The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis
Open accessAbstract
Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. Here, we established its involvement in the control of adipogenesis and lipid metabolism activity in mature adipocytes. During adipose differentiation in 3T3-L1 cells, the level of BMAL1 mRNA began to increase 4 days after induction and was highly expressed in differentiated cells. In white adipose tissues isolated from C57BL/6J mice, BMAL1 was predominantly expressed in a fraction containing adipocytes, as compared with the stromal-vascular fraction. BMAL1 knockout mice embryonic fibroblast cells failed to be differentiated into adipocytes. Importantly, adding BMAL1 back by adenovirus gene transfer restored the ability of BMAL1 knockout mice embryonic fibroblast cells to differentiate. Knock-down of BMAL1 expression in 3T3-L1 cells by an RNA interference technique allowed the cells to accumulate only minimum amounts of lipid droplets in the cells. Adenovirus-mediated expression of BMAL1 in 3T3-L1 adipocytes resulted in induction of several factors involved in lipogenesis. The promoter activity of these genes was stimulated in a BMAL1-dependent manner. Interestingly, expression of these factors showed clear circadian rhythm in mice adipose tissue. Furthermore, overexpression of BMAL1 in adipocytes increased lipid synthesis activity. These results indicate that BMAL1, a master regulator of circadian rhythm, also plays important roles in the regulation of adipose differentiation and lipogenesis in mature adipocytes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Knockout of Bmal1 alone in C57BL/6J mice showed that isolated mouse embryonic fibroblast (MEF) cells could not successfully differentiate into adipocytes (Shimba et al., 2005).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Shimba et al., 2005
In the citing paper
“The presence of high Bmal1 mRNA levels in adipocytes increased lipogenesis activity, further suggesting that Bmal1 is involved in regulating lipid metabolism.”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Shimba et al., 2005
In the citing paper
“Further, restoration of Bmal1 function by adenovirus gene transfer into the initial Bmal1-deficient mice restored adipocyte differentiation and lipid accumulation in the MEF cells.”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Shimba et al., 2005
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621
Adipose Tissue as an Endocrine Organ
Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608
Time zones: a comparative genetics of circadian clocks
Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,159
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059
Flagged first, then by citations
Research works printed but not linked: 2
- Gagliardino, J. J. & Hernandez, R. E. (1971) Endocrinology 88, 1532–1534.5572981
- Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B. & FitGerald, G. A. (2004) PLoS Biol. 2, 1893–1899.
Cited by
Sorted by citations
Items 101–200 of 533
Bifunctional Role of Rev-erbα in Adipocyte Differentiation
Wang, J., & Lazar, M. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01608-07 · Cited by 121
Impaired Glucocorticoid Production and Response to Stress in Arntl-Deficient Male Mice
Leliavski, A., Shostak, A., Husse, J., & Oster, H. (2013) · Endocrinology · doi:10.1210/en.2013-1531 · Cited by 118
The Circadian Clock Maintains Cardiac Function by Regulating Mitochondrial Metabolism in Mice
Kohsaka, A., Das, P., Hashimoto, I., Nakao, T., Deguchi, Y., Gouraud, S. S., Waki, H., Muragaki, Y., & Maeda, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112811 · Cited by 124
Skipping Breakfast is Correlated with Obesity
Watanabe, Y., Saito, I., Henmi, I., Yoshimura, K., Maruyama, K., Yamauchi, K., Matsuo, T., Kato, T., Tanigawa, T., Kishida, T., et al. (2014) · Journal of Rural Medicine · doi:10.2185/jrm.2887 · Cited by 119
Interactions between metabolism and circadian clocks: reciprocal disturbances
Delezie, J., & Challet, É. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06246.x · Cited by 124
Ramsey, K. M., Marcheva, B., Kohsaka, A., & Bass, J. T. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093546 · Cited by 120
Circadian Clock Regulates Bone Resorption in Mice
Xu, C., Ochi, H., Fukuda, T., Sato, S., Sunamura, S., Takarada, T., Hinoi, E., Okawa, A., & Takeda, S. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2803 · Cited by 117
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115
Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling
Zhang, D., Tong, X., Arthurs, B., Guha, A., Rui, L., Kamath, A., Inoki, K., & Yin, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567628 · Cited by 115
PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1
Wang, S., Lin, Y., Gao, L., Yang, Z., Lin, J., Ren, S., Li, F., Chen, J., Wang, Z., Dong, Z., et al. (2022) · Theranostics · doi:10.7150/thno.69054 · Cited by 119
Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing?
