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Spatial memory, recognition memory, and the hippocampus
Open accessAbstract
There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30-50% total volume, and as lesion size increased from 50% to approximately 100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50-75% of total hippocampal volume and was impaired only after larger lesions that encompassed 75-100% of hippocampal volume. Last, ventral hippocampal lesions that encompassed approximately 50% of total hippocampal volume impaired spatial memory but did not affect object recognition memory. These findings show that the hippocampus is important for both spatial memory and recognition memory. However, spatial memory performance requires more hippocampal tissue than does recognition memory.
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“Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory (Ainge et al., 2006; Broadbent et al., 2010; Broadbent et al., 2004; Clark et al., 2000), whereas the majority of the studies employing hippocampal lesions in rats failed to report an influence in the NOP test (Albasser et al., 2012; Albasser et al., 2010; Barker and Warburton”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2004
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“Lesion extent of the hippocampus has been discussed, in that severe, but not partial, lesions influenced NOP memory (Broadbent et al., 2004).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2004
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Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Self-citationSquire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
Self-citationRecognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,624
From Conditioning to Conscious Recollection
Eichenbaum, H., & Cohen, N. J. (2004) · doi:10.1093/acprof:oso/9780195178043.001.0001 · Cited by 1,026
Moser, E., Moser, M. ‐., & Andersen, P. N. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03916.1993 · Cited by 953
Spatial learning with a minislab in the dorsal hippocampus.
Moser, M., Moser, E. I., Forrest, E., Andersen, P. N., & Morris, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9697 · Cited by 944
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740
Self-citationHippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714
Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
Brun, V. H., Otnæss, M. K., Molden, S., Steffenach, H.-A., Witter, M. P., Moser, M.-B., & Moser, E. I. (2002) · Science · doi:10.1126/science.1071089 · Cited by 606
Winters, B. D., Forwood, S., Cowell, R. A., Saksida, L. M., & Bussey, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1346-04.2004 · Cited by 588
Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region
Zola, S. M., Squire, L. R., Teng, E., Stefanacci, L., Buffalo, E. A., & Clark, R. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00451.2000 · Cited by 477
Self-citationRecognition memory and the human hippocampus.
Manns, J., Hopkins, R., Reed, J. M., Kitchener, E. G., & Squire, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01147-9 · Cited by 472
Self-citationMurray, E. A., & Mishkin, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06568.1998 · Cited by 439
Bannerman, D. M., Yee, B. K., Good, M. A., Heupel, M. J., Iversen, S. D., & Rawlins, J. N. P. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.6.1170 · Cited by 397
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356
Effects of Stress and Hippocampal NMDA Receptor Antagonism on Recognition Memory in RatsPreprint
Baker, K. B., & Kim, J. J. (2002) · Learning & Memory · doi:10.1101/lm.46102 · Cited by 300
Holdstock, J. S., Mayes, A. R., Roberts, N., Cezayirli, E., Isaac, C. L., O'REILLY, R. C., & Norman, K. (2002) · Hippocampus · doi:10.1002/hipo.10011 · Cited by 292
Pothuizen, H. H. J., Zhang, W., Jongen‐Rêlo, A. L., Feldon, J., & Yee, B. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03170.x · Cited by 274
Lee, I., & Kesner, R. P. (2004) · Hippocampus · doi:10.1002/hipo.10167 · Cited by 270
Nemanic, S., Alvarado, M. C., & Bachevalier, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3763-03.2004 · Cited by 225
Handelmann, G. E., & Olton, D. S. (1981) · Brain Research · doi:10.1016/0006-8993(81)90183-9 · Cited by 181
SUZUKI, W. A., & Eichenbaum, H. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06726.x · Cited by 177
Retrograde and anterograde object recognition in rats with hippocampal lesions
Gaskin, S., Tremblay, A., & Mumby, D. G. (2003) · Hippocampus · doi:10.1002/hipo.10154 · Cited by 160
Rats with lesions of the hippocampus are impaired on the delayed nonmatching‐to‐sample task†
Clark, R. E., West, A. N., Zola, S. M., & Squire, L. R. (2001) · Hippocampus · doi:10.1002/hipo.1035 · Cited by 135
Self-citationde Hoz, L., Knox, J., & Morris, R. (2003) · Hippocampus · doi:10.1002/hipo.10079 · Cited by 135
Steffenach, H.-A., Sloviter, R. S., Moser, E. I., & Moser, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042700999 · Cited by 133
Duva, C. A., Floresco, S., Wunderlich, G. R., Lao, T. L., Pinel, J. P. J., & Phillips, A. G. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.6.1184 · Cited by 111
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex
Prusky, G. T., Douglas, R. M., Nelson, L., Shabanpoor, A., & Sutherland, R. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308528101 · Cited by 108
Nadel, L., & Bohbot, V. D. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 92
Zola, S. M., & Squire, L. R. (2001) · Hippocampus · doi:10.1002/hipo.1027 · Cited by 90
Self-citationDifferential involvement of amygdala and hippocampus in responding to novel objects and contexts.
Moses, S. N., Sutherland, R., & McDonald, R. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00820-1 · Cited by 53
Effects of hippocampal lesions on patterned motor learning in the rat
Gould, T. J., Rowe, W. B., Heman, K. L., Mesches, M. H., Young, D. A., Rose, G. M., & Bickford, P. C. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00832-8 · Cited by 48
Guinard, D., Usson, Y., Guillermet, C., & Saxod, R. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980817)398:1 · Cited by 41
Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1
Episodic memory, semantic memory, and amnesia
Squire, L. R., & Zola, S. M. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:3
Research works printed but not linked: 4
- Fujimichi R. Naya Y. & Miyashita Y. in Cognitive Neurosciences III ed. Gazzaniga M. S. (MIT Press Cambridge MA) in press.
- 10.1037/0735-7044.111.6.1184 · DOI
- Bannerman, D. M., Yee, B. K., Good, M. A., Heupel, M. J., Iversen, S. D. & Rawlins, J. N. (1999) Behav. Neurosci. 11, 1170-1188.
- 10.1073/pnas.0308528101 · DOI
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Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580
Recognition memory and the medial temporal lobe: a new perspective
Squire, L. R., Wixted, J. T., & Clark, R. E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2154 · Cited by 1,059
Self-citationA novel pathway regulates memory and plasticity via SIRT1 and miR-134
Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.005 · Cited by 694
Metadata
- Authors
- Broadbent, N. J., Squire, L. R., & Clark, R. E.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Clark, Robert E.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-09-27
- Volume
- 101
- Issue
- 40
- Pages
- 14515-14520
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC521976
- OpenAlex
- W2038813826
- Cited by
- 985
- References
- 37
- Citations by year
- 2026: 25 · 2025: 26 · 2024: 35 · 2023: 40 · 2022: 59 · 2021: 51 · 2020: 55 · 2019: 53 · 2018: 56 · 2017: 57 · 2016: 51 · 2015: 51 · 2014: 52 · 2013: 48 · 2012: 63
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- U.S. Department of Veterans Affairs
- James S. McDonnell Foundation
- National Alliance for Research on Schizophrenia and Depression
- National Institute on Aging (P50AG005131, P50-AG05131)
- National Institute of Mental Health (P50 AG05131, AG05131)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Keywords
- spatial memory, recognition memory, hippocampus, hippocampal lesions, lesion size, dorsal hippocampus, ventral hippocampus, object recognition, rats
- MeSH terms
- Animals, Hippocampus, Male, Memory, Spatial Behavior, Rats, Long-Evans, Recognition, Psychology, Rats
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