Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity

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Shah, N., Singh, R., Sarangi, U., Saxena, N., Chaudhary, A., Kaur, G., Kaul, S. C., & Wadhwa, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120554 · Cited by 73 · see citing works

Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells

Dar, N. J., Bhat, J. A., Satti, N. K., Sharma, P. R., Hamid, A., & Ahmad, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0044-7 · Cited by 69 · see citing works

Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats

Cheruku, S. P., Ramalingayya, G. V., Chamallamudi, M. R., Biswas, S., Nandakumar, K., Nampoothiri, M., Gourishetti, K., & Kumar, N. (2017) · Cytotechnology · doi:10.1007/s10616-017-0138-8 · Cited by 61 · see citing works

Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study

Kumar, G., & Patnaik, R. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.04.034 · Cited by 59 · see citing works

Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis

Dutta, K., Patel, P., & Julien, J.-P. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.008 · Cited by 56 · see citing works

Intermittent Fasting Dietary Restriction Regimen Negatively Influences Reproduction in Young Rats: A Study of Hypothalamo-Hypophysial-Gonadal Axis

Sushil Kumar, K., & Kaur, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052416 · Cited by 57 · see citing works

Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review

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Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity

Kumar, P., Singh, R. P., Nazmi, A., Lakhanpal, D., Kataria, H., & Kaur, G. (2014) · BioMed Research International · doi:10.1155/2014/182029 · Cited by 53 · see citing works

Biotechnological interventions inWithania somnifera(L.) Dunal

Singh, P., Guleri, R., Singh, V., Kaur, G., Kataria, H., Singh, B. B., Kaur, G., Kaul, S. C., Wadhwa, R., & Pati, P. K. (2015) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2015.1020467 · Cited by 51 · see citing works

In vitro models for neurotoxicology research

Barbosa, D. J., Capela, J. P., Bastos, M. D. L., & Carvalho, F. D. (2015) · Toxicology Research · doi:10.1039/c4tx00043a · Cited by 49 · see citing works

Withania somnifera Improves Ischemic Stroke Outcomes by Attenuating PARP1-AIF-Mediated Caspase-Independent Apoptosis

Raghavan, A., & Shah, Z. A. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8907-2 · Cited by 47 · see citing works

Withania somnifera (L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate

Bhat, J. A., Akther, T., Najar, R. A., Rasool, F., & Hamid, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1029123 · Cited by 51 · see citing works

Withania somnifera Water Extract as a Potential Candidate for Differentiation Based Therapy of Human Neuroblastomas

Kataria, H., Wadhwa, R., Kaul, S. C., & Kaur, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055316 · Cited by 45 · see citing works

Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts

Kaul, S. C., Ishida, Y., Tamura, K., Wada, T., Iitsuka, T., Garg, S., Kim, M., Gao, R., Nakai, S., Okamoto, Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166945 · Cited by 45 · see citing works

Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts

Wadhwa, R., Konar, A., & Kaul, S. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.001 · Cited by 43 · see citing works

Withania somnifera Leaf Extract Ameliorates Benzo[a]pyrene-Induced Behavioral and Neuromorphological Alterations by Improving Brain Antioxidant Status in Zebrafish ( Danio rerio )

Mohanty, R., Das, S. K., Singh, N. R., & Patri, M. (2016) · Zebrafish · doi:10.1089/zeb.2015.1215 · Cited by 39 · see citing works

Inhibition of Gelatinases (MMP-2 and MMP-9) by Withania somnifera Phytochemicals Confers Neuroprotection in Stroke: An In Silico Analysis

Kumar, G., & Patnaik, R. (2017) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-017-0231-x · Cited by 35 · see citing works

Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke

Sood, A., Mehrotra, A., Dhawan, D. K., & Sandhir, R. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0234-2 · Cited by 35 · see citing works

Withania somnifera - a magic plant targeting multiple pathways in cancer related inflammation