Pilorz, V., & Steinlechner, S. (2008) · Reproduction · doi:10.1530/rep-07-0434 · Cited by 114
Sun, L., Wang, Y., Song, Y., Cheng, X., Xia, S., Rahman, M. R. T., Shi, Y., & Le, G. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.072 · Cited by 111
Hsieh, M.-C., Yang, S.-C., Tseng, H.-L., Hwang, L.-L., Chen, C.-T., & Shieh, K.-R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.228 · Cited by 108
The hypothalamic clock and its control of glucose homeostasis
Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.005 · Cited by 112
Otway, D. T., Mäntele, S., Bretschneider, S., Wright, J., Trayhurn, P., Skene, D. J., Robertson, M. D., & Johnston, J. D. (2011) · Diabetes · doi:10.2337/db10-1098 · Cited by 110
The role of cell‐specific circadian clocks in metabolism and disease
Bray, M. S., & Young, M. E. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00684.x · Cited by 106
Stenvers, D. J., Jongejan, A., Atiqi, S., Vreijling, J. P., Limonard, E. J., Endert, E., Baas, F., Moerland, P. D., Fliers, E., Kalsbeek, A., et al. (2019) · Diabetologia · doi:10.1007/s00125-019-4813-5 · Cited by 105
Differential effects of dietary flavonoids on adipogenesis
Khalilpourfarshbafi, M., Gholami, K., Murugan, D. D., Sattar, M. Z. A., & Abdullah, N. A. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1663-8 · Cited by 112
Kim, E., Lim, S., Park, J., Seo, J. K., Kim, J. H., Kim, K., Ryu, S. H., & Suh, P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22892 · Cited by 106
A Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock
Kovac, J., Husse, J., & Oster, H. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0113-0 · Cited by 104
Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription
Oishi, Y., Hayashi, S., Isagawa, T., Oshima, M., Iwama, A., Shimba, S., Okamura, H., & Manabe, I. (2017) · Scientific Reports · doi:10.1038/s41598-017-07100-3 · Cited by 102
Self-citationClock Genes Influence Gene Expression in Growth Plate and Endochondral Ossification in Mice
Takarada, T., Kodama, A., Hotta, S., Mieda, M., Shimba, S., Hinoi, E., & Yoneda, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.408963 · Cited by 103
Self-citationAkagi, R., Akatsu, Y., Fisch, K. M., Alvarez-Garcia, O., Teramura, T., Muramatsu, Y., Saito, M., Sasho, T., Su, A. I., & Lotz, M. K. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.11.007 · Cited by 97
Stem cells and the circadian clock
Weger, M., Diotel, N., Dorsemans, A.-C., Dickmeis, T., & Weger, B. D. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.012 · Cited by 101
Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology
Bolshette, N. B., Ibrahim, H., Reinke, H., & Asher, G. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00792-1 · Cited by 109
Yanagihara, H., Ando, H., Hayashi, Y., Obi, Y., & Fujimura, A. (2006) · Chronobiology International · doi:10.1080/07420520600827103 · Cited by 99
Circadian Clocks, Food Intake, and Metabolism
Challet, É. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00005-1 · Cited by 103
Fujihara, Y., Kondo, H., Noguchi, T., & Togari, A. (2014) · Bone · doi:10.1016/j.bone.2013.12.026 · Cited by 99
The circadian clock and metabolic homeostasis: entangled networks
de Assis, L. V. M., & Oster, H. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03800-2 · Cited by 104
Alonso‐Vale, M. I. C., Peres, S. B., Vernochet, C., Farmer, S. R., & Lima, F. B. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00705.x · Cited by 92
Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis
Man, A. W. C., Li, H., & Xia, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020676 · Cited by 96
Shimizu, H., Hanzawa, F., Kim, D., Sun, S., Laurent, T., Umeki, M., Ikeda, S., Mochizuki, S., & Oda, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206669 · Cited by 92
MOP3, a component of the molecular clock, regulates the development of B cells
Sun, Y., Yang, Z., Niu, Z., Peng, J., Li, Q., Xiong, W., Langnas, A. N., Ma, M. Y. J., & Zhao, Y. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02456.x · Cited by 90
The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15
Aggarwal, A., Costa, M. J. D. C., Rivero‐Gutiérrez, B., Ji, L., Morgan, S. L., & Feldman, B. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.004 · Cited by 89
The relationship between adipose tissue and bone metabolism
Gimble, J. M., & NUTTALL, M. E. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.03.006 · Cited by 90
