The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The consensus mechanics of cultured mammalian cells
Open accessAbstract
Although understanding cells' responses to mechanical stimuli is seen as increasingly important for understanding cell biology, how to best measure, interpret, and model cells' mechanical properties remains unclear. We determine the frequency-dependent shear modulus of cultured mammalian cells by using four different methods, both unique and well established. This approach clarifies the effects of cytoskeletal heterogeneity, ATP-dependent processes, and cell regional variations on the interpretation of such measurements. Our results clearly indicate two qualitatively similar, but distinct, mechanical responses, corresponding to the cortical and intracellular networks, each having an unusual, weak power-law form at low frequency. The two frequency-dependent responses we observe are remarkably similar to those reported for a variety of cultured mammalian cells measured with different techniques, suggesting it is a useful consensus description. Finally, we discuss possible physical explanations for the observed mechanical response.
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Pajerowski, J. D., Dahl, K. N., Zhong, F. L., Sammak, P. J., & Discher, D. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702576104 · Cited by 833
Modeling semiflexible polymer networks
Broedersz, C. P., & MacKintosh, F. C. (2014) · Reviews of Modern Physics · doi:10.1103/revmodphys.86.995 · Cited by 733
Universal physical responses to stretch in the living cell
Trepat, X., Deng, L., An, S. S., Navajas, D., Tschumperlin, D. J., Gerthoffer, W. T., Butler, J. P., & Fredberg, J. J. (2007) · Nature · doi:10.1038/nature05824 · Cited by 699
The cytoplasm of living cells behaves as a poroelastic material
Moeendarbary, E., Valon, L., Fritzsche, M., Harris, A. R., Moulding, D. A., Thrasher, A. J., Stride, E., Mahadevan, L., & Charras, G. T. (2013) · Nature Materials · doi:10.1038/nmat3517 · Cited by 686
Cell Mechanics: Integrating Cell Responses to Mechanical Stimuli
Janmey, P. A., & McCulloch, C. A. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.151927 · Cited by 630
Metadata
- Authors
- Hoffman, B. D., Massiera, G., Van Citters, K. M., & Crocker, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-07-05
- Volume
- 103
- Issue
- 27
- Pages
- 10259-10264
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2112550344
- Cited by
- 403
- References
- 35
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hoffman, B. D., Massiera, G., Van Citters, K. M., & Crocker, J. C. (2006). The consensus mechanics of cultured mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0510348103
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