The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
Open accessAbstract
C57BL/6 (B6) mice subjected to a high-fat diet develop metabolic syndrome with obesity, hyperglycemia, and insulin resistance, whereas 129S6/SvEvTac (129) mice are relatively protected from this disorder because of differences in higher basal energy expenditure in 129 mice, leading to lower weight gain. At a molecular level, this difference correlates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncoupling in vitro in mitochondria isolated from muscle of 129 versus B6 mice. Detailed histological examination, however, reveals that this UCP1 is in mitochondria of brown adipocytes interspersed between muscle bundles. Indeed, the number of UCP1-positive brown fat cells in intermuscular fat in 129 mice is >700-fold higher than in B6 mice. These brown fat cells are subject to further up-regulation of UCP1 after stimulation with a β 3 -adrenergic receptor agonist. Thus, ectopic deposits of brown adipose tissue in intermuscular depots with regulatable expression of UCP1 provide a genetically based mechanism of protection from weight gain and metabolic syndrome between strains of mice.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In rodents, small collections of physiologically relevant BAT have been found in the hindlimb in intermuscular adipose tissue and mixed with white fat 86,87.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [86]
In the citing paper
“These systemic brown adipocytes are often found admixed with white fat cells; are more sensitive to β3-adrenergic stimulation and cold exposure; and their thermogenic capacity appears to be regulated by genetic background 86,87,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [86]
In the citing paper
“However, the recent identification of brown adipocytes interspersed between muscle bundles in mice 86 opens up the question whether some of the measured NST energy expenditure in skeletal muscle comes from these interspersed brown adipocytes.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [86]
Citations
Cites
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Thermogenic mechanisms in brown fat.
Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379
Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain
Ravussin, E., Lillioja, S., Knowler, W. C., Christin, L., Freymond, D., Abbott, W. G. H., Boyce, V., Howard, B. V., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802253180802 · Cited by 1,215
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075
Hotamışlıgil, G. S., Johnson, R. S., Distel, R. J., Ellis, R., Papaioannou, V. E., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5291.1377 · Cited by 915
Parental transmission of type 2 diabetes: the Framingham Offspring Study
Meigs, J. B., Cupples, L. A., & Wilson, P. W. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2201 · Cited by 666
Research works printed but not linked: 1
- G Garruti, D Ricquier Int J Obes Relat Metab Disord 16, 383–390 (1992).
Cited by
Sorted by citations
Items 101–200 of 284
Puri, V., Virbasius, J. V., Guilherme, A., & Czech, M. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01786.x · Cited by 65
Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
Braga, M., Pervin, S., Norris, K. C., Bhasin, S., & Singh, R. (2013) · Obesity · doi:10.1002/oby.20117 · Cited by 65
CAMERA, D. M., Anderson, M. J., Hawley, J. A., & Carey, A. L. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1356-3 · Cited by 64
Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease
Parra-Peralbo, E., Talamillo, A., & Barrio, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.786129 · Cited by 66
Brown Fat and Skeletal Muscle: Unlikely Cousins?
Farmer, S. R. (2008) · Cell · doi:10.1016/j.cell.2008.08.018 · Cited by 60
The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice
Glendinning, J. I., Gillman, J. A. M., Zamer, H., Margolskee, R. F., & Sclafani, A. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.05.023 · Cited by 60
Chausse, B., Solon, C., da Silva, C. C. C., dos Reis, I. G. M., Manchado-Gobatto, F. D. B., Gobatto, C. A., Velloso, L. A., & Kowaltowski, A. J. (2014) · Endocrinology · doi:10.1210/en.2013-2057 · Cited by 59
Zizola, C. F., Schwartz, G. J., & Vogel, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90464.2008 · Cited by 61
Programming research: where are we and where do we go from here?