Masaki, T., & Yoshimatsu, H. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.03.008 · Cited by 88
Bray, M. S., & Young, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.214643 · Cited by 82
The circadian clock and metabolism
Froy, O. (2010) · Clinical Science · doi:10.1042/cs20100327 · Cited by 86
Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate
Costa, M. J. D. C., So, A. Y., Kaasik, K., Krueger, K. C., Pillsbury, M. L., Fu, Y., Ptáček, L. J., Yamamoto, K. R., & Feldman, B. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164558 · Cited by 83
Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease
Shetty, A., Hsu, J. W., Manka, P. P., & Syn, W. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5242-x · Cited by 85
Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_2 · Cited by 87
Kudo, T., Tamagawa, T., Kawashima, M., Mito, N., & Shibata, S. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407302625 · Cited by 81
Differential Expression of the Circadian Clock in Maternal and Embryonic Tissues of Mice
Dolatshad, H., Cary, A. J., & Davis, F. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009855 · Cited by 81
Chronopharmacology Focused on Biological Clock
Ohdo, S. (2007) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.22.3 · Cited by 79
Systemic PPARγ Deletion Impairs Circadian Rhythms of Behavior and Metabolism
Yang, G., Jia, Z., Aoyagi, T., McClain, D. A., Mortensen, R. M., & Yang, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038117 · Cited by 81
Self-citationOhta, Y., Takenaga, M., Tokura, Y., Hamaguchi, A., Matsumoto, T., Kano, K., Mugishima, H., Okano, H., & Igarashi, R. (2008) · Cell Transplantation · doi:10.3727/096368908786576516 · Cited by 79
Self-citationPotential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism
Sato, F., Kohsaka, A., BHAWAL, U. K., & Muragaki, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030781 · Cited by 85
Oishi, K., Ohkura, N., Wakabayashi, M., Shirai, H., SATO, K., Matsuda, J., Atsumi, G., & Ishida, N. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02032.x · Cited by 79
McGinnis, G. R., Tang, Y., Brewer, R. A., Brahma, M. K., Stanley, H. L., Shanmugam, G., Rajasekaran, N. S., Rowe, G. C., Frank, S. J., Wende, A. R., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.07.005 · Cited by 77
Clock gene dysfunction in patients with obstructive sleep apnoea syndrome
Burioka, N., Koyanagi, S., Endo, M., Takata, M., Fukuoka, Y., Miyata, M., Takeda, K., Chikumi, H., Ohdo, S., & Shimizu, E. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138207 · Cited by 77
Molecular clocks, type 2 diabetes and cardiovascular disease
Prasai, M., George, J. T., & SCOTT, E. M. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.015 · Cited by 76
Chen, H., Zhao, L., Kumazawa, M., Yamauchi, N., Shigeyoshi, Y., Hashimoto, S., & Hattori, M. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00008.2013 · Cited by 77
Melatonin and metabolic regulation: a review
Navarro‐Alarcón, M., Ruiz‐Ojeda, F. J., Blanca-Herrera, R. M., A‐Serrano, M. M., Acuña-Castroviejo, D., Fernández‐Vázquez, G., & Agil, A. (2014) · Food & Function · doi:10.1039/c4fo00317a · Cited by 77
Effects of Fasting and Re-Feeding on the Expression of Dec1, Per1, and Other Clock-Related Genes
Kawamoto, T., Noshiro, M., Furukawa, M., Honda, K. K., Nakashima, A., Ueshima, T., Usui, E., Katsura, Y., Fujimoto, K., Honma, S., et al. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj165 · Cited by 73
The intrinsic microglial clock system regulates interleukin‐6 expression
Nakazato, R., Hotta, S., Yamada, D., Kou, M., Nakamura, S., Takahata, Y., Tei, H., Numano, R., Hida, A., Shimba, S., et al. (2016) · Glia · doi:10.1002/glia.23087 · Cited by 74
Self-citationGotoh, T., Vila-Caballer, M., Liu, J., Schiffhauer, S., & Finkielstein, C. V. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0994 · Cited by 74
Hinoi, E., Ueshima, T., Hojo, H., Takarada‐Iemata, M., Takarada, T., & Yoneda, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512362200 · Cited by 71
Clock genes and metabolic disease
Marcheva, B., Ramsey, K. M., Affinati, A. H., & Bass, J. T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00698.2009 · Cited by 73
Brain-muscle communication prevents muscle aging by maintaining daily physiology
Kumar, A., Vaca-Dempere, M., Mortimer, T., Deryagin, O., Smith, J. G., Petrus, P., Koronowski, K. B., Greco, C. M., Segalés, J., Andrés, E., et al. (2024) · Science · doi:10.1126/science.adj8533 · Cited by 72
