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Epigenetic differences arise during the lifetime of monozygotic twins
Open accessAbstract
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.
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In the citing paper
“genetics alone do not account for most of the risk of major depression.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [17]
Experimental — accuracy not yet measuredIn the citing paper
“Environmental conditions clearly influence epigenetic profiles in human immune cells [37], and some studies have begun to link immune cell DNA methylation profiles to specific social environmental conditions such as low social status [7] and early life stress exposure [38]–[41].”
From Human Social Genomics (2014) · cites this paper as [37]
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“Identical twin studies have shown a high discordance rate for MDD of 50%, indicating the importance of non-genetic factors.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [4]
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“Studies with monozygotic twins suggest the accumulation of epigenetic changes as twins age (e.g., demethylation of 5-methylcytosines in DNA), thus affecting the transcriptome (Fraga et al., 2005).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fraga et al., 2005
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“For example, identical twins diverge over the life course in patterns of CpG methylation of their DNA reflecting the influence of “non-shared” experiences.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [76]
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Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926
Self-citationAllen, R. C., Zoghbi, H. Y., Moseley, A., Rosenblatt, H. M., & Belmont, J. W. (1992) · PubMed · Cited by 1,683
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Nuclear Cloning and Epigenetic Reprogramming of the Genome
Rideout, W. M., Eggan, K. C., & Jaenisch, R. (2001) · Science · doi:10.1126/science.1063206 · Cited by 756
A Twin Study of Genetic Relationships Between Psychotic Symptoms
Cardno, A. G., Rijsdijk, F. V., Sham, P. C., Murray, R. M., & McGuffin, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.539 · Cited by 460
An integrated epigenetic and genetic approach to common human disease
BJORNSSON, H. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.009 · Cited by 448
Phenotypic differences in genetically identical organisms: the epigenetic perspective.
Wong, A., Gottesman, I., & Petronis, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi116 · Cited by 438
Weksberg, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1317 · Cited by 329
Epigenetics and Assisted Reproductive Technology: A Call for Investigation
Niemitz, E. L., & Feinberg, A. P. (2004) · The American Journal of Human Genetics · doi:10.1086/382897 · Cited by 328
Flagged first, then by citations
1 of the 20 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Hall J. G. & Lopez-Rangel E. (1966) in Twins and Twinning eds. Emery A. E. H. & Rimoin D. L. (Churchill Livingstone New York) pp. 395-404.
- Becker, A., Busjahn, A., Faulhaber, H. D., Bahring, S., Robertson, J., Schuster H. & Luft, F. C. (1997) J. Reprod. Med. 42, 260-266.9172114
- Allen, R. C., Zoghbi, H. Y., Moseley, A. B., Rosenblatt, H. M. & Belmont, J. W. (1992) Am. J. Hum. Genet. 51, 1229-1239.1281384
- Cooney, C. A. (1993) Growth. Dev. Aging 57, 261-273.8300279
Cited by
Sorted by citations
Items 101–200 of 1,011
Pietiläinen, K. H., Sysi‐Aho, M., Rissanen, A., Seppänen‐Laakso, T., Yki‐Järvinen, H., Kaprio, J. A., & Orešič, M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000218 · Cited by 418
Cole, S. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004601 · Cited by 415
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Genetic and environmental influences interact with age and sex in shaping the human methylome
van Dongen, J., Nivard, M. G., Willemsen, G. A. H. M., Hottenga, J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms11115 · Cited by 411
Genomic patterns of DNA methylation: targets and function of an epigenetic mark
Weber, M., & Schübeler, D. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.011 · Cited by 410
DNA methylation contributes to natural human variation
Heyn, H., Moran, S., Hernando-Herraez, I., Sayols, S., Gomez, A., Sandoval, J., Monk, D., Hata, K., Marques-Bonet, T., Wang, L., et al. (2013) · Genome Research · doi:10.1101/gr.154187.112 · Cited by 408
Self-citationPuzzles, promises and a cure for ageing
Vijg, J., & Campisi, J. (2008) · Nature · doi:10.1038/nature07216 · Cited by 407
Nilsson, E., Jansson, P. A., Perfilyev, A., Volkov, P., Pedersen, M., Svensson, M. K. E., Poulsen, P., Ribel‐Madsen, R., Pedersen, N. L., Almgren, P., et al. (2014) · Diabetes · doi:10.2337/db13-1459 · Cited by 407
Self-citationEpigenetic mechanisms of chronic pain
Descalzi, G., Ikegami, D., Ushijima, T., Nestler, E. J., Zachariou, V., & Narita, M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.02.001 · Cited by 402
