The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
Open accessAbstract
The RNaseIII-containing enzyme Dicer is believed to be required for the processing of most, if not all, microRNAs (miRNAs) and for processing long dsRNA into small interfering RNAs. Because the complete loss of Dicer in both zebrafish and mice results in early embryonic lethality, it has been impossible to determine what role, if any, Dicer has in patterning later tissues in the developing vertebrate embryo. To bypass the early requirement of Dicer in development, we have created a conditional allele of this gene in mice. Using transgenes to drive Cre expression in discrete regions of the limb mesoderm, we find that removal of Dicer results in the loss of processed miRNAs. Phenotypically, developmental delays, in part due to massive cell death as well as disregulation of specific gene expression, lead to the formation of a much smaller limb. Thus, Dicer is required for the formation of normal mouse limbs. Strikingly, however, we did not detect defects in basic patterning or in tissue-specific differentiation of Dicer -deficient limb buds.
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MicroRNAs Regulate Brain Morphogenesis in Zebrafish
Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., Hammond, S. M., Bartel, D. P., & Schier, A. F. (2005) · Science · doi:10.1126/science.1109020 · Cited by 1,315
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The Diverse Functions of MicroRNAs in Animal Development and Disease
Kloosterman, W. P., & Plasterk, R. H. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.009 · Cited by 2,082
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
Metadata
- Authors
- Harfe, B. D., McManus, M. T., Mansfield, J. H., Hornstein, E., & Tabin, C. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-07-22
- Volume
- 102
- Issue
- 31
- Pages
- 10898-10903
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094786733
- Cited by
- 646
- References
- 7
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. https://app.cochat.ai/papers/10.1073/pnas.0504834102
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- Harfe, B. D., McManus, M. T., Mansfield, J. H., Hornstein, E., & Tabin, C. J. (2005). The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0504834102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
