The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth
Open accessAbstract
The inability of CNS axons to regenerate after traumatic spinal cord injury is due, in part, to the inhibitory effects of myelin. The three major previously identified constituents of this activity (Nogo, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein) were isolated based on their potent inhibition of axon outgrowth in vitro . All three myelin components transduce their inhibitory signals through the same Nogo receptor/p75 neurotrophin receptor/LINGO-1 (NgR1/p75/LINGO-1) complex. In this study, we considered that molecules known to act as repellants in vertebrate embryonic axonal pathfinding may also inhibit regeneration. In mice, ephrin-B3 functions during development as a midline repellant for axons of the corticospinal tract. We therefore investigated whether this repellant was expressed in the adult spinal cord and retained inhibitory activity. We demonstrate that ephrin-B3 is expressed in postnatal myelinating oligodendrocytes and, by using primary CNS neurons, show that ephrin-B3 accounts for an inhibitory activity equivalent to that of the other three myelin-based inhibitors, acting through p75, combined. Our data describe a known vertebrate axon guidance molecule as a myelin-based inhibitor of neurite outgrowth.
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Cites
Molecular Mechanisms of Axon Guidance
Dickson, B. J. (2002) · Science · doi:10.1126/science.1072165 · Cited by 1,425
MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413
Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
Fournier, A. E., GrandPre, T., & Strittmatter, S. M. (2001) · Nature · doi:10.1038/35053072 · Cited by 1,080
Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,073
Self-citationLee, K.-F., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90286-l · Cited by 956
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
Wang, K. C., Koprivica, V., Kim, J. A., Sivasankaran, R., Guo, Y., Neve, R. L., & He, Z. (2002) · Nature · doi:10.1038/nature00867 · Cited by 955
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J., Levesque, M., Allaire, N., Perrin, S., Sands, B., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1188 · Cited by 826
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
Wang, K. C., Kim, J. A., Sivasankaran, R., Segal, R., & He, Z. (2002) · Nature · doi:10.1038/nature01176 · Cited by 819
Rho Signaling Pathway Targeted to Promote Spinal Cord Repair
Dergham, P., Ellezam, B., Essagian, C., Avedissian, H., Lubell, W. D., & McKerracher, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06570.2002 · Cited by 726
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Cited by
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595
Why is Wallerian degeneration in the CNS so slow?
Vargas, M. E., & Barres, B. A. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094354 · Cited by 510
The role of extracellular matrix in CNS regeneration
Busch, S. A., & Silver, J. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.004 · Cited by 468
Guidance Molecules in Axon Regeneration
Giger, R. J., Hollis, E. R., & Tuszynski, M. H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001867 · Cited by 346
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Metadata
- Authors
- Benson, M. D., Romero, M. I., Lush, M. E., Lu, Q. R., Henkemeyer, M., & Parada, L. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-07-14
- Volume
- 102
- Issue
- 30
- Pages
- 10694-10699
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072821348
- Cited by
- 305
- References
- 42
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Benson, M. D., Romero, M. I., Lush, M. E., Lu, Q. R., Henkemeyer, M., & Parada, L. F. (2005). Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0504021102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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