Koletzko, B. V., Symonds, M. E., & Olsen, S. F. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018903 · Cited by 57
Winn, N. C., Vieira‐Potter, V. J., Gastecki, M. L., Welly, R. J., Scroggins, R. J., Zidon, T. M., Gaines, T. L., Woodford, M. L., Karasseva, N. G., Kanaley, J. A., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00425.2016 · Cited by 59
Gorski, T., Mathes, S., & Krützfeldt, J. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12277 · Cited by 56
Adipose tissue development – Impact of the early life environment
Symonds, M. E., Budge, H., Perkins, A. C., & Lomax, M. A. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.11.008 · Cited by 58
Rossi, A. P., Zoico, E., Goodpaster, B. H., Sepe, A., Francesco, V. D., Fantin, F., Pizzini, F. B., Corzato, F., Vitali, A., Micciolo, R., et al. (2010) · Obesity · doi:10.1038/oby.2010.48 · Cited by 55
Self-citationCentral Leptin Activates Mitochondrial Function and Increases Heat Production in Skeletal Muscle
Henry, B. A., Andrews, Z. B., Rao, A., & Clarke, I. J. (2011) · Endocrinology · doi:10.1210/en.2011-0143 · Cited by 55
Mitochondrial ion transport pathways: Role in metabolic diseases
Cardoso, A. R., Queliconi, B. B., & Kowaltowski, A. J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.12.017 · Cited by 54
Henry, B. A., Dunshea, F. R., Gould, M., & Clarke, I. J. (2007) · Endocrinology · doi:10.1210/en.2007-1311 · Cited by 54
Dadomo, H., Sanghez, V., Di Cristo, L., Lori, A., Ceresini, G., Malinge, I., Parmigiani, S., Palanza, P., Sheardown, M., & Bartolomucci, A. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.016 · Cited by 54
A novel method for the quantification of fatty infiltration in skeletal muscle
Biltz, N. K., & Meyer, G. A. (2017) · Skeletal Muscle · doi:10.1186/s13395-016-0118-2 · Cited by 55
Li, L., Hossain, M. A., Sadat, S., Hager, L., Liu, L., Tam, L., Schroer, S. A., Lu, H., Fantus, I. G., Connelly, P. W., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180893 · Cited by 51
Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity
Rachid, B., van de Sande‐Lee, S., Rodovalho, S., Folli, F. B., Beltramini, G. C., Morari, J., Amorim, B. J., Pedro, T., Ramalho, A. F. S., Bombassaro, B., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.94 · Cited by 51
Deconstructing cold-induced brown adipocyte neogenesis in mice
Burl, R. B., Rondini, E. A., Wei, H., Piqué-Regi, R., & Granneman, J. G. (2022) · eLife · doi:10.7554/elife.80167 · Cited by 51
In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI
Branca, R. T., Zhang, L., Warren, W. S., Auerbach, E. J., Khanna, A., Degan, S., Uǧurbil, K., & Maronpot, R. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074206 · Cited by 49
Ahmadi, N., Hajsadeghi, F., Conneely, M., Mingos, M., Arora, R. R., Budoff, M. J., & Ebrahimi, R. (2013) · Academic Radiology · doi:10.1016/j.acra.2013.08.012 · Cited by 48
Browning attenuates murine white adipose tissue expansion during postnatal development
Lasar, D., Grolleau‐Julius, A., Fromme, T., & Klingenspor, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.016 · Cited by 48
Baloğlu, F. K., Garip, Ş., Heise, S., Brockmann, G. A., & Severcan, F. (2015) · The Analyst · doi:10.1039/c4an02008a · Cited by 47
Diet-induced changes in Ucp1 expression in bovine adipose tissues
Asano, H., Yamada, T., Hashimoto, O., Umemoto, T., Sato, R., Ohwatari, S., Kanamori, Y., Terachi, T., Funaba, M., & Matsui, T. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.01.006 · Cited by 49
Brown adipose tissue growth and development: significance and nutritional regulation
