Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

Emery, Ben; Cate, Holly S.; Marriott, Mark; Merson, Tobias; Binder, Michele D.; Snell, Cameron; Soo, Pik Ying; Murray, Simon; Croker, Ben; Zhang, Jian-Guo; Alexander, Warren S.; Cooper, Helen; Butzkueven, Helmut; Kilpatrick, Trevor J.

doi:10.1073/pnas.0602574103

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

Enhancement of oligodendrocyte survival through activation of leukemia inhibitory factor receptor (LIFR) signaling is a candidate therapeutic strategy for demyelinating disease. However, in other cell types, LIFR signaling is under tight negative regulation by the intracellular protein suppressor…