The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Epigenetic differences arise during the lifetime of monozygotic twins
Open accessAbstract
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“genetics alone do not account for most of the risk of major depression.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [17]
Experimental — accuracy not yet measuredIn the citing paper
“Environmental conditions clearly influence epigenetic profiles in human immune cells [37], and some studies have begun to link immune cell DNA methylation profiles to specific social environmental conditions such as low social status [7] and early life stress exposure [38]–[41].”
From Human Social Genomics (2014) · cites this paper as [37]
In the citing paper
“Identical twin studies have shown a high discordance rate for MDD of 50%, indicating the importance of non-genetic factors.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [4]
In the citing paper
“Studies with monozygotic twins suggest the accumulation of epigenetic changes as twins age (e.g., demethylation of 5-methylcytosines in DNA), thus affecting the transcriptome (Fraga et al., 2005).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Fraga et al., 2005
In the citing paper
“For example, identical twins diverge over the life course in patterns of CpG methylation of their DNA reflecting the influence of “non-shared” experiences.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926
Self-citationAllen, R. C., Zoghbi, H. Y., Moseley, A., Rosenblatt, H. M., & Belmont, J. W. (1992) · PubMed · Cited by 1,683
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Nuclear Cloning and Epigenetic Reprogramming of the Genome
Rideout, W. M., Eggan, K. C., & Jaenisch, R. (2001) · Science · doi:10.1126/science.1063206 · Cited by 756
A Twin Study of Genetic Relationships Between Psychotic Symptoms
Cardno, A. G., Rijsdijk, F. V., Sham, P. C., Murray, R. M., & McGuffin, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.539 · Cited by 460
An integrated epigenetic and genetic approach to common human disease
BJORNSSON, H. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.009 · Cited by 448
Phenotypic differences in genetically identical organisms: the epigenetic perspective.
Wong, A., Gottesman, I., & Petronis, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi116 · Cited by 438
Weksberg, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1317 · Cited by 329
Epigenetics and Assisted Reproductive Technology: A Call for Investigation
Niemitz, E. L., & Feinberg, A. P. (2004) · The American Journal of Human Genetics · doi:10.1086/382897 · Cited by 328
Research works printed but not linked: 4
- Hall J. G. & Lopez-Rangel E. (1966) in Twins and Twinning eds. Emery A. E. H. & Rimoin D. L. (Churchill Livingstone New York) pp. 395-404.
- Becker, A., Busjahn, A., Faulhaber, H. D., Bahring, S., Robertson, J., Schuster H. & Luft, F. C. (1997) J. Reprod. Med. 42, 260-266.9172114
- Allen, R. C., Zoghbi, H. Y., Moseley, A. B., Rosenblatt, H. M. & Belmont, J. W. (1992) Am. J. Hum. Genet. 51, 1229-1239.1281384
- Cooney, C. A. (1993) Growth. Dev. Aging 57, 261-273.8300279
Cited by
Sorted by citations
Items 801–900 of 1,011
Terry, D. M., & Devine, S. E. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01244 · Cited by 76
Balestrieri, E., Pica, F., Matteucci, C., Zenobi, R., Sorrentino, R., Argaw-Denboba, A., Cipriani, C., Bucci, I., & Vallebona, P. S. (2015) · BioMed Research International · doi:10.1155/2015/164529 · Cited by 76
The fate is not always written in the genes: Epigenomics in epidemiologic studies
Langevin, S. M., & Kelsey, K. T. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21762 · Cited by 75
Maiti, S., Kumar, K. H. B. G., Castellani, C. A., O’Reilly, R., & Singh, S. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017125 · Cited by 75
A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice
Li, C. C. Y., Cropley, J. E., Cowley, M. J., Preiß, T., Martin, D. I. K., & Suter, C. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001380 · Cited by 75
Global DNA promoter methylation in frontal cortex of alcoholics and controls
Manzardo, A. M., Henkhaus, R. S., & Butler, M. G. (2012) · Gene · doi:10.1016/j.gene.2012.01.096 · Cited by 75
Somatic point mutations occurring early in development: a monozygotic twin study
Li, R., Montpetit, A., Rousseau, M., Wu, S., Greenwood, C. M. T., Spector, T. D., Pollak, M., Polychronakos, C., & Richards, J. B. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-101712 · Cited by 75