Satterfield, M. C. (2010) · Frontiers in bioscience · doi:10.2741/3807 · Cited by 46
Wang, Z., Liu, X., Jiang, K., Kim, H., Kajimura, S., & Feeley, B. T. (2020) · The American Journal of Sports Medicine · doi:10.1177/0363546520910421 · Cited by 46
Monteiro, B. S., Freire‐Brito, L., Carrageta, D. F., Oliveira, P. F., & Alves, M. G. (2021) · Antioxidants · doi:10.3390/antiox10111746 · Cited by 49
Buchner, D. A., Yazbek, S. N., Solinas, P., Burrage, L. C., Morgan, M. G., Hoppel, C. L., & Nadeau, J. H. (2010) · Obesity · doi:10.1038/oby.2010.214 · Cited by 47
Gutierrez, A. D., Gao, Z., Hamidi, V., Zhu, L., Saint Andre, K. B., Riggs, K., Ruscheinsky, M., Wang, H., Yu, Y., Miller, C., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100813 · Cited by 44
Thermogenic adipocytes: From cells to physiology and medicine
Díaz, M. B., Herzig, S., & Vegiopoulos, A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.002 · Cited by 45
Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research
Castro, M., Preto, M., Vasconcelos, V. M., & Urbatzka, R. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160415155644 · Cited by 44
Is p53 Involved in Tissue‐Specific Insulin Resistance Formation?
Strycharz, J., Drzewoski, J., Szemraj, J., & Śliwińska, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9270549 · Cited by 45
The Genetics of Brown Adipocyte Induction in White Fat Depots
Kozak, L. P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00064 · Cited by 41
Chung, Y. W., Ahmad, F., Tang, Y., Hockman, S. C., Kee, H. J., Berger, K., Guirguis, E., Choi, Y. H., Schimel, D., Aponte, A. M., et al. (2017) · Scientific Reports · doi:10.1038/srep40445 · Cited by 45
Ngoc, H. L., Shin, S., Tu, T. H., Kim, C.-S., Kang, J., Goto, T., Teruo, K., Han, S. N., & Yu, R. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303548k · Cited by 41
Essential roles of 11β-HSD1 in regulating brown adipocyte function
Liu, J., Kong, X., Wang, L., Qi, H., Di, W., Zhang, X., Wu, L., Chen, X., Yu, J., Zha, J., et al. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0099 · Cited by 41
Miao, Y., Wu, W., Dai, Y., Maneix, L., Huang, B., Warner, M. N., & Gustafsson, J.-Α. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519358112 · Cited by 39
Shen, W., & McIntosh, M. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050924 · Cited by 40
Mitochondrial proton leak in obesity-resistant and obesity-prone mice
Fink, B. D., Herlein, J. A., Almind, K., Cinti, S., Kahn, C. R., & Sivitz, W. I. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00478.2007 · Cited by 40
Self-citationAdiponectin as a Biomarker of Osteoporosis in Postmenopausal Women: Controversies
Lubkowska, A., Dobek, A., Mieszkowski, J., Garczyński, W., & Chlubek, D. (2014) · Disease Markers · doi:10.1155/2014/975178 · Cited by 39
Bone morphogenic proteins signaling in adipogenesis and energy homeostasis
Modica, S., & Wolfrum, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.010 · Cited by 41
Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains
Li, Y., Bolze, F., Fromme, T., & Klingenspor, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.06.003 · Cited by 38
Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status
Gavrila, A., Hasselgren, P.-O. J., Glasgow, A. L., Doyle, A. N., Lee, A. J., Fox, P. T., Gautam, S., Hennessey, J. V., Kolodny, G. M., & Cypess, A. M. (2016) · Thyroid · doi:10.1089/thy.2015.0646 · Cited by 38
Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice
Morton, T. L., Galior, K. D., McGrath, C., Wu, X., Uzer, G., Uzer, G. B., Sen, B., Xie, Z., Tyson, D. G. W., Rubin, J. E., et al. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00080 · Cited by 37