Zhang, F. F., Cardarelli, R., Carroll, J. F., Fulda, K. G., Kaur, M., González, K., Vishwanatha, J. K., Santella, R. M., & Morabia, A. (2011) · Epigenetics · doi:10.4161/epi.6.5.15335 · Cited by 402
Rice, F. J., Harold, G. T., Boivin, J., van den Bree, M. B. M., Hay, D. F., & Thapar, A. (2009) · Psychological Medicine · doi:10.1017/s0033291709005911 · Cited by 402
Comparative isoschizomer profiling of cytosine methylation: The HELP assayPreprint
Khulan, B., Thompson, R. F., Ye, K. Q., Fazzari, M. J., Suzuki, M., Stasiek, E., Figueroa, M. E., Glass, J. L., Chen, Q., Montagna, C., et al. (2006) · Genome Research · doi:10.1101/gr.5273806 · Cited by 400
Environmental-induced oxidative stress in neurodegenerative disorders and aging
Migliore, L., & Coppedè, F. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.013 · Cited by 397
Systems medicine: the future of medical genomics and healthcare
Auffray, C., Zhu, C. H., & Hood, L. (2009) · Genome Medicine · doi:10.1186/gm2 · Cited by 397
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
Parimon, T., Yao, C., Stripp, B. R., Noble, P. W., & Chen, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072269 · Cited by 397
The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease
Johnson, A. A., Akman, K., Calimport, S., Wuttke, D., Stolzing, A., & de Magalhães, J. P. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1324 · Cited by 399
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Roberts, B. W., & Jackson, J. J. (2008) · Journal of Personality · doi:10.1111/j.1467-6494.2008.00530.x · Cited by 392
Stolk, R. P., Rosmalen, J. G. M., Postma, D. S., de Boer, R. A., Navis, G., Slaets, J. P. J., Ormel, J., & Wolffenbuttel, B. H. R. (2008) · European Journal of Epidemiology · doi:10.1007/s10654-007-9204-4 · Cited by 391
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Alisch, R. S., Barwick, B. G., Chopra, P., Myrick, L. K., Satten, G. A., Conneely, K. N., & Warren, S. T. (2012) · Genome Research · doi:10.1101/gr.125187.111 · Cited by 388
Cigarette smoking and DNA methylation
Lee, K. W. K., & Pausová, Z. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00132 · Cited by 384
The continuing value of twin studies in the omics era
van Dongen, J., Slagboom, P. E., Draisma, H. H. M., Martin, N. G., & Boomsma, D. I. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3243 · Cited by 384
Non‐genomic transgenerational inheritance of disease risk
Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · BioEssays · doi:10.1002/bies.20522 · Cited by 384
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Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381
The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls
Boks, M. P., Derks, E. M., Weisenberger, D. J., Strengman, E., Janson, E., Sommer, I. E., Kahn, R. S., & Ophoff, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006767 · Cited by 378
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors
Herceg, Z. (2007) · Mutagenesis · doi:10.1093/mutage/gel068 · Cited by 378
Epigenetics and Human DiseasePreprint
Zoghbi, H. Y., & Beaudet, A. L. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019497 · Cited by 373
Fransquet, P. D., Wrigglesworth, J., Woods, R. L., Ernst, M. E., & Ryan, J. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0656-7 · Cited by 369
Early Life Nutrition, Epigenetics and Programming of Later Life Disease
Vickers, M. (2014) · Nutrients · doi:10.3390/nu6062165 · Cited by 366
DNA methylation signatures in development and aging of the human prefrontal cortex
Numata, S., Ye, T., Hyde, T. M., Guitart-Navarro, X., Tao, R., Wininger, M., Colantuoni, C., Weinberger, D. R., Kleinman, J. E., & Lipska, B. K. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.020 · Cited by 364
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Teschendorff, A. E., Menon, U., Gentry‐Maharaj, A., Ramus, S. J., Gayther, S. A., Apostolidou, S., Jones, A., Lechner, M., Beck, S., Jacobs, I. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008274 · Cited by 364
Day, K. R., Waite, L. L., Thalacker‐Mercer, A. E., West, A. B., Bamman, M. M., Brooks, J. D., Myers, R., & Absher, D. (2013) · Genome biology · doi:10.1186/gb-2013-14-9-r102 · Cited by 363
A twin approach to unraveling epigenetics
Bell, J. T., & Spector, T. D. (2011) · Trends in Genetics · doi:10.1016/j.tig.2010.12.005 · Cited by 353
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Barth, T. K., & Imhof, A. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.006 · Cited by 349
Nagarajan, R., Hogart, A., Gwye, Y., Martin, M. R., & LaSalle, J. M. (2006) · Epigenetics · doi:10.4161/epi.1.4.3514 · Cited by 347
Rakyan, V. K., Beyan, H., Down, T. A., Hawa, M. I., Maslau, S., Aden, D., Daunay, A., Busato, F., Mein, C. A., Manfras, B. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002300 · Cited by 347
Diet induced epigenetic changes and their implications for health
McKay, J. A., & Mathers, J. C. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02278.x · Cited by 347
The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humans
