The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Epigenetic differences arise during the lifetime of monozygotic twins
Open accessAbstract
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“genetics alone do not account for most of the risk of major depression.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [17]
Experimental — accuracy not yet measuredIn the citing paper
“Environmental conditions clearly influence epigenetic profiles in human immune cells [37], and some studies have begun to link immune cell DNA methylation profiles to specific social environmental conditions such as low social status [7] and early life stress exposure [38]–[41].”
From Human Social Genomics (2014) · cites this paper as [37]
In the citing paper
“Identical twin studies have shown a high discordance rate for MDD of 50%, indicating the importance of non-genetic factors.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [4]
In the citing paper
“Studies with monozygotic twins suggest the accumulation of epigenetic changes as twins age (e.g., demethylation of 5-methylcytosines in DNA), thus affecting the transcriptome (Fraga et al., 2005).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fraga et al., 2005
In the citing paper
“For example, identical twins diverge over the life course in patterns of CpG methylation of their DNA reflecting the influence of “non-shared” experiences.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926
Self-citationAllen, R. C., Zoghbi, H. Y., Moseley, A., Rosenblatt, H. M., & Belmont, J. W. (1992) · PubMed · Cited by 1,683
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Nuclear Cloning and Epigenetic Reprogramming of the Genome
Rideout, W. M., Eggan, K. C., & Jaenisch, R. (2001) · Science · doi:10.1126/science.1063206 · Cited by 756
A Twin Study of Genetic Relationships Between Psychotic Symptoms
Cardno, A. G., Rijsdijk, F. V., Sham, P. C., Murray, R. M., & McGuffin, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.539 · Cited by 460
An integrated epigenetic and genetic approach to common human disease
BJORNSSON, H. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.009 · Cited by 448
Phenotypic differences in genetically identical organisms: the epigenetic perspective.
Wong, A., Gottesman, I., & Petronis, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi116 · Cited by 438
Weksberg, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1317 · Cited by 329
Epigenetics and Assisted Reproductive Technology: A Call for Investigation
Niemitz, E. L., & Feinberg, A. P. (2004) · The American Journal of Human Genetics · doi:10.1086/382897 · Cited by 328
Research works printed but not linked: 4
- Hall J. G. & Lopez-Rangel E. (1966) in Twins and Twinning eds. Emery A. E. H. & Rimoin D. L. (Churchill Livingstone New York) pp. 395-404.
- Becker, A., Busjahn, A., Faulhaber, H. D., Bahring, S., Robertson, J., Schuster H. & Luft, F. C. (1997) J. Reprod. Med. 42, 260-266.9172114
- Allen, R. C., Zoghbi, H. Y., Moseley, A. B., Rosenblatt, H. M. & Belmont, J. W. (1992) Am. J. Hum. Genet. 51, 1229-1239.1281384
- Cooney, C. A. (1993) Growth. Dev. Aging 57, 261-273.8300279
Cited by
Sorted by citations
Items 601–700 of 1,011
Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review
Zakari, S., Kaze, N. N., Olagunju, G. V., Nnaji, P. C., Ogunniyi, O. B., Tebamifor, M. E., Israel, E. N., Atawodi, S. E.-O., & Ogunlana, O. O. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1405267 · Cited by 104
Global DNA methylation in old subjects is correlated with frailty
Bellizzi, D., D’Aquila, P., Montesanto, A., Corsonello, A., Mari, V., Mazzei, B., Lattanzio, F., & Passarino, G. (2011) · AGE · doi:10.1007/s11357-011-9216-6 · Cited by 104
Brena, R. M., Huang, T. H. ‐., & Plass, C. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0034-0 · Cited by 104
Self-citationEpigenetics of major psychosis: progress, problems and perspectives