Self-citationIschemic stroke patients are biologically older than their chronological age
Soriano‐Tárraga, C., Steinhauer, E. G., Mola-Caminal, M., Vivanco‐Hidalgo, R. M., Ois, Á., Rodríguez-Campello, A., Cuadrado‐Godia, E., Sayols-Baixeras, S., Elosúa, R., Roquer, J., et al. (2016) · Aging · doi:10.18632/aging.101028 · Cited by 75
Silventoinen, K., Pietiläinen, K. H., Tynelius, P., Sørensen, T. I. A., Kaprio, J. A., & Rasmussen, F. E. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803577 · Cited by 74
Familial Asymptomatic Macular Telangiectasia Type 2
Gillies, M. C., Zhu, M., Chew, E. Y., Barthelmes, D., Hughes, E. H., Ali, H., Holz, F. G., Scholl, H. P. N., & Issa, P. C. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.05.010 · Cited by 74
Folate and long-chain polyunsaturated fatty acids in psychiatric disease
Muskiet, F. A. J., & Kemperman, R. F. J. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.001 · Cited by 74
Fisel, P., Schaeffeler, E., & Schwab, M. G. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.343 · Cited by 74
The epigenetic landscape of age-related diseases: the geroscience perspective
Gensous, N., Bacalini, M. G., Pirazzini, C., Marasco, E., Giuliani, C., Ravaioli, F., Mengozzi, G., Bertarelli, C., Palmas, M. G., Franceschi, C., et al. (2017) · Biogerontology · doi:10.1007/s10522-017-9695-7 · Cited by 74
Islam, S. A., Goodman, S. J., MacIsaac, J. L., Obradović, J., Barr, R. G., Boyce, W. T., & Kobor, M. S. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0245-6 · Cited by 74
The Use of Mouse Models to Study EpigeneticsPreprint
Blewitt, M., & Whitelaw, E. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017939 · Cited by 74
Epigenetics in asthma and COPD
Kabesch, M., & Adcock, I. M. (2012) · Biochimie · doi:10.1016/j.biochi.2012.07.017 · Cited by 73
Targeting the molecular & cellular pillars of human aging with exercise
Goh, J., Wong, E. S. P., Soh, J., Maier, A. B., & Kennedy, B. K. (2021) · FEBS Journal · doi:10.1111/febs.16337 · Cited by 73
Sahafnejad, Z., Ramazi, S., & Allahverdi, A. (2023) · Genes · doi:10.3390/genes14040873 · Cited by 73
Hunting for the 5th base: Techniques for analyzing DNA methylation
Ammerpohl, O., Martín-Subero, J. I., Richter, J., Vater, I., & Siebert, R. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.001 · Cited by 73
Pancreatic cancerDNMT1expression and sensitivity toDNMT1inhibitors
Li, A., Omura, N., Hong, S., & Goggins, M. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.4.10750 · Cited by 73
Kegley, K. M., Sellers, M., Ferber, M. J., Johnson, M. W., Joelson, D. W., & Shrestha, R. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03071.x · Cited by 73
Ong, M., & Holbrook, J. D. (2013) · Aging Cell · doi:10.1111/acel.12159 · Cited by 73
Parent-of-origin effects in MS
Herrera, B. M., Ramagopalan, S. V., Lincoln, M. R., Orton, S. M., Chao, M., Sadovnick, A. D., & Ebers, G. C. (2008) · Neurology · doi:10.1212/01.wnl.0000312377.50395.00 · Cited by 73
Chemical and biochemical approaches in the study of histone methylation and demethylation
Li, K. K., Luo, C., Wang, D., Jiang, H., & Zheng, Y. G. (2010) · Medicinal Research Reviews · doi:10.1002/mrr.20228 · Cited by 73
Marusyk, A., & DeGregori, J. V. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.09.001 · Cited by 73
Cevenini, E., Bellavista, E., Tieri, P., Castellani, G., Lescai, F., Francesconi, M., Mishto, M., Santoro, A., Valensin, S., Salvioli, S., et al. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883660 · Cited by 73
Esteller, M. (2011) · F1000 Biology Reports · doi:10.3410/b3-9 · Cited by 73
Self-citationD’Aquila, P., Rose, G., Bellizzi, D., & Passarino, G. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.11.005 · Cited by 73
Interplay Between Social Experiences and the Genome: Epigenetic Consequences for Behavior
Champagne, F. A. (2012) · Advances in genetics · doi:10.1016/b978-0-12-387687-4.00002-7 · Cited by 73
Uwineza, A., Kalligeraki, A. A., Hamada, N., Jarrı́n, M., & Quinlan, R. A. (2019) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2019.02.004 · Cited by 73
Benign occipital epilepsies of childhood: clinical features and genetics
Taylor, I., Berkovic, S. F., Kivity, S., & Scheffer, I. E. (2008) · Brain · doi:10.1093/brain/awn138 · Cited by 73
Garg, P., Joshi, R. S., Watson, C. T., & Sharp, A. J. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007707 · Cited by 73
Can we observe epigenetic effects on human brain function?
