The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1
Open accessAbstract
Human bone marrow expresses a pseudogene that encodes an antimicrobial peptide homologous to rhesus monkey circular minidefensins (θ-defensins). We prepared the putative ancestral human peptide by solid-phase synthesis and named it “retrocyclin.” Retrocyclin did not cause direct inactivation of HIV-1, and its modest antibacterial properties resembled those of its rhesus homologs. Nevertheless, retrocyclin had a remarkable ability to inhibit proviral DNA formation and to protect immortalized and primary human CD4 + lymphocytes from in vitro infection by both T-tropic and M-tropic strains of HIV-1. Confocal fluorescent microscopy studies performed with BODIPY-FL-labeled RC-101, a close analog of retrocyclin, showed that the peptide formed patch-like aggregates on the surface of CD4 + cells. These findings suggest that retrocyclin interferes with an early stage of HIV-1 infection and that retrocyclin-like agents might be useful topical agents to prevent sexually acquired HIV-1 infections.
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Cites
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
Wong, J. K., Hezareh, M., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Spina, C. A., & Richman, D. D. (1997) · Science · doi:10.1126/science.278.5341.1291 · Cited by 2,186
Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity
Cole, S. W., Naliboff, B. D., Kemeny, M. E., Griswold, M. P., Fahey, J. L., & Zack, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221134198 · Cited by 129
Self-citation
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
Anti-microbial peptides: from invertebrates to vertebrates
Bulet, P., Stöcklin, R., & Menin, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0124.x · Cited by 1,107
Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Defensins in innate antiviral immunity
Klotman, M. E., & Chang, T. L. (2006) · Nature Reviews Immunology · doi:10.1038/nri1860 · Cited by 471
Metadata
- Authors
- Cole, A. M., Hong, T., Boo, L. M., Nguyen, T., Zhao, C., Bristol, G., Zack, J. A., Waring, A. J., Yang, O. O., & Lehrer, R. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-19
- Volume
- 99
- Issue
- 4
- Pages
- 1813-1818
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2101382753
- Cited by
- 298
- References
- 2
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. https://app.cochat.ai/papers/10.1073/pnas.052706399
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- Cole, A. M., Hong, T., Boo, L. M., Nguyen, T., Zhao, C., Bristol, G., Zack, J. A., Waring, A. J., Yang, O. O., & Lehrer, R. I. (2002). Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.052706399
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