Labrie, V., Pai, S., & Petronis, A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.04.002 · Cited by 103
Biological information systems: Evolution as cognition-based information management
Miller, W. B. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.11.005 · Cited by 103
Abnormal Epigenetic Regulation of Immune System during Aging
Jasiulionis, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00197 · Cited by 103
The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
Gensous, N., Franceschi, C., Santoro, A., Milazzo, M., Garagnani, P., & Bacalini, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20082022 · Cited by 103
Haas, C. S., Creighton, C. J., Pi, X., Maine, I., Koch, A. E., Haines, G. K., Ling, S., Chinnaiyan, A. M., & Holoshitz, J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21953 · Cited by 102
Differential DNA methylation of the D4Z4 repeat in patients with FSHD and asymptomatic carriers
Gaillard, M.-C., Roche, S., Dion, C., Tasmadjian, A., Bouget, G., Salort‐Campana, E., Vovan, C., Chaix, C., Broucqsault, N., Morere, J., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000708 · Cited by 102
Tajuddin, S. M., Hernandez, D. G., Chen, B. H., Hooten, N. N., Mode, N. A., Nalls, M. A., Singleton, A., Ejiogu, N., Chitrala, K. N., Zonderman, A. B., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0722-1 · Cited by 102
The exposome – a new approach for risk assessment
Sillé, F. C. M. (2020) · ALTEX · doi:10.14573/altex.2001051 · Cited by 102
Genetics and developmental pathology of twinning
Weber, M. A., & Sebire, N. J. (2010) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2010.06.002 · Cited by 102
Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequencesPreprint
Schilling, E., Chartouni, C. E., & Rehli, M. (2009) · Genome Research · doi:10.1101/gr.095562.109 · Cited by 102
Increased DNA methylation in the suicide brain
Haghighi, F., Xin, Y., Chanrion, B., O'Donnell, A. H., Ge, Y., Dwork, A. J., Arango, V., & Mann, J. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/jmann · Cited by 101
The promise and failures of epigenetic therapies for cancer treatment
Bojang, P., & Ramos, K. S. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.05.009 · Cited by 101
The value of twins in epigenetic epidemiology
Bell, J. T., & Saffery, R. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr179 · Cited by 101
Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
Griñán‐Ferré, C., Sarroca, S., Ivanova, A., Puigoriol‐Illamola, D., Aguado, F., Camins, A., Sanfeliu, C., & Pallàs, M. (2016) · Aging · doi:10.18632/aging.100906 · Cited by 101
Measuring Animal Age with DNA Methylation: From Humans to Wild Animals
Paoli‐Iseppi, R. D., Deagle, B. E., McMahon, C. R., Hindell, M. A., Dickinson, J. L., & Jarman, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00106 · Cited by 101
Vaccination as a preventative measure contributing to immune fitness
Laupèze, B., Giudice, G. D., Doherty, M. T., & der Most, R. G. V. (2021) · npj Vaccines · doi:10.1038/s41541-021-00354-z · Cited by 101
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases
López, V., Fernández, A. F., & Fraga, M. F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.002 · Cited by 101
Self-citationAging epigenetics: Causes and consequences
Huidobro, C., Fernández, A. F., & Fraga, M. F. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.006 · Cited by 100
Self-citationPresent and future of anti-ageing epigenetic diets
Bacalini, M. G., Friso, S., Olivieri, F., Pirazzini, C., Giuliani, C., Capri, M., Santoro, A., Franceschi, C., & Garagnani, P. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.006 · Cited by 100
Cowley, A. W., Nadeau, J. H., Baccarelli, A., Berecek, K. H., Fornage, M., Gibbons, G. H., Harrison, D. G., Liang, M., Nathanielsz, P. W., O’Connor, D. T., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.190116 · Cited by 100
A systematic review on different models of inducing obesity in animals: Advantages and limitations