Nikolova, Y. S., & Hariri, A. R. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.003 · Cited by 73
Masterpasqua, F. (2009) · Review of General Psychology · doi:10.1037/a0016301 · Cited by 72
The role of vitamins and minerals in modulating the expression of microRNA
Beckett, E., Yates, Z. R., Veysey, M. J., Duesing, K., & Lucock, M. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000043 · Cited by 72
Role of epigenetic mechanisms in the development of chronic complications of diabetes
Wegner, M., Neddermann, D., Pioruńska-Stolzmann, M., & Jagodziński, P. P. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.03.019 · Cited by 72
Multiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype
Lonergan, R., Kinsella, K., Fitzpatrick, P., Brady, J. J., Murray, B., Dunne, C., Hagan, R., Duggan, M., Jordan, S., McKenna, M. J., et al. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.220988 · Cited by 72
Li, Y., & Tollefsbol, T. O. (2016) · Epigenomics · doi:10.2217/epi-2016-0078 · Cited by 72
Gavery, M. R., Nichols, K. M., Goetz, G., Middleton, M. A., & Swanson, P. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200458 · Cited by 72
DNA methylation processes in atherosclerotic plaque
Aavik, E., Babu, M., & Ylä‐Herttuala, S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.006 · Cited by 72
Brena, R. M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gnj017 · Cited by 72
Insights into assessing the genetics of endometriosis
Rahmioglu, N., Missmer, S. A., Montgomery, G. W., & Zondervan, K. T. (2012) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-012-0016-5 · Cited by 71
Wu, H., Delgado‐Cruzata, L., Flom, J. D., Perrin, M. C., Liao, Y., Ferris, J. S., Santella, R. M., & Terry, M. B. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs201 · Cited by 71
Slagboom, P. E., Beekman, M., Passtoors, W. M., Deelen, J., Vaarhorst, A. A. M., Boer, J. M., van den Akker, E. B., van Heemst, D., de Craen, A. J. M., Maier, A. B., et al. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0284 · Cited by 71
Epigenetics: differential DNA methylation in mammalian somatic tissues
Nagase, H., & Ghosh, S. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06330.x · Cited by 71
Gomes, M. V., Toffoli, L. V., Arruda, D. W., Soldera, L. M., Pelosi, G. G., das Neves-Souza, R. D., de Freitas, E. R. F. S., Castro, D. T., & Marquez, A. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052570 · Cited by 71
Cancer Epigenetics for the 21st Century: What's Next?
