The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
DCDC2 is associated with reading disability and modulates neuronal development in the brain
Open accessAbstract
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2 . Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration. The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,525
Developmental dyslexia: Four consecutive patients with cortical anomalies
Galaburda, A. M., Sherman, G. F., Rosen, G. D., Aboitiz, F., & Geschwind, N. (1985) · Annals of Neurology · doi:10.1002/ana.410180210 · Cited by 1,313
Current Protocols in Bioinformatics
(2002) · John Wiley & Sons, Inc. eBooks · doi:10.1002/0471250953 · Cited by 1,207
Sobel, E. M., & Lange, K. L. (1996) · PubMed Central · Cited by 1,176
The neural code for written words: a proposal
DEHAENE, S., COHEN, L., SIGMAN, M., & VINCKIER, F. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.05.004 · Cited by 1,147
Dean, F. B., Nelson, J. R., Giesler, T. L., & Lasken, R. S. (2001) · Genome Research · doi:10.1101/gr.180501 · Cited by 1,067
Dyslexia (Specific Reading Disability)
Shaywitz, S. E., & Shaywitz, B. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.043 · Cited by 1,005
Self-citationDisruption of posterior brain systems for reading in children with developmental dyslexia
Shaywitz, B. A., Shaywitz, S. E., Pugh, K. R., Mencl, W. E., Fulbright, R. K., Skudlarski, P., Constable, R. T., Marchione, K. E., Fletcher, J. M., Lyon, G. R., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01365-3 · Cited by 993
Self-citationFunctional disruption in the organization of the brain for reading in dyslexia
Shaywitz, S. E., Shaywitz, B. A., Pugh, K. R., Fulbright, R. K., Constable, R. T., Mencl, W. E., Shankweiler, D. P., Liberman, A. M., Skudlarski, P., Fletcher, J. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2636 · Cited by 872
Self-citationGOLD—Graphical Overview of Linkage Disequilibrium
Abecasis, G. R., & Cookson, W. O. C. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.2.182 · Cited by 773
Cited by
Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04362-x · Cited by 686
The Education of Dyslexic Children from Childhood to Young Adulthood
Shaywitz, S. E., Morris, R., & Shaywitz, B. A. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093633 · Cited by 383
Self-citationDyscalculia and dyslexia in adults: cognitive bases of comorbidity
Wilson, A. J., Andrewes, S. G., Struthers, H., Rowe, V. M., Bogdanovic, R., & Waldie, K. E. (2015) · Learning and Individual Differences · doi:10.1016/j.lindif.2014.11.017 · Cited by 144
Rice, M. L., Smith, S. D., & Gayán, J. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9031-x · Cited by 122
Self-citationA theoretical molecular network for dyslexia: integrating available genetic findings.
Poelmans, G., Buitelaar, J. K., Pauls, D. L., & Franke, B. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.105 · Cited by 119
Metadata
- Authors
- Meng, H., Smith, S. D., Hager, K., Held, M., Liu, J., Olson, R. K., Pennington, B. F., DeFries, J. C., Gelernter, J., O'Reilly-Pol, T., Somlo, S., Skudlarski, P., Shaywitz, S. E., Shaywitz, B. A., Marchione, K., Wang, Y., Paramasivam, M., LoTurco, J. J., Page, G. P., & Gruen, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-11-08
- Volume
- 102
- Issue
- 47
- Pages
- 17053-17058
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105632506
- Cited by
- 386
- References
- 35
- FWCI
- 44.48
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DCDC2 is associated with reading disability and modulates neuronal development in the brain. https://app.cochat.ai/papers/10.1073/pnas.0508591102
- The paper
- Meng, H., Smith, S. D., Hager, K., Held, M., Liu, J., Olson, R. K., Pennington, B. F., DeFries, J. C., Gelernter, J., O'Reilly-Pol, T., Somlo, S., Skudlarski, P., Shaywitz, S. E., Shaywitz, B. A., Marchione, K., Wang, Y., Paramasivam, M., LoTurco, J. J., Page, G. P., & Gruen, J. R. (2005). DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0508591102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