Kumar, P., Sharma, R., & Garg, N. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154137 · Cited by 37 · see citing works

Ayurvedic Amalaki Rasayana and Rasa-Sindoor suppress neurodegeneration in fly models of Huntington's and Alzheimer's diseases

Dwivedi, V., Tripathi, B. K., Mutsuddi, M., & Lakhotia, S. C. (2013) · Cited by 32 · see citing works

Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke

Sood, A., Kumar, A., Dhawan, D., & Sandhir, R. (2015) · Cellular and molecular neurobiology · doi:10.1007/s10571-015-0305-4 · Cited by 29 · see citing works

Potential of Medicinal Plants as Neuroprotective and Therapeutic Properties Against Amyloid-β-Related Toxicity, and Glutamate-Induced Excitotoxicity in Human Neural Cells

Lobine, D., Sadeer, N., Jugreet, S., Suroowan, S., Keenoo, B. S., Imran, M., Venugopala, K. N., Ibrahim, F. M., Zengin, G., & Mahomoodally, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210412095251 · Cited by 32 · see citing works

Surfactin exhibits neuroprotective effects by inhibiting amyloid β-mediated microglial activation

Park, S. Y., Kim, J.-H., Lee, S. J., & Kim, Y. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.07.004 · Cited by 30 · see citing works

Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats

Khadrawy, Y. A., Elhadidy, M. E., Sawie, H. G., & Meguid, N. A. (2018) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.221139 · Cited by 29 · see citing works

Neuroimmunomodulatory properties of DPSCs in an in vitro model of Parkinson's disease

Gnanasegaran, N., Govindasamy, V., Mani, V., & Kasim, N. H. A. (2017) · IUBMB Life · doi:10.1002/iub.1655 · Cited by 28 · see citing works

Neuropharmacological Properties of Withania somnifera - Indian Ginseng: An Overview on Experimental Evidence with Emphasis on Clinical Trials and Patents

Yenisetti, S. C., Manjunath, M. J., & ., M. (2016) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889810666160615014106 · Cited by 29 · see citing works

Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review.

Afshari, A. R., Fanoudi, S., Rajabian, A., Sadeghnia, H. R., Mollazadeh, H., & Hosseini, A. (2020) · PubMed Central · doi:10.22038/ijbms.2020.43687.10259 · Cited by 24 · see citing works

Bacopa monnieri extracts prevent hydrogen peroxide-induced oxidative damage in a cellular model of neuroblastoma IMR32 cells

Bhatia, G., Dhuna, V., Dhuna, K., Kaur, M., & Singh, J. V. (2017) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(18)30017-7 · Cited by 21 · see citing works

An in silico guided identification of nAChR agonists from Withania somnifera

Remya, C., Dileep, K. V., Variayr, E. J., & Sadasivan, C. (2016) · Frontiers in Life Science · doi:10.1080/21553769.2016.1207569 · Cited by 19 · see citing works

Correction: Water Extract of Ashwagandha Leaves Has Anticancer Activity: Identification of an Active Component and Its Mechanism of Action

Wadhwa, R., Singh, R., Gao, R., Shah, N., Widodo, N., Nakamoto, T., Ishida, Y., Terao, K., & Kaul, S. C. (2013) · PLoS ONE · doi:10.1371/annotation/b7059f27-5970-4734-8601-9913adcce984 · Cited by 19 · see citing works

Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions

Sandhir, R., & Sood, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_18 · Cited by 18 · see citing works

Naringin ameliorates doxorubicin-induced neurotoxicity In vitro and cognitive dysfunction In vivo

Nandakumar, K., Ramalingayya, G. V., Nayak, P. G., Shenoy, R., Mallik, S., Gourishetti, K., Hussain, S. M., & Rao, C. M. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_364_17 · Cited by 16 · see citing works

β-Ionone derived apoptosis inducing endoperoxides; Discovery of potent leads for anticancer agents