Suleiman, J. B., Mohamed, M., & Bakar, A. B. A. (2020) · Journal of Advanced Veterinary and Animal Research · doi:10.5455/javar.2020.g399 · Cited by 100
Epigenetics in depression and gut-brain axis: A molecular crosstalk
Begum, N., Mandhare, A., Tryphena, K. P., Srivastava, S., Shaikh, M. F., Singh, S. B., & Khatri, D. K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048333 · Cited by 102
Epigenetics of the vascular endothelium
Yan, M. S.-C., Matouk, C. C., & Marsden, P. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00131.2010 · Cited by 100
Epigenetics and depressive disorders: a review of current progress and future directions
Januar, V., Saffery, R., & Ryan, J. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu273 · Cited by 99
DNA methylation-based age prediction from various tissues and body fluids
Jung, S.-E., Shin, K., & Lee, H. Y. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.11.175 · Cited by 99
Primers on nutrigenetics and nutri(epi)genomics: Origins and development of precision nutrition
Bordoni, L., & Gabbianelli, R. (2019) · Biochimie · doi:10.1016/j.biochi.2019.03.006 · Cited by 99
Vogt, G. (2008) · Journal of Zoology · doi:10.1111/j.1469-7998.2008.00473.x · Cited by 99
Epigenetics and environmental exposures
Stein, R. A. (2011) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2010.130690 · Cited by 99
The Neurobiology of Intervention and Prevention in Early Adversity
Fisher, P. A., Beauchamp, K. G., Roos, L. E., Noll, L. K., Flannery, J., & Delker, B. C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032814-112855 · Cited by 98
Lehn, H., Derks, E. M., Hudziak, J. J., Heutink, P., van BEIJSTERVELDT, T. C. E. M., & Boomsma, D. I. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242244.00174.d9 · Cited by 98
Methylation matters in child development: toward developmental behavioral epigenetics
van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., & Ebstein, R. P. (2011) · Child Development Perspectives · doi:10.1111/j.1750-8606.2011.00202.x · Cited by 97
Asthma Discordance in Twins Is Linked to Epigenetic Modifications of T Cells
Runyon, R. S., Cachola, L. M., Rajeshuni, N., Hunter, T., Garcia, M. A., Ahn, R., Lurmann, F. W., Krasnow, R. E., Jack, L. M., Miller, R. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048796 · Cited by 97
Cecil, C. A. M., Barker, E. D., Jaffee, S. R., & Viding, E. M. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.107581 · Cited by 97
miRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer
Mathe, A., Scott, R. J., & Avery‐Kiejda, K. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226090 · Cited by 97
Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets
Javaid, N., & Choi, S. (2017) · Genes · doi:10.3390/genes8080196 · Cited by 97
Decoding the genetic and epigenetic basis of asthma
Stikker, B., Hendriks, R. W., & Stadhouders, R. (2023) · Allergy · doi:10.1111/all.15666 · Cited by 98
Epigenetics and the plasticity of differentiation in normal and cancer stem cells
Lotem, J., & Sachs, L. (2006) · Oncogene · doi:10.1038/sj.onc.1209816 · Cited by 97
Morahan, J. M., Yu, B., Trent, R. J., & Pamphlett, R. (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802635397 · Cited by 98
Genes and Environment: How Will Our Concepts on the Pathophysiology of IBD Develop in the Future?
Kaser, A., Zeißig, S., & Blumberg, R. S. (2010) · Digestive Diseases · doi:10.1159/000320393 · Cited by 97
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities
Ng, J. W. Y., Barrett, L. M., Wong, A., Kuh, D. J., Smith, G. D., & Relton, C. L. (2012) · Genome biology · doi:10.1186/gb-2012-13-6-246 · Cited by 97
Nicoletti, C. F., Nonino, C. B., de Oliveira, B. A. P., Pinhel, M. A. D. S., Mansego, M. L., Milagro, F. I., Zulet, M. Á., & Martínez, J. A. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1802-8 · Cited by 97
GENETIC TIES: ARE THEY MORALLY BINDING?