Miller, J. L., & Grant, P. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4525-4_13 · Cited by 348
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de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345
Angers, B., Castonguay, E., & Massicotte, R. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2010.04580.x · Cited by 344
Rodríguez, J., Frigola, J., Vendrell, E., Risques, R., Fraga, M. F., Morales, C., Moreno, V. R., Esteller, M., Capellá, G., Ribas, M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0293 · Cited by 342
Self-citationPersonalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index
Feinberg, A. P., Irizarry, R. A., Fradin, D., Aryee, M. J., Murakami, P. N., Aspelund, T., Eiríksdóttir, G., Harris, T. B., Launer, L. J., Gudnason, V. G., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001262 · Cited by 341
Molecular mechanisms of epistasis within and between genes
Lehner, B. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.05.007 · Cited by 336
Use of Epigenetic Drugs in Disease: An Overview
Heerboth, S. A., LAPINSKA, K., Snyder, N., Leary, M., Rollinson, S., & Sarkar, S. (2014) · Genetics & Epigenetics · doi:10.4137/geg.s12270 · Cited by 333
A longitudinal study of epigenetic variation in twins
Wong, C. C. Y., Caspi, A., Williams, B. S., Craig, I., Houts, R., Ambler, A. P., Moffitt, T. E., & Mill, J. S. (2010) · Epigenetics · doi:10.4161/epi.5.6.12226 · Cited by 332
Non-coding RNAs, epigenetics and complexity
Costa, F. F. (2007) · Gene · doi:10.1016/j.gene.2007.12.008 · Cited by 334
Heckman, J. J. (2008) · National Bureau of Economic Research · doi:10.3386/w14064 · Cited by 331
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
Teschendorff, A. E., West, J., & Beck, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt375 · Cited by 330
The role of epigenetics in aging and age-related diseases
Calvanese, V., Lara, E., Kahn, A., & Fraga, M. F. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.004 · Cited by 329
Self-citationEpigenetic factors in aging and longevity
Gravina, S., & Vijg, J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0730-7 · Cited by 329
Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328
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Ho, S., Johnson, A. D., Tarapore, P., Janakiram, V., Zhang, X., & Leung, Y. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.289 · Cited by 327
DNA methylation in white blood cells
Terry, M. B., Delgado‐Cruzata, L., Vin‐Raviv, N., Wu, H. C., & Santella, R. M. (2011) · Epigenetics · doi:10.4161/epi.6.7.16500 · Cited by 326
Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives
Milagro, F. I., Mansego, M. L., de Miguel, C., & Martínez, J. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.010 · Cited by 323
DNA Methylation Biomarkers in Aging and Age-Related Diseases
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The emerging science of epigenomics
Callinan, P. A., & Feinberg, A. P. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl095 · Cited by 321
Cortessis, V. K., Thomas, D. C., Levine, A. J., Breton, C. V., Mack, T. M., Siegmund, K. D., Haile, R. W., & Laird, P. W. (2012) · Human Genetics · doi:10.1007/s00439-012-1189-8 · Cited by 319
Ollikainen, M., Smith, K. R., Joo, E. J.-H., Ng, H. K., Andronikos, R. H., Novakovic, B., Aziz, N. K. A., Carlin, J. B., Morley, R., Saffery, R., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq336 · Cited by 320
Manifestations and mechanisms of stem cell aging
Liu, L. A., & Rando, T. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010131 · Cited by 318
Talens, R. P., Boomsma, D. I., Tobi, E. W., Kremer, D., Jukema, J. W., Willemsen, G. A. H. M., Putter, H., Slagboom, P. E., & Heijmans, B. T. (2010) · The FASEB Journal · doi:10.1096/fj.09-150490 · Cited by 317
Aging, inflammation, immunity and periodontal disease
Ebersole, J. L., Graves, C. L., González, O. A., Dawson, D. R., Morford, L. A., Emecen‐Huja, P., Hartsfield, J. K., Huja, S. S., Pandruvada, S. N. M., & Wallet, S. M. (2016) · Periodontology 2000 · doi:10.1111/prd.12135 · Cited by 315
Transgenerational epigenetic inheritance: More questions than answersPreprint
Daxinger, L., & Whitelaw, E. (2010) · Genome Research · doi:10.1101/gr.106138.110 · Cited by 314
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Molecular studies of major depressive disorder: the epigenetic perspective
Mill, J. S., & Petronis, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001992 · Cited by 311
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Ma, W. W., & Adjei, A. A. (2009) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20003 · Cited by 310
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Dick, D. M. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104518 · Cited by 311
Brooks, W. H., Dantec, C. L., Pers, J., Youinou, P., & Renaudineau, Y. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.12.006 · Cited by 307
Tost, J. (2009) · Molecular Biotechnology · doi:10.1007/s12033-009-9216-2 · Cited by 306