Sharma, V., Chaudhry, A., Chashoo, G., Arora, R., Arora, S., Saxena, A. K., & Ishar, M. P. S. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.09.049 · Cited by 15 · see citing works

In Vitro Antioxidant Activity of Withania Somnifera Root

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Effects of standardized extract of Ferula gummosa root on glutamate-induced neurotoxicity

Sadeghnia, H. R., Rajabian, A., Ghorbani, A., Moradzadeh, M., & Hosseini, A. (2017) · Folia Neuropathologica · doi:10.5114/fn.2017.72399 · Cited by 12 · see citing works

Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits

Vittal, M., & Vinciguerra, M. (2025) · Biogerontology · doi:10.1007/s10522-025-10320-0 · Cited by 11 · see citing works

Organic manures and biostimulants fostered soil health and increased the harvest quality of the medicinal herb ashwagandha

Jat, R. S., Basak, B. B., & Gajbhiye, N. (2020) · Agronomy Journal · doi:10.1002/agj2.20457 · Cited by 11 · see citing works

Upregulation of CBS/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS/NO pathway

Wang, X., & Yang, H. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.06.010 · Cited by 11 · see citing works

Neuroprotective potential of methanolic extract of Saraca asoca bark against doxorubicin-induced neurotoxicity

Kumar, N., Cheruku, S., Chamallamudi, M., Ramalingayya, G. V., Biswas, S., Gourishetti, K., Nandakumar, K., Devkar, R. A., Mallik, S., & Nampoothiri, M. (2019) · Pharmacognosy Magazine · doi:10.4103/pm.pm_79_18 · Cited by 10 · see citing works

Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives

Oh, E., Garg, S., Liu, Y., Afzal, S., Gao, R., Yun, C., Kaul, S. C., & Wadhwa, R. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00552 · Cited by 8 · see citing works

Cell-Based Systems of Depression: An Overview

Jantas, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-14021-6_3 · Cited by 6 · see citing works

Three-Way Cell-Based Screening of Antistress Compounds: Identification, Validation, and Relevance to Old-Age-Related Pathologies

Zhang, H., Wang, J., Prakash, J., Zhang, Z., Kaul, S. C., & Wadhwa, R. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad103 · Cited by 5 · see citing works

Asymmetrical Dimethylarginine Antagonizes Glutamate-Induced Apoptosis in PC12 Cells

Wang, X., Zhao, J., & Yang, H. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9897-z · Cited by 5 · see citing works

Molecular and therapeutic insights into Withania somnifera (Ashwagandha) for cognition and neuroprotection

Shukla, S. D. (2025) · Academia Biology · doi:10.20935/acadbiol7925 · Cited by 4 · see citing works

Protective role of natural products and bioactive compounds in multiple sclerosis

Bhatti, G. K., Singh, H. V., Sharma, E., Sehrawat, A., Mishra, J., Navik, U., Reddy, P. H., & Bhatti, J. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00026-3 · Cited by 4 · see citing works

Neuroprotective Potential of Withania Somnifera in Cerebral Ischemia

Raghavan, A. (2014) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 3 · see citing works

Therapeutic Approach of Phytomedicine for Dementia: A Review

Singh, S. K., & Gupta, N. (2023) · Current Traditional Medicine · doi:10.2174/2215083810666230623160622 · Cited by 2 · see citing works

Therapeutic Potential of Withania somnifera in CNS Disorders: A Neuropharmacological Review

Ruhela, R. K., Soni, S., & Medhi, B. (2016) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2016/24187 · Cited by 2 · see citing works

Ashwagandha for Brain Health: Experimental Evidence for Its Neuroregenerative Activities

Wadhwa, R., Kalra, R. S., Chaudhary, A., & Kaul, S. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_14 · Cited by 2 · see citing works

PSA mimetic 5-nonyloxytryptamine protects cerebellar neurons against glutamate induced excitotoxicity: An in vitro perspective