Fuscaldo, G. (2006) · Bioethics · doi:10.1111/j.1467-8519.2006.00478.x · Cited by 96
New targeted approaches for epigenetic age predictions
Han, Y., Franzen, J., Stiehl, T., Gobs, M., Kuo, C., Nikolić, M., Hapala, J., Koop, B. E., Strathmann, K., Ritz‐Timme, S., et al. (2020) · BMC Biology · doi:10.1186/s12915-020-00807-2 · Cited by 96
From GWAS to biology: lessons from FTO
Tung, Y. L., & Yeo, G. S. H. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05903.x · Cited by 95
Zhang, F. F., Santella, R. M., Wolff, M. S., Deyssenroth, M. A., Markowitz, S. B., & Morabia, A. (2012) · Epigenetics · doi:10.4161/epi.20236 · Cited by 95
Coolen, M. W., Statham, A. L., Qu, W., Campbell, M. J., Henders, A. K., Montgomery, G. W., Martin, N. G., & Clark, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025590 · Cited by 95
Aging is associated with highly defined epigenetic changes in the human epidermis
Raddatz, G., Hagemann, S., Aran, D., Söhle, J., Kulkarni, P. P., Kaderali, L., Hellman, A., Winnefeld, M., & Lyko, F. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-36 · Cited by 95
A DNA methylation map of human cancer at single base-pair resolution
Vidal, E., Sayols, S., Morán, S., Guillaumet-Adkins, A., Schroeder, M. P., Royo, R., Orozco, M., Gut, I. G., Gut, I. G., López-Bigas, N., et al. (2017) · Oncogene · doi:10.1038/onc.2017.176 · Cited by 95
Self-citationHuang, S. K., Scruggs, A. M., McEachin, R. C., White, E. S., & Peters-Golden, M. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107055 · Cited by 95
Nutrigenomics and Personalized Nutrition: Science and Concept
Kussmann, M., & Fay, L. B. (2008) · Personalized Medicine · doi:10.2217/17410541.5.5.447 · Cited by 95
The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases
Olaharski, A. J., Rine, J., Marshall, B. L., Babiarz, J., Zhang, L., Verdin, E. M., & Smith, M. T. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010077 · Cited by 95
Genetic variants in epigenetic genes and breast cancer risk
Cebrián, A., Pharoah, P. D. P., Ahmed, S., Ropero, S., Fraga, M. F., Smith, P. L., Conroy, D. M., Luben, R., Perkins, B., Easton, D. F., et al. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi375 · Cited by 95
Self-citationGenetic and epigenetic predictors of responsiveness to treatment in RA
Plant, D., Wilson, A. G., & Barton, A. C. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.16 · Cited by 94
Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity
Almén, M. S., Nilsson, E., Jacobsson, J. A., Kalniņa, I., Kloviņš, J., Fredriksson, R., & Schiöth, H. B. (2014) · Gene · doi:10.1016/j.gene.2014.07.009 · Cited by 94
Principles and Challenges of Applying Epigenetic Epidemiology to Psychology
Jones, M. J., Moore, S. R., & Kobor, M. S. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033653 · Cited by 94
Román, G. C., Páez, O. M., & Bernal, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020319 · Cited by 94
The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects
Cupaioli, F. A., Zucca, F. A., Caporale, C., Lesch, K., Passamonti, L., & Zecca, L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110059 · Cited by 94
Church, D., Stapleton, P., Vasudevan, A., & O’Keefe, T. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.951451 · Cited by 94
Culberson, J. W., Kopel, J. J., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102001 · Cited by 95
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Nishioka, M., Bundo, M., Kasai, K., & Iwamoto, K. (2012) · Genome Medicine · doi:10.1186/gm397 · Cited by 94
Aging as an Epigenetic Phenomenon
Ashapkin, V. V., Kutueva, L. I., & Vanyushin, B. F. (2017) · Current Genomics · doi:10.2174/1389202918666170412112130 · Cited by 94
Prenatal Nutrition, Epigenetics and Schizophrenia Risk: Can We Test Causal Effects?