Esteller, M. (2011) · Genes & Cancer · doi:10.1177/1947601911423096 · Cited by 71
Self-citationDNA Hypermethylation of ESR1 and PGR in Breast Cancer: Pathologic and Epidemiologic Associations
Gaudet, M. M., Campan, M., Figueroa, J. D., Yang, X. R., Lissowska, J., Pepłońska, B., Brinton, L. A., Rimm, D. L., Laird, P. W., García‐Closas, M., et al. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0678 · Cited by 71
Cath, D. C., Grootheest, D. S. V., Willemsen, G. A. H. M., van Oppen, P., & Boomsma, D. I. (2008) · Behavior Genetics · doi:10.1007/s10519-007-9185-9 · Cited by 71
Smirnova, L. (2015) · ALTEX · doi:10.14573/altex.1509271 · Cited by 71
The frail renin–angiotensin system
Abadir, P. M. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.08.004 · Cited by 70
de Geus, E. J. C., Ent, D. V. ‘., Wolfensberger, S. P. A., Heutink, P., Hoogendijk, W. J. G., Boomsma, D. I., & Veltman, D. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.026 · Cited by 70
Immunosenescence, Aging, and Systemic Lupus Erythematous
Montoya-Ortiz, G. (2013) · Autoimmune Diseases · doi:10.1155/2013/267078 · Cited by 70
Reduced telomere length variation in healthy oldest old
Halaschek-Wiener, J., Vulto, I. M., Fornika, D., Collins, J. A., Connors, J. M., Le, N. D., Lansdorp, P. M., & Brooks-Wilson, A. R. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.07.004 · Cited by 70
Epigenetics and periodontal disease: future perspectives
Gomez, R. S., Dutra, W. O., & Moreira, P. R. (2009) · Inflammation Research · doi:10.1007/s00011-009-0041-7 · Cited by 70
Early-life nutritional programming of longevity
Vaiserman, A. M. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000294 · Cited by 70
Genetics and Peer Relations: A Review
Brendgen, M. R. (2012) · Journal of Research on Adolescence · doi:10.1111/j.1532-7795.2012.00798.x · Cited by 70
Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry
Gupta, J., Johansson, E., Bernstein, J. A., Chakraborty, R., Hershey, G. K. K., Rothenberg, M. E., & Baye, T. M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.045 · Cited by 70
DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging
Lewis, S., Nachun, D. C., Martı́n, M. G., Horvath, S., Coppola, G., & Jones, D. L. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.11.013 · Cited by 70
Leffers, H. C. B., Lange, T., Collins, C. E., Ulff-Møller, C. J., & Jacobsen, S. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.11.005 · Cited by 69
Defining the toxicology of aging
Sorrentino, J. A., Sanoff, H. K., & Sharpless, N. E. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.04.004 · Cited by 69
Epigenetic Genome-Wide Association Methylation in Aging and Longevity
Ben‐Avraham, D., Muzumdar, R. H., & Atzmon, G. (2012) · Epigenomics · doi:10.2217/epi.12.41 · Cited by 69
Variable expression of neurofibromatosis 1 in monozygotic twins
Rieley, M. B., Stevenson, D. A., Viskochil, D. H., Tinkle, B. T., Martin, L. J., & Schorry, E. K. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33851 · Cited by 69
Guéant, J., Akoum, R. E., Ziegler, O., Coelho, D., Feigerlová, E., Daval, J., & Guéant‐Rodriguez, R. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1339-4 · Cited by 69
Epigenetics and developmental plasticity across species
Champagne, F. A. (2012) · Developmental Psychobiology · doi:10.1002/dev.21036 · Cited by 69
DNA methylation, epimutations and cancer predisposition
Dobrovic, A., & Kristensen, L. S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.09.006 · Cited by 69
Toxicogenomic profiling of chemically exposed humans in risk assessment
McHale, C. M., Zhang, L., Hubbard, A., & Smith, M. T. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.04.001 · Cited by 69
Feng, L., Peng, F., Li, S., Jiang, L., Sun, H., Ji, A., Zeng, C., Li, C., & Liu, F. (2018) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2018.03.009 · Cited by 69
