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Absence of the lactase-persistence-associated allele in early Neolithic Europeans
Open accessAbstract
Lactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last 20,000 years. This trait is likely to have conferred a selective advantage in individuals who consume appreciable amounts of unfermented milk. Some have argued for the “culture-historical hypothesis,” whereby LP alleles were rare until the advent of dairying early in the Neolithic but then rose rapidly in frequency under natural selection. Others favor the “reverse cause hypothesis,” whereby dairying was adopted in populations with preadaptive high LP allele frequencies. Analysis based on the conservation of lactase gene haplotypes indicates a recent origin and high selection coefficients for LP, although it has not been possible to say whether early Neolithic European populations were lactase persistent at appreciable frequencies. We developed a stepwise strategy for obtaining reliable nuclear ancient DNA from ancient skeletons, based on ( i ) the selection of skeletons from archaeological sites that showed excellent biomolecular preservation, ( ii ) obtaining highly reproducible human mitochondrial DNA sequences, and ( iii ) reliable short tandem repeat (STR) genotypes from the same specimens. By applying this experimental strategy, we have obtained high-confidence LP-associated genotypes from eight Neolithic and one Mesolithic human remains, using a range of strict criteria for ancient DNA work. We did not observe the allele most commonly associated with LP in Europeans, thus providing evidence for the culture-historical hypothesis, and indicating that LP was rare in early European farmers.
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Cites
Convergent adaptation of human lactase persistence in Africa and Europe
Tishkoff, S. A., Reed, F. A., Ranciaro, A., Voight, B. F., Babbitt, C. C., Silverman, J. S., Powell, K., Mortensen, H. M., Hirbo, J. B., Osman, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1946 · Cited by 1,615
Hofreiter, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.23.4793 · Cited by 684
Mutations arising in the wave front of an expanding population
Edmonds, C. A., Lillie, A. S., & Cavalli-Sforza, L. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308064100 · Cited by 429
The effect of the Neolithic expansion on European molecular diversity
Currat, M., & Excoffier, L. (2005) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2004.2999 · Cited by 210
Did the first farmers of central and eastern Europe produce dairy foods?
Craig, O. E., Chapman, J., Heron, C., Willis, L. H., Bartosiewicz, L., Taylor, G., Whittle, A., & Collins, M. (2005) · Antiquity · doi:10.1017/s0003598x00115017 · Cited by 188
Comment on "Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites"
Ammerman, A. J., Pinhasi, R., & Bánffy, E. (2006) · Science · doi:10.1126/science.1123936 · Cited by 56
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Mathieson, I., Lazaridis, I., Rohland, N., Mallick, S., Patterson, N., Roodenberg, S. A., Harney, E., Stewardson, K., Fernandes, D., Novak, M., et al. (2015) · Nature · doi:10.1038/nature16152 · Cited by 1,515
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Olalde, I., Brace, S., Allentoft, M. E., Armit, I., Kristiansen, K., Booth, T., Rohland, N., Mallick, S., Szécsényi-Nagy, A., Mittnik, A., et al. (2018) · Nature · doi:10.1038/nature25738 · Cited by 765
Self-citationGenome flux and stasis in a five millennium transect of European prehistory
Gamba, C., Jones, E. R., Teasdale, M. D., McLaughlin, R. L., Gonzalez-Fortes, G., Mattiangeli, V., Domboróczki, L., Kővári, I., Pap, I., Anders, A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6257 · Cited by 667
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Itan, Y., Powell, A., Beaumont, M. A., Burger, J., & Thomas, M. G. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000491 · Cited by 569
“Allelic age estimates are also consistent with the results of a recent ancient DNA study [27] which showed that the 213,910*T allele was rare or absent among early farmers from Central and Eastern Europe.”