Kirkbride, J. B., Susser, E., Kundaković, M., Kresovich, J. K., Smith, G. D., & Relton, C. L. (2012) · Epigenomics · doi:10.2217/epi.12.20 · Cited by 93
Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 95
Gene expression variability: the other dimension in transcriptome analysis
de Jong, T. V., Moshkin, Y. M., & Guryev, V. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00128.2018 · Cited by 93
Epigenomic heterogeneity as a source of tumour evolution
Laisné, M., Lupien, M., & Vallot, C. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00757-9 · Cited by 93
One-carbon metabolism in psychiatric illness
Sugden, C. (2006) · Nutrition Research Reviews · doi:10.1079/nrr2006119 · Cited by 93
Epigenetic mechanisms and the relationship to childhood asthma
Kabesch, M., Michel, S., & Tost, J. (2010) · European Respiratory Journal · doi:10.1183/09031936.00019310 · Cited by 93
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
Ecker, S., Pancaldi, V., Valencia, A., Beck, S., & Paul, D. S. (2017) · BioEssays · doi:10.1002/bies.201700148 · Cited by 93
Recreational and household physical activity at different time points and DNA global methylation
White, A. J., Sandler, D. P., Bolick, S. C. E., Xu, Z., Taylor, J. A., & DeRoo, L. A. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.02.013 · Cited by 92
Gavin, D. P., Kartan, S., Chase, K. A., Jayaraman, S., & Sharma, R. P. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.12.006 · Cited by 92
The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease
Bayoumi, A., Grønbæk, H., George, J., & Eslam, M. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.03.003 · Cited by 92
Sellami, M., Bragazzi, N. L., Prince, M. S., Denham, J., & Elrayess, M. A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.652497 · Cited by 91
Lashley, T., Gami‐Patel, P., Valizadeh, N., Li, A., Révész, T., & Balázs, R. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12183 · Cited by 92
Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure
Kim, H. J., Choi, M. G., Park, M. K., & Seo, Y. R. (2017) · Journal of Cancer Prevention · doi:10.15430/jcp.2017.22.1.6 · Cited by 92
Gender balance in patients with systemic lupus erythematosus
Margery-Muir, A. A., Bundell, C. S., Nelson, D. J., Groth, D., & Wetherall, J. D. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.01.007 · Cited by 91
He, Z., Zhang, R., Jiang, F., Zhang, H., Zhao, A., Xu, B., Jin, L., Wang, T., Jia, W. P., Jia, W., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0545-5 · Cited by 91
Prognostic and Predictive Epigenetic Biomarkers in Oncology
Kaminska, K. H., Nalejska, E., Kubiak, M., Wojtysiak, J., Żołna, Ł., Kowalewski, J., & Lewandowska, M. A. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0371-7 · Cited by 91
The role of environmental exposures and the epigenome in health and disease
Perera, B. P. U., Faulk, C. D., Svoboda, L. K., Goodrich, J. M., & Dolinoy, D. C. (2019) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22311 · Cited by 91
Application of Nanoparticles in Cancer Treatment: A Concise Review
Sell, M., Lopes, A. R., Escudeiro, M., Esteves, B., Monteiro, A. R., Trindade, T., & Cruz‐Lopes, L. (2023) · Nanomaterials · doi:10.3390/nano13212887 · Cited by 91
In Utero Life and Epigenetic Predisposition for Disease
Thornburg, K. L. R., Shannon, J., Thuillier, P., & Turker, M. S. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380864-6.00003-1 · Cited by 91
Hormesis and epigenetics: Is there a link?
Vaiserman, A. M. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.004 · Cited by 91
Age-related difference of site-specific histone modifications in rat liver
Kawakami, K., Nakamura, A., Ishigami, A., Goto, S., & Takahashi, R. (2008) · Biogerontology · doi:10.1007/s10522-008-9176-0 · Cited by 91
Matosin, N., Cruceanu, C., & Binder, E. B. (2017) · Chronic Stress · doi:10.1177/2470547017710764 · Cited by 92
The epigenetic alterations of endogenous retroelements in aging
Cardelli, M. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.02.002 · Cited by 91
Role of Income and Family Influence on Child Outcomes
Heckman, J. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1425.031 · Cited by 90
Epigenetic Variability in the Genetically Uniform Forest Tree Species Pinus pinea L
Sáez-Laguna, E., Guevara, M. Á., Díaz, L.-M., Sánchez‐Gómez, D., Collada, C., Aranda, I., & Cervera, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103145 · Cited by 90
Poulin, R., & Frédéric Thomas, A. (2007) · Oikos · doi:10.1111/j.2007.0030-1299.16435.x · Cited by 90
Methylomic changes during conversion to psychosis
the ICAAR team, Kébir, O., Chaumette, B., Rivollier, F., Miozzo, F., Perreault, L. L., Barhdadi, A., Provost, S., Plaze, M., Bourgin, J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.53 · Cited by 90
Auletta, G. (2011) · doi:10.1093/acprof:oso/9780199608485.001.0001 · Cited by 91
The Role of DNA Methylation in the Development and Progression of Lung Adenocarcinoma
Kerr, K. M., Galler, J. S., Hagen, J. A., Laird, P. W., & Laird‐Offringa, I. A. (2007) · Disease Markers · doi:10.1155/2007/985474 · Cited by 90
DNA methylation studies using twins: what are they telling us?