Duforestel, M., Nadaradjane, A., Bougras-Cartron, G., Briand, J., Olivier, C., Frenel, J., Vallette, F. M., Lelièvre, S. A., & Cartron, P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00885 · Cited by 69
Environmental exposure and mitochondrial epigenetics: study design and analytical challenges
Byun, H.-M., & Baccarelli, A. A. (2014) · Human Genetics · doi:10.1007/s00439-013-1417-x · Cited by 68
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Li, S., Nguyen, T. L., Wong, E. M., Dugué, P., Dite, G. S., Armstrong, N. J., Craig, J. M., Mather, K. A., Sachdev, P. S., Saffery, R., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00950-1 · Cited by 68
Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition
Milošević, M. S., Arsić, A., Cvetković, Z., & Vučić, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.688086 · Cited by 68
Gavin, D. P., Kartan, S., Chase, K. A., Grayson, D. R., & Sharma, R. P. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.026 · Cited by 68
Martin, L. J., & Wong, M. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0205-6 · Cited by 68
Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents
Jeffries, M. A., & Sawalha, A. H. (2011) · International Journal of Clinical Rheumatology · doi:10.2217/ijr.11.32 · Cited by 68
Male Reproductive Cancers and Infertility: A Mutual Relationship
Tvrdá, E., Agarwal, A. K., & Alkuhaimi, N. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047230 · Cited by 68
The role of epigenetic mechanisms and processes in autoimmune disorders
Greer, J. M., & McCombe, P. (2012) · Biologics · doi:10.2147/btt.s24067 · Cited by 68
Johnson, K. C., Koestler, D. C., Cheng, C., & Christensen, B. C. (2013) · Epigenetics · doi:10.4161/epi.27015 · Cited by 68
Validation of suitable internal control genes for expression studies in aging
Zampieri, M., Ciccarone, F., Guastafierro, T., Bacalini, M. G., Calabrese, R., Moreno‐Villanueva, M., Reale, A., Chevanne, M., Bürkle, A., & Caiafa, P. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.005 · Cited by 68
Nilsson, E., & Ling, C. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0399-2 · Cited by 68
Self-citationAn Introduction to Epigenetics
Ballestar, E. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8216-2_1 · Cited by 67
Self-citationNext-generation sequencing and epigenome technologies: potential medical applications
Roukos, D. H. (2010) · Expert Review of Medical Devices · doi:10.1586/erd.10.68 · Cited by 67
Körholz, J., Zocher, S., Grzyb, A. N., Morisse, B., Poetzsch, A., Ehret, F., Schmied, C., & Kempermann, G. (2018) · eLife · doi:10.7554/elife.35690 · Cited by 66
Early Nutrition: Impact on Epigenetics
Mathers, J. C. (2007) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000107066 · Cited by 67
Yu, B., RUSSANOVA, V. R., Gravina, S., Hartley, S. W., Mullikin, J. C., Ignezweski, A., Graham, J., Segars, J. H., DeCherney, A. H., & Howard, B. H. (2015) · Oncotarget · doi:10.18632/oncotarget.2875 · Cited by 67
Epigenetic Modification of the X Chromosome Influences Susceptibility to Polycystic Ovary Syndrome
Hickey, T. E., Legro, R. S., & Norman, R. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0069 · Cited by 67
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth
Lévesque, M. L., Casey, K. F., Szyf, M., Ismaylova, E., Ly, V., Verner, M., Suderman, M. J., Brendgen, M. R., Vitaro, F., Dionne, G., et al. (2014) · Epigenetics · doi:10.4161/15592294.2014.970060 · Cited by 67
Schaevitz, L. R., & Berger-Sweeney, J. E. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.322 · Cited by 67
DNA methylation changes elicited by social stimuli in the brains of worker honey bees
Lockett, G. A., Kucharski, R., & Maleszka, R. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00751.x · Cited by 67
Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome
Kunio, M., Yang, C., Minakuchi, Y., Ohori, K., Soutome, M., Hirasawa, T., Kazuki, Y., Adachi, N., Suzuki, S., Itoh, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066729 · Cited by 67
The role of pharmacogenetics in the treatment of depression and anxiety disorders