CIRCADIAN RHYTHMICITY IN MURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS
Otway, D. T., Frost, G. S., & Johnston, J. D. (2009) · Chronobiology International · doi:10.3109/07420520903412368 · Cited by 71
Physiological links of circadian clock and biological clock of aging
Liu, F., & Chang, H.-C. (2017) · Protein & Cell · doi:10.1007/s13238-016-0366-2 · Cited by 69
Clock genes, pancreatic function, and diabetes
Vieira, E. C., Burris, T. P., & Quesada, I. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.10.007 · Cited by 72
Wu, X., Yu, G., Parks, H., Hebert, T., Goh, B. C. K., Dietrich, M. A., Pelled, G., Izadpanah, R., Gazit, D., Bunnell, B. A., et al. (2008) · Bone · doi:10.1016/j.bone.2007.12.226 · Cited by 68
Haupt, S., Eckstein, M. L., Wolf, A., Zimmer, R. T., Wachsmuth, N. B., & Moser, O. (2021) · Biomolecules · doi:10.3390/biom11040516 · Cited by 75
Induction of Circadian Gene Expression in Human Subcutaneous Adipose‐derived Stem Cells
Wu, X., Zvonic, S., Floyd, Z. E., Kilroy, G. E., Goh, B. C. K., Hernandez, T. L., Eckel, R. H., Mynatt, R. L., & Gimble, J. M. (2007) · Obesity · doi:10.1038/oby.2007.308 · Cited by 67
Pinealectomy interferes with the circadian clock genes expression in white adipose tissue
de Farias, T. D. S. M., de Oliveira, A. C., Andreotti, S., do Amaral, F. G., Chimin, P., de Proença, A. R. A., Torres‐Leal, F. L., Sertié, R. A. L., Campaña, A. B., Lopes, A. B., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12211 · Cited by 64
Chronopharmacological strategies focused on chrono-drug discovery
Ohdo, S., Koyanagi, S., & Matsunaga, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.018 · Cited by 65
The Role of Mammalian Circadian Proteins in Normal Physiology and Genotoxic Stress Responses
Kondratov, R. V., Gorbacheva, V., & Antoch, M. P. (2007) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)78005-x · Cited by 64
Yoshizaki, T., Tada, Y., Hida, A., Sunami, A., Yokoyama, Y., Yasuda, J., Nakai, A., Togo, F., & Kawano, Y. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2702-z · Cited by 65
Nuclear Receptors Linking Circadian Rhythms and Cardiometabolic Control
Duez, H., & Staels, B. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209098 · Cited by 67
Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice
Yoshida, C., Shikata, N., Seki, S., Koyama, N., & Noguchi, Y. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-78 · Cited by 68
Annual Life History–Dependent Gene Expression in the Hypothalamus and Liver of a Migratory Songbird
Trivedi, A. K., Kumar, J., Rani, S., & Kumar, V. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414549766 · Cited by 64
Kimiwada, T., Sakurai, M., Ohashi, H., Aoki, S., Tominaga, T., & Wada, K. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.005 · Cited by 64
Plasminogen Activator Inhibitor-1 and the Circadian Clock in Metabolic Disorders
Oishi, K. (2009) · Clinical and Experimental Hypertension · doi:10.1080/10641960902822468 · Cited by 61
Non‐alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity
Mazzoccoli, G., Vinciguerra, M., Oben, J. A., Tarquini, R., & Cosmo, S. D. (2014) · Liver International · doi:10.1111/liv.12534 · Cited by 66
Circadian Rhythms and Obesity in Mammals
Froy, O. (2012) · ISRN Obesity · doi:10.5402/2012/437198 · Cited by 66
Adipocytes and the Regulation of Bone Remodeling: A Balancing Act
NUTTALL, M. E., Shah, F. S., Singh, V., Thomas‐Porch, C., Frazier, T. P., & Gimble, J. M. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9807-6 · Cited by 61
Ullah, K., Chen, S., Lü, J., Wang, X., Liu, Q. L., Zhang, Y., Long, Y., Hu, Z., & Xu, G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011280 · Cited by 61
Nayak, N., & Mishra, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119758 · Cited by 60
Laermans, J., Vancleef, L., Tack, J. F., & Depoortere, I. (2015) · Scientific Reports · doi:10.1038/srep16748 · Cited by 60
Clock represses preadipocytes adipogenesis via GILZ
Zhu, Z., Xu, L., Cai, T., Yuan, G., Sun, N., Lü, C., & Qian, R. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26420 · Cited by 59
Asthma: Chronopharmacotherapy and the molecular clock
Burioka, N., Fukuoka, Y., Koyanagi, S., Miyata, M., Takata, M., Chikumi, H., Takane, H., Watanabe, M., Endo, M., Sako, T., et al. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.012 · Cited by 59
Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence
Zhang, W., Xiong, Y., Tao, R., Panayi, A. C., Mi, B., & Liu, G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.915139 · Cited by 61
Sukumaran, S., Xue, B., Jusko, W. J., DuBois, D. C., & Almon, R. R. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00106.2010 · Cited by 61
Circadian Rhythms and the Regulation of Metabolic Tissue Function and Energy Homeostasis
Zvonic, S., Floyd, Z. E., Mynatt, R. L., & Gimble, J. M. (2007) · Obesity · doi:10.1038/oby.2007.544 · Cited by 57
Mouralidarane, A., Soeda, J., Sugden, D., Bocianowska‐Zbrog, A., Carter, R. M., Ray, S., Saraswati, R., Cordero, P., Novelli, M. R., Fusai, G., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.85 · Cited by 55
Boucher, H., Vanneaux, V., Domet, T., Parouchev, A., & Larghero, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146674 · Cited by 57
Circadian rhythms and pancreas physiology: A review
Chan, K., Wong, F. S., & Pearson, J. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.920261 · Cited by 65
Li, T., Eheim, A. L., Klein, S., Uschner, F. E., Smith, A. C., Brandon‐Warner, E., Ghosh, S., Bonkovsky, H. L., Trebicka, J., & Schrum, L. W. (2014) · Hepatology · doi:10.1002/hep.27049 · Cited by 55
Matsumoto, E., Ishihara, A., Tamai, S., Nemoto, A., Iwase, K., Hiwasa, T., Shibata, S., & Takiguchi, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.089391 · Cited by 53
Ohoka, N., Kato, S., Takahashi, Y., Hayashi, H., & Sato, R. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0277 · Cited by 55
Circadian Rhythms in Adipose Tissue Physiology
Kiehn, J., Tsang, A. H. K., Heyde, I., Leinweber, B., Kolbe, I., Leliavski, A., & Oster, H. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160017 · Cited by 64
Guo, R., Zhao, B., Wang, Y., Wu, D., Wang, Y., Yu, Y., Yan, Y., Zhang, W., Liu, Z., & Liu, X. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02147 · Cited by 57
Nakazato, R., Takarada, T., Yamamoto, T. M., Hotta, S., Hinoi, E., & Yoneda, Y. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11069fp · Cited by 55
Vu, J. P., Larauche, M. H., Flores, M., Luong, L., Norris, J., Oh, S., Liang, L.-J. F., Waschek, J. A., Pisegna, J. R., & Germano, P. M. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0556-z · Cited by 55
Contributions of White and Brown Adipose Tissues to the Circadian Regulation of Energy Metabolism
Heyde, I., Begemann, K., & Oster, H. (2021) · Endocrinology · doi:10.1210/endocr/bqab009 · Cited by 60
Molecular Basis of Chronopharmaceutics
Ohdo, S., Koyanagi, S., Matsunaga, N., & Hamdan, A. M. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22656 · Cited by 51
Circadian clocks, diets and aging
Chaudhari, A., Gupta, R., Makwana, K., & Kondratov, R. V. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160006 · Cited by 53
Chronopharmaceutics: Pharmaceutics Focused on Biological Rhythm
Ohdo, S. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.159 · Cited by 51
Ikeda, E., Matsunaga, N., Kakimoto, K., Hamamura, K., Hayashi, A., Koyanagi, S., & Ohdo, S. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.083535 · Cited by 50
Metadata
- Authors
- Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M.
- Affiliations
- Nihon University (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-08-10
- Volume
- 102
- Issue
- 34
- Pages
- 12071-12076
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1189312
- OpenAlex
- W2047902467
- Cited by
- 536
- References
- 39
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 22 · 2021: 28 · 2020: 19 · 2019: 16 · 2018: 22 · 2017: 24 · 2016: 19 · 2015: 24 · 2014: 33 · 2013: 40 · 2012: 32
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nihon University
- Ono Medical Research Foundation
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- Bmal1, circadian clock, adipogenesis, lipogenesis, lipid metabolism, 3T3-L1 cells, adipose tissue, circadian rhythm, transcription factors, adipocytes, lipid droplets, gene knockdown, adenoviral gene transfer
- MeSH terms
- Adenoviridae, Adipose Tissue, Animals, Brain, Circadian Rhythm, Gene Expression Regulation, Genetic Vectors, Male, Mice, Inbred C57BL, Immunoblotting, 3T3 Cells, DNA Primers, Gene Transfer Techniques, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference, Chromatin Immunoprecipitation, Adipogenesis, Lipid Metabolism, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, ARNTL Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review