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Keller, A., Graefen, A., Ball, M., Matzas, M., Boisguerin, V., Maixner, F., Leidinger, P., Backes, C., Khairat, R., Forster, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms1701 · Cited by 437
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Laland, K. N., & O’Brien, M. J. (2011) · Biological Theory · doi:10.1007/s13752-012-0026-6 · Cited by 312
Darwin in Mind: New Opportunities for Evolutionary Psychology
Bolhuis, J. J., Brown, G. R., Richardson, R. C., & Laland, K. N. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001109 · Cited by 242
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Skoglund, P., & Mathieson, I. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021749 · Cited by 246
Elwood, P. C., Givens, D. I., Beswick, A. D., Fehily, A. M., Pickering, J. E., & Gallacher, J. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719750 · Cited by 206
Direct evidence of milk consumption from ancient human dental calculus
Warinner, C., Hendy, J., Speller, C., Cappellini, E., Fischer, R., Trachsel, C., Arneborg, J., Lynnerup, N., Craig, O. E., Swallow, D. M., et al. (2014) · Scientific Reports · doi:10.1038/srep07104 · Cited by 216
Distinguishing between selective sweeps from standing variation and from a de novo mutation
Peter, B. M., Huerta-Sanchez, E., & Nielsen, R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003011 · Cited by 193
Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers
Hendy, J., Colonese, A. C., Franz, I., Fernandes, R., Fischer, R., Orton, D., Lucquin, A., Spindler, L., Anvari, J., Stroud, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06335-6 · Cited by 159
The behavioral ecology of cultural psychological variation.
Sng, O., Neuberg, S. L., Varnum, M. E. W., & Kenrick, D. T. (2018) · Psychological Review · doi:10.1037/rev0000104 · Cited by 157
Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a
Underhill, P. A., Myres, N. M., Rootsi, S., Metspalu, M., Zhivotovsky, L. A., King, R. J., Lin, A. A., Chow, C.-E. T., Semino, O., Battaglia, V., et al. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.194 · Cited by 151
Oelze, V. M., Siebert, A., Nicklisch, N., Meller, H., Dresely, V., & Alt, K. W. (2011) · Journal of Archaeological Science · doi:10.1016/j.jas.2010.08.027 · Cited by 115
Burger, J., Link, V., Blöcher, J., Schulz, A., Sell, C., Pochon, Z., Diekmann, Y., Žegarac, A., Hofmanová, Z., Winkelbach, L., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.033 · Cited by 108
Self-citationHuman evolution: a tale from ancient genomes
Llamas, B., Willerslev, E., & Orlando, L. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0484 · Cited by 100
Ancient proteins provide evidence of dairy consumption in eastern Africa
Bleasdale, M., Richter, K. K., Janzen, A., Brown, S., Scott, A., Zech, J., Wilkin, S., Wang, K., Schiffels, S., Desideri, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20682-3 · Cited by 87
Niche construction, co-evolution and biodiversity
Laland, K. N., & Boogert, N. J. (2010) · Ecological Economics · doi:10.1016/j.ecolecon.2008.11.014 · Cited by 80
New insights into Neolithic milk consumption through proteomic analysis of dental calculus
Charlton, S., Ramsøe, A., Collins, M., Craig, O. E., Fischer, R., Alexander, M., & Speller, C. F. (2019) · Archaeological and Anthropological Sciences · doi:10.1007/s12520-019-00911-7 · Cited by 69
Fatty acid specific δ13C values reveal earliest Mediterranean cheese production 7,200 years ago
McClure, S. B., Magill, C., Podrug, E., Moore, A. M. T., Harper, T. K., Culleton, B. J., Kennett, D. J., & Freeman, K. H. (2018) · PLOS ONE · doi:10.1371/journal.pone.0202807 · Cited by 66
The role of food storage in human niche construction: An example from Neolithic Europe
O'Brien, M. J., & Bentley, R. A. (2015) · Environmental Archaeology · doi:10.1179/1749631414y.0000000053 · Cited by 23
Metadata
- Authors
- Burger, J., Kirchner, M., Bramanti, B., Haak, W., & Thomas, M. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-03-06
- Volume
- 104
- Issue
- 10
- Pages
- 3736-3741
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2135959118
- Cited by
- 448
- References
- 6
- FWCI
- 18.25
- Type
- journal article
- Language
- en
- Open access
- green
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