Schosser, A., & Kasper, S. F. (2009) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e3283306a2f · Cited by 67
Genome–epigenome interactions in cancer
Brena, R. M., & Costello, J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm073 · Cited by 67
Kaut, O., Schmitt, I., Tost, J., Busato, F., Liu, Y., Hofmann, P., Witt, S. H., Rietschel, M., Fröhlich, H., & Wüllner, U. (2016) · Neurogenetics · doi:10.1007/s10048-016-0497-x · Cited by 67
RNA as the substrate for epigenome‐environment interactions
Mattick, J. S. (2010) · BioEssays · doi:10.1002/bies.201000028 · Cited by 67
Linnenbringer, E. L., Gehlert, S. J., & Geronimus, A. T. (2017) · AIMS Public Health · doi:10.3934/publichealth.2017.5.526 · Cited by 67
The biological age of the heart is consistently younger than chronological age
Pavanello, S., Campisi, M., Fabozzo, A., Cibin, G., Tarzia, V., Toscano, G., & Gerosa, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-67622-1 · Cited by 66
Physiological Systems in Promoting Frailty
Perazza, L. R., Brown‐Borg, H. M., & Thompson, L. V. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210034 · Cited by 69
Advancing translational exposomics: bridging genome, exposome and personalized medicine
Sarigiannis, D. A., Karakitsios, S., Anesti, O., Stem, A. D., Valvi, D., Sumner, S., Chatzi, L., Snyder, M. P., Thompson, D. C., & Vasiliou, V. (2025) · Human Genomics · doi:10.1186/s40246-025-00761-6 · Cited by 66
Tissue-specific variation in DNA methylation levels along human chromosome 1
de Bustos, C., Ramos, E., Young, J. M., Tran, R. K., Menzel, U., Langford, C. F., Eichler, E. E., Hsu, L.-I., Henikoff, S., Dumanski, J. P., et al. (2009) · Epigenetics & Chromatin · doi:10.1186/1756-8935-2-7 · Cited by 66
Hematopoiesis is not clonal in healthy elderly women
Swierczek, S. I., Agarwal, N., Nussenzveig, R. H., Rothstein, G., Wilson, A. R., Artz, A. S., & Prchal, J. T. (2008) · Blood · doi:10.1182/blood-2008-03-143925 · Cited by 66
Metadata
- Authors
- Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., Boix-Chornet, M., Sanchez-Aguilera, A., Ling, C., Carlsson, E., Poulsen, P., Vaag, A., Stephan, Z., Spector, T. D., Wu, Y.-Z., Plass, C., & Esteller, M.
- Affiliations
- Universitat de València (ES)
- Epigenetics, Cytogenetics, and Genetic Laboratories, Spanish National Cancer Centre (CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain; Department of Behavioral Science, University of Valencia, 46010 Valencia, Spain; Molecular Genetics Laboratory, Genetics Department, Son Dureta Hospital, 07014 Palma de Mallorca, Spain; Department of Clinical Sciences, University Hospital Malmö, Lund University, S-205 02 Malmö, Sweden; Steno Diabetes Center, 2820 Gentofte, Denmark; Twin Research and Genetic...
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-07-11
- Volume
- 102
- Issue
- 30
- Pages
- 10604-10609
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1174919
- OpenAlex
- W2134555277
- Cited by
- 3,602
- References
- 20
- Citations by year
- 2026: 65 · 2025: 87 · 2024: 113 · 2023: 115 · 2022: 143 · 2021: 119 · 2020: 147 · 2019: 161 · 2018: 185 · 2017: 173 · 2016: 191 · 2015: 225 · 2014: 223 · 2013: 242 · 2012: 293
- FWCI
- 51.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Hispana (submittedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- monozygotic twins, epigenetic variation, DNA methylation, histone acetylation, 5-methylcytosine, phenotypic discordance, gene expression, aging
- MeSH terms
- Acetylation, Adult, Analysis of Variance, Female, Histones, Humans, Male, Phenotype, Surveys and Questionnaires, Spain, Twins, Monozygotic, Restriction Mapping, Sequence Analysis, DNA, Gene Expression Regulation, Developmental, Electrophoresis, Capillary, DNA Methylation, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Nucleic Acid Amplification Techniques, Epigenesis, Genetic, 5-Methylcytosine, X Chromosome Inactivation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
