, and cell polarity. In addition, they often operate in combination with other signaling pathways. The Wnt/β-catenin pathway is the best studied of the Wnt pathways and is highly conserved through evolution. In this pathway, Wnt signaling inhibits the degradation of β-catenin, which can regulate transcription of a number of genes. Some of the genes regulated are those associated with cancer and other diseases (for example, colorectal cancer and melanomas). As a result, components of the Wnt/β-catenin pathway are promising targets in the search for therapeutic agents. Information about Wnt pathways is available both in canonical terms and at the species level. In addition to the canonical Wnt/β-catenin pathway, information is now available for Drosophila , Caenorhabditis elegans , and Xenopus . The STKE Connections Maps for these pathways provide an important tool in accessing this large body of complex information.
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Comparative Genomics of the Eukaryotes
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Self-citationFrzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518
POP-1 controls axis formation during early gonadogenesis in C. elegans
Siegfried, K. R., & Kimble, J. (2002) · Development · doi:10.1242/dev.129.2.443 · Cited by 136
Cited by
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., & Brivanlou, A. H. (2004) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,109
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Self-citationMolecular Aspects of Thyroid Hormone Actions
Cheng, S.-Y., Leonard, J. L., & Davis, P. J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0007 · Cited by 1,384
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
Emami, K. H., Nguyen, C., Ma, H., Kim, D. H., Jeong, K. W., Eguchi, M., Moon, R. T., Teo, J.-L., Oh, S. W., Kim, H. Y., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404875101 · Cited by 874
Self-citationCdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835
Metadata
- Authors
- Moon, R. T., Bowerman, B., Boutros, M., & Perrimon, N.
- Venue
- Science
- Published
- 2002-05-31
- Volume
- 296
- Issue
- 5573
- Pages
- 1644-1646
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2166254889
- Cited by
- 969
- References
- 5
- FWCI
- 25.59
- Type
- journal article
- Language
- en
- Open access
- closed
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