The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens
Abstract
The concentration of GABA increases rapidly in wounded plant tissues, but the implication of this GABA pulse for plant–bacteria interactions is not known. Here we reveal that GABA stimulated the inactivation of the N -(3-oxooctanoyl)homoserine lactone (OC8-HSL) quorum-sensing signal (or “quormone”) by the Agrobacterium lactonase AttM. GABA induced the expression of the attKLM operon, which was correlated to a decrease in OC8-HSL concentration in Agrobacterium tumefaciens cultures. The Agrobacterium GABA transporter Bra was required for this GABA-signaling pathway. Furthermore, transgenic tobacco plants with elevated GABA levels were less sensitive to A. tumefaciens C58 infection than were wild-type plants. These findings indicate that plant GABA may modulate quorum sensing in A. tumefaciens , thereby affecting its virulence on plants. Whereas GABA is an essential cell-to-cell signal in eukaryotes, here we provide evidence of GABA acting as a signal between eukaryotes and pathogenic bacteria. The GABA signal represents a potential target for the development of a strategy to control the virulence of bacterial pathogens.
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Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,914
GABA in plants: just a metabolite?
Bouché, N., & Fromm, H. (2004) · Trends in Plant Science · doi:10.1016/j.tplants.2004.01.006 · Cited by 1,154
Stachel, S. E., Messens, E., MONTAGU, M. V., & Zambryski, P. (1985) · Nature · doi:10.1038/318624a0 · Cited by 1,022
Metabolism and functions of gamma-aminobutyric acid
Shelp, B. (1999) · Trends in Plant Science · doi:10.1016/s1360-1385(99)01486-7 · Cited by 965
Self-citationThe Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58
Wood, D. W., Setubal, J. C., Kaul, R., Monks, D. E., Kitajima, J. P., Okura, V. K., Zhou, Y., Chen, L., Wood, G. E., Almeida, N. F., et al. (2001) · Science · doi:10.1126/science.1066804 · Cited by 789
Agrobacterium tumefaciens DNA and PS8 Bacteriophage DNA Not Detected in Crown Gall Tumors
Chilton, M.-D., Currier, T. C., Farrand, S. K., Bendich, A. J., Gordon, M. P., & Nester, E. W. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3672 · Cited by 663
Cha, C., Gao, P., Chen, Y.-C., Shaw, P. D., & Farrand, S. K. (1998) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi.1998.11.11.1119 · Cited by 618
Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals
Mathesius, U., Mulders, S., Gao, M., Teplitski, M., Caetano-Anollés, G., Rolfe, B. G., & Bauer, W. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262672599 · Cited by 532
Pollen Tube Growth and Guidance Is Regulated by POP2, an Arabidopsis Gene that Controls GABA Levels
Palanivelu, R., Brass, L., Edlund, A. F., & Preuss, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00479-3 · Cited by 529
Conjugation factor of Agrobacterium tumefaciens regulates Ti plasmid transfer by autoinduction
Piper, K. R., von Bodman, S. B., & Farrand, S. K. (1993) · Nature · doi:10.1038/362448a0 · Cited by 509
Cited by
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Inter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761
Badri, D. V., Chaparro, J. M., Zhang, R., Shen, Q., & Vivanco, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.433300 · Cited by 578
Gamma-aminobutyric acid as a bioactive compound in foods: A review
Diana, M., Quílez, J., & Rafecas, M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.004 · Cited by 473
Role of glutamate metabolism in bacterial responses towards acid and other stresses
Feehily, C., & Karatzas, K. A. G. (2013) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05434.x · Cited by 455
Metadata
- Authors
- Chevrot, R., Rosen, R., Haudecoeur, E., Cirou, A., Shelp, B. J., Ron, E., & Faure, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-05-09
- Volume
- 103
- Issue
- 19
- Pages
- 7460-7464
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020026716
- Cited by
- 259
- References
- 27
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chevrot, R., Rosen, R., Haudecoeur, E., Cirou, A., Shelp, B. J., Ron, E., & Faure, D. (2006). GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0600313103
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