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Molecular basis for catecholaminergic neuron diversity

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Grimm, Jan, Mueller, Anne, Hefti, Franz, Rosenthal, Arnon·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0405340101PMC PMC518849

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Abstract

Catecholaminergic neurons control diverse cognitive, motor, and endocrine functions and are associated with multiple psychiatric and neurodegenerative disorders. We present global gene-expression profiles that define the four major classes of dopaminergic (DA) and noradrenergic neurons in the brain. Hypothalamic DA neurons and noradrenergic neurons in the locus coeruleus display distinct group-specific signatures of transporters, channels, transcription, plasticity, axon-guidance, and survival factors. In contrast, the transcriptomes of midbrain DA neurons of the substantia nigra and the ventral tegmental area are closely related with <1% of differentially expressed genes. Transcripts implicated in neural plasticity and survival are enriched in ventral tegmental area neurons, consistent with their role in schizophrenia and addiction and their decreased vulnerability in Parkinson's disease. The molecular profiles presented provide a basis for understanding the common and population-specific properties of catecholaminergic neurons and will facilitate the development of selective drugs.

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Authors: Grimm, J., Mueller, A., Hefti, F., & Rosenthal, A.
Affiliations: Stanford Medicine (US)
ORCID: Mueller, Anne
Hefti, Franz
Rosenthal, Arnon
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2004-09-07
Volume: 101
Issue: 38
Pages: 13891-13896
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0405340101
PMC: PMC518849
OpenAlex: W2131058184
Cited by: 150
References: 55
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 15 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 14 · 2013: 8 · 2012: 7
FWCI: 2.93
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: catecholaminergic neurons, dopaminergic neurons, noradrenergic neurons, neuronal heterogeneity, gene expression profiling, locus coeruleus, substantia nigra, ventral tegmental area, midbrain dopaminergic neurons, neuroplasticity, axon guidance, schizophrenia, addiction, Parkinson's disease
MeSH terms: Animals, Catecholamines, Female, Gene Amplification, Hydrogen Peroxide, Neurons, RNA, Rats, Sprague-Dawley, In Situ Hybridization, Pyramidal Cells, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Rats

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Molecular basis for catecholaminergic neuron diversity

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