Bourebaba, Y., Mularczyk, M., Marycz, K., & Bourebaba, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111113 · Cited by 39
Jiang, J., Li, P., Ling, H., Xu, Z., Yi, B., & Zhu, S. (2018) · Human Cell · doi:10.1007/s13577-018-0210-5 · Cited by 35
Kwakkel, J., Chassande, O., van Beeren, H. C., Fliers, E., Wiersinga, W. M., & Boelen, A. (2010) · Endocrinology · doi:10.1210/en.2009-1049 · Cited by 34
Larsen, P. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0791 · Cited by 37
Brown adipose tissue detected by PET/CT imaging is associated with less central obesity
Green, A. L., Bağcı, U., Hussein, S., Kelly, P. V., Muzaffar, R., Neuschwander‐Tetri, B. A., & Osman, M. (2017) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000691 · Cited by 34
Conjugated Linoleic Acid Induces Uncoupling Protein 1 in White Adipose Tissue of ob/ob Mice
Wendel, A. A., Purushotham, A., Liu, L., & Belury, M. A. (2009) · Lipids · doi:10.1007/s11745-009-3348-9 · Cited by 33
Thrush, A. B., Dent, R., McPherson, R., & Harper, M. (2013) · FEBS Journal · doi:10.1111/febs.12399 · Cited by 36
Gómez‐Hernández, A., Otero, Y. F., Heras, N. D. L., Escribano, Ó., Cachofeiro, V., Lahera, V., & Benito, M. (2012) · Endocrinology · doi:10.1210/en.2011-1765 · Cited by 33
Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid
Zhao, L., Wang, S., Zhu, Q., Wu, B., Liu, Z., OuYang, B., & Chou, J. J. (2017) · Structure · doi:10.1016/j.str.2017.07.005 · Cited by 34
PWD/PhJ and WSB/EiJ Mice Are Resistant to Diet-Induced Obesity But Have Abnormal Insulin Secretion
Lee, K. T. Y., Karunakaran, S., Ho, M. M., & Clee, S. M. (2011) · Endocrinology · doi:10.1210/en.2011-0060 · Cited by 34
Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes
Townsend, K. L., & Tseng, Y.-H. (2015) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2015.5 · Cited by 32
Laharrague, P. F., & Casteilla, L. (2010) · Endocrine development · doi:10.1159/000316894 · Cited by 32
Brown and beige fat: the metabolic function, induction, and therapeutic potential
Qian, S., Huang, H., & Tang, Q. (2015) · Frontiers of Medicine · doi:10.1007/s11684-015-0382-2 · Cited by 33
Biniaminov, N., Bandt, S., Röth, A., Haertel, S., Neumann, R., & Bub, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0189254 · Cited by 29
Xiang, A. S., Meikle, P. J., Carey, A. L., & Kingwell, B. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.002 · Cited by 29
Obesity as an immune-modifying factor in cancer immunotherapy
Canter, R. J., Le, C. T., Beerthuijzen, J. M. T., & Murphy, W. J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.5ri1017-401rr · Cited by 30
Adipose Tissue and Modulation of Hypertension
Das, E., Moon, J. H., Lee, J. H., Thakkar, N., Pausová, Z., & Sung, H. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0894-7 · Cited by 33
Norris, A. M., Fierman, K. E., Campbell, J., Pitale, R., Shahraj, M., & Kopinke, D. (2024) · Skeletal Muscle · doi:10.1186/s13395-024-00344-4 · Cited by 28
Exosomal circRNAs: Novel biomarkers and therapeutic targets for gastrointestinal tumors
Wang, D., Li, R., Jiang, J., Qian, H., & Xu, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114053 · Cited by 29
Ngala, R. A., O’Dowd, J. F., Wang, S. J., Agarwal, A., Stocker, C. J., Cawthorne, M. A., & Arch, J. R. S. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.244 · Cited by 28
Ng, D. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.12.012 · Cited by 28
White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals
Li, Y., Lasar, D., Fromme, T., & Klingenspor, M. (2013) · Canadian Journal of Zoology · doi:10.1139/cjz-2013-0165 · Cited by 29