von Hertzen, L., Hanski, I., & Haahtela, T. (2011) · The EMBO Reports · doi:10.1038/embor.2011.195 · Cited by 304
Pietiläinen, K. H., Naukkarinen, J., Rissanen, A., Saharinen, J., Ellonen, P., Keränen, H., Suomalainen, A., Götz, A., Suortti, T., Yki‐Järvinen, H., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050051 · Cited by 303
Talens, R. P., Christensen, K., Putter, H., Willemsen, G., Christiansen, L., Kremer, D., Suchiman, H. E. D., Slagboom, P. E., Boomsma, D. I., & Heijmans, B. T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00835.x · Cited by 300
Seow, W. K. (2013) · Australian Dental Journal · doi:10.1111/adj.12104 · Cited by 300
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Ropero, S., Fraga, M. F., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setién, F., Paz, M. F., et al. (2006) · Nature Genetics · doi:10.1038/ng1773 · Cited by 300
Self-citationEpigenetics meets endocrinology
Zhang, X., & Ho, S. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0053 · Cited by 300
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Lauc, G., & Zoldoš, V. (2010) · Molecular BioSystems · doi:10.1039/c0mb00067a · Cited by 299
Statistical and integrative system-level analysis of DNA methylation data
Teschendorff, A. E., & Relton, C. L. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.86 · Cited by 297
Schizophrenia: a common disease caused by multiple rare alleles
McClellan, J. M., Susser, E., & King, M.-C. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.025585 · Cited by 296
Recognizing resilience: Learning from the effects of stress on the brain
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.001 · Cited by 292
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Desai, M., Jellyman, J. K., & Ross, M. G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.13 · Cited by 289
Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015407 · Cited by 288
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Edgren, G., Liang, L., Adami, H., & Chang, E. T. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-011-9647-5 · Cited by 286
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Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283
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Movassagh, M., Choy, M., Knowles, D. A., Cordeddu, L., Haider, S. A., Down, T. A., Siggens, L., Vujić, A., Simeoni, I., Penkett, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.040071 · Cited by 281
Epigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277
El‐Maarri, O., Becker, T., Junen, J., Manzoor, S. S., Diaz-Lacava, A. N., Schwaab, R., Wienker, T. F., & Oldenburg, J. (2007) · Human Genetics · doi:10.1007/s00439-007-0430-3 · Cited by 276
Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity
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Gordon, L., Joo, J. E., Powell, J. E., Ollikainen, M., Novakovic, B., Li, X., Andronikos, R. H., Cruickshank, M. N., Conneely, K. N., Smith, A. K., et al. (2012) · Genome Research · doi:10.1101/gr.136598.111 · Cited by 276
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Metadata
- Authors
- Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., Boix-Chornet, M., Sanchez-Aguilera, A., Ling, C., Carlsson, E., Poulsen, P., Vaag, A., Stephan, Z., Spector, T. D., Wu, Y.-Z., Plass, C., & Esteller, M.
- Affiliations
- Universitat de València (ES)
- Epigenetics, Cytogenetics, and Genetic Laboratories, Spanish National Cancer Centre (CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain; Department of Behavioral Science, University of Valencia, 46010 Valencia, Spain; Molecular Genetics Laboratory, Genetics Department, Son Dureta Hospital, 07014 Palma de Mallorca, Spain; Department of Clinical Sciences, University Hospital Malmö, Lund University, S-205 02 Malmö, Sweden; Steno Diabetes Center, 2820 Gentofte, Denmark; Twin Research and Genetic...
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-07-11
- Volume
- 102
- Issue
- 30
- Pages
- 10604-10609
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1174919
- OpenAlex
- W2134555277
- Cited by
- 3,602
- References
- 20
- Citations by year
- 2026: 65 · 2025: 87 · 2024: 113 · 2023: 115 · 2022: 143 · 2021: 119 · 2020: 147 · 2019: 161 · 2018: 185 · 2017: 173 · 2016: 191 · 2015: 225 · 2014: 223 · 2013: 242 · 2012: 293
- FWCI
- 51.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Hispana (submittedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- monozygotic twins, epigenetic variation, DNA methylation, histone acetylation, 5-methylcytosine, phenotypic discordance, gene expression, aging
- MeSH terms
- Acetylation, Adult, Analysis of Variance, Female, Histones, Humans, Male, Phenotype, Surveys and Questionnaires, Spain, Twins, Monozygotic, Restriction Mapping, Sequence Analysis, DNA, Gene Expression Regulation, Developmental, Electrophoresis, Capillary, DNA Methylation, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Nucleic Acid Amplification Techniques, Epigenesis, Genetic, 5-Methylcytosine, X Chromosome Inactivation
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