Kalotra, S., & Kaur, G. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.11.003 · Cited by 2 · see citing works

The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders

Chengappa, K. N. R., Gannon, J. M., Acharya, L., & Rai, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_17 · Cited by 1 · see citing works

Neuromodulatory Role of Withania somnifera

Kaur, G., Kaur, T., Gupta, M., & Manchanda, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_20 · Cited by 1 · see citing works

Therapeutic Effect of Withania somnifera (Ashwagandha) on Depression: A comprehensive review

Ibrahim, M., Pawar, G., Khan, N., Gudalwar, B. R., Khan, S., & Mazhar, M. (2024) · Natural Resources for Human Health · doi:10.53365/nrfhh/177661 · Cited by 1 · see citing works

A Comparative Study of the Polysialylation Inhibition in the Kelly Neuroblastoma Cell Line by Withania somnifera and Bacopa monnieri Extracts

Al-Hasawi, N. A. (2017) · International journal of applied research in natural products · Cited by 1 · see citing works

Why Ashwagandha for Healthy Ageing? Evidence from Cultured Human Cells

Wadhwa, R., Garg, S., Khurana, M., & Kaul, S. C. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-83017-5_28 · Cited by 1 · see citing works

Herbal Drugs

Malik, J. (2017) · Wiley eBooks · doi:10.1002/9781119155195.ch10 · Cited by 1 · see citing works

Protective Effect of Methylene Blue on Neuronal Damage Induced by Okadaic Acid in Differentiated SK-N-SH Neuroblastoma Cells

Yingying, S., Yuting, Y., Qiu, L., Huanhuan, L., Zhou, H., Xu, B., Li, G., Li, J., & Wang, Z. (2016)

Pharmacological perspectives and phytochemical reservoir of Withania somnifera: A review

Srivastava, Y., Upadhyay, S., & Gupta, P. (2021) · International Journal of Multidisciplinary Research Configuration · doi:10.52984/ijomrc1102

Role of Medicinal Plants in the Management of Multiple Sclerosis

Gupta, A., Roy, A., Roy, A., Raja, V., Sharma, K., & Verma, R. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010324850240923181408

Neuroprotective potential of indian herbs in ischaemic stroke: a comprehensive review of pharmacological insights, therapeutic gaps, and future directions

Pandhare, D., & Ugale, R. R. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02019-y

Current and future prospectus of Withania somnifera L.: An overview

Upadhyay, R. K., & Pandey, P. (2025) · Environment Conservation Journal · doi:10.36953/ecj.34773170

Comparative analysis of withanolide accumulation in leaves and calli of Withania somnifera (L.) Dunal grown in different soil provenances

Gupta, M. K., Poonia, V., & Vimala, Y. (2026) · Vegetos · doi:10.1007/s42535-026-01739-y

Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway

Dar, N. J., Satti, N. K., Dutt, P., Hamid, A., & Ahmad, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0515-5 · Cited by 57 · see citing works

Ashwagandha extract protects against glutamate-induced cytotoxicity in retinoic acid differentiated C6 glioma cells

Kataria, H., & Kaur, G. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.09.1418

Neuroprotective response of the hippocampus region of the brain to Withania somnifera and Asparagus racemosus root extract: An in vitro study

Maheep, B., Prahlad, M., Satyendra, B., & Chetan, J. (2013) · Journal of Medicinal Plants Research · doi:10.5897/jmpr12.497 · Cited by 14 · see citing works

Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells

Dar, N. J., Bhat, J. A., Satti, N. K., Sharma, P. R., Hamid, A., & Ahmad, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0044-7 · Cited by 69 · see citing works

Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation

Shah, N., Singh, R., Sarangi, U., Saxena, N., Chaudhary, A., Kaur, G., Kaul, S. C., & Wadhwa, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120554 · Cited by 73 · see citing works