Bell, J. T., & Spector, T. D. (2012) · Genome Biology · doi:10.1186/gb-2012-13-10-172 · Cited by 89
Self-citationAnalyzing the cancer methylome through targeted bisulfite sequencing
Lee, E.-J., Luo, J., Wilson, J. M., & Shi, H. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.10.040 · Cited by 89
Salivary DNA Methylation Profiling: Aspects to Consider for Biomarker Identification
Langie, S. A. S., Moisse, M., Declerck, K., Koppen, G., Godderis, L., Berghe, W. V., Drury, S. S., & Boever, P. D. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12721 · Cited by 89
Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery
Lolodi, O., Wang, Y., Wright, W. C., & Chen, T. (2017) · Current Drug Metabolism · doi:10.2174/1389200218666170531112038 · Cited by 89
Rasmi, Y., Shokati, A., Hassan, A., Aziz, S. G., Bastani, S., Jalali, L., Moradi, F., & Alipour, S. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.12.002 · Cited by 89
Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts
Nielsen, D. A., Hamon, S., Yuferov, V. P., Jackson, C., Ho, A., Ott, J., & Kreek, M. J. (2010) · Human Genetics · doi:10.1007/s00439-010-0807-6 · Cited by 89
Epigenetics of Cancer Progression
Vucic, E. A., Brown, C. J., & Lam, W. L. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.2.215 · Cited by 89
Metadata
- Authors
- Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., Boix-Chornet, M., Sanchez-Aguilera, A., Ling, C., Carlsson, E., Poulsen, P., Vaag, A., Stephan, Z., Spector, T. D., Wu, Y.-Z., Plass, C., & Esteller, M.
- Affiliations
- Universitat de València (ES)
- Epigenetics, Cytogenetics, and Genetic Laboratories, Spanish National Cancer Centre (CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain; Department of Behavioral Science, University of Valencia, 46010 Valencia, Spain; Molecular Genetics Laboratory, Genetics Department, Son Dureta Hospital, 07014 Palma de Mallorca, Spain; Department of Clinical Sciences, University Hospital Malmö, Lund University, S-205 02 Malmö, Sweden; Steno Diabetes Center, 2820 Gentofte, Denmark; Twin Research and Genetic...
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-07-11
- Volume
- 102
- Issue
- 30
- Pages
- 10604-10609
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1174919
- OpenAlex
- W2134555277
- Cited by
- 3,602
- References
- 20
- Citations by year
- 2026: 65 · 2025: 87 · 2024: 113 · 2023: 115 · 2022: 143 · 2021: 119 · 2020: 147 · 2019: 161 · 2018: 185 · 2017: 173 · 2016: 191 · 2015: 225 · 2014: 223 · 2013: 242 · 2012: 293
- FWCI
- 51.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Hispana (submittedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- monozygotic twins, epigenetic variation, DNA methylation, histone acetylation, 5-methylcytosine, phenotypic discordance, gene expression, aging
- MeSH terms
- Acetylation, Adult, Analysis of Variance, Female, Histones, Humans, Male, Phenotype, Surveys and Questionnaires, Spain, Twins, Monozygotic, Restriction Mapping, Sequence Analysis, DNA, Gene Expression Regulation, Developmental, Electrophoresis, Capillary, DNA Methylation, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Nucleic Acid Amplification Techniques, Epigenesis, Genetic, 5-Methylcytosine, X Chromosome Inactivation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