Imai, Y., Fink, B. D., Promes, J. A., Kulkarni, C. A., Kerns, R. J., & Sivitz, W. I. (2018) · Pharmacology Research & Perspectives · doi:10.1002/prp2.393 · Cited by 27
Self-citationKozak, L. P., Koza, R. A., Anunciado‐Koza, R. P., Mendoza, T. M., & Newman, S. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030392 · Cited by 27
Association between cold dialysis and cardiovascular survival in hemodialysis patients
Hsu, H.-J., Yen, C.-H., Hsu, K., Lee, C., Chang, S., Wu, I., Sun, C., Chou, C.-C., Yu, C.-C., Hsieh, M.-F., et al. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr615 · Cited by 27
Opportunities and challenges in three-dimensional brown adipogenesis of stem cells
Unser, A. M., Tian, Y. I., & Xie, Y. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.07.005 · Cited by 29
Budge, H., Sebert, S. P., Sharkey, D., & Symonds, M. E. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109001402 · Cited by 28
Dietary conjugated linoleic acid and medium-chain triglycerides for obesity management
Ibrahim, K. S., & El-Sayed, E. M. (2021) · Journal of Biosciences · doi:10.1007/s12038-020-00133-3 · Cited by 27
Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes
Werneck‐de‐Castro, J. P., Fonseca, T. L., Ignacio, D. L., Fernandes, G. W., Andrade-Feraud, C. M., Lartey, L. J., Ribeiro, M. B., Ribeiro, M. O., Gereben, B., & Bianco, A. C. (2015) · Endocrinology · doi:10.1210/en.2015-1246 · Cited by 27
Brown adipose tissue: the molecular mechanism of its formation
Wolf, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00184.x · Cited by 26
Nakayama, K., Ogawa, A., Miyashita, H., Tabara, Y., Igase, M., Kohara, K., Miki, T., Kagawa, Y., Yanagisawa, Y., Katashima, M., et al. (2012) · Human Genetics · doi:10.1007/s00439-012-1240-9 · Cited by 26
Clarke, S. D., Lee, K., Andrews, Z. B., Bischof, R. J., Fahri, F., Evans, R. G., Clarke, I. J., & Henry, B. A. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00036.2012 · Cited by 25
Adipose tissue inflammation and cancer cachexia: the role of steroid hormones
Seelaender, M. C. L., & Júnior, M. L. B. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0040 · Cited by 25
TSH promotes adiposity by inhibiting the browning of white fat
Zhang, J., Wu, H., Ma, S., Gao, L., Yu, C., Jing, F., & Zhao, J. (2020) · Adipocyte · doi:10.1080/21623945.2020.1783101 · Cited by 24
Clarke, S. D., Clarke, I. J., Rao, A., Evans, R. G., & Henry, B. A. (2012) · Endocrinology · doi:10.1210/en.2012-1758 · Cited by 24
Identification of a natural beige adipose depot in mice
Chan, M., Lim, Y. C., Yang, J. L., Namwanje, M., Liu, L., & Qiang, L. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006838 · Cited by 24
The Genetics of Brown Adipose Tissue
Kozak, L. P., & Koza, R. A. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-375003-7.00004-2 · Cited by 23
Global Adipose Tissue Remodeling During the First Month of Postnatal Life in Mice
Bruder, J., & Fromme, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.849877 · Cited by 22
Baboota, R. K., Sarma, S. M., Boparai, R. K., Kondepudi, K. K., Mantri, S. S., & Bishnoi, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127701 · Cited by 25
Discovery of Novel and Differentially Expressed MicroRNAs between Fetal and Adult Backfat in Cattle
Sun, J., Zhou, Y., Cai, H., Lan, X., Lei, C., Zhao, X., Zhang, C., & Chen, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090244 · Cited by 22
Zhang, T., Li, J., Li, X., & Liu, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1280853 · Cited by 21
Hollstein, T., Vinales, K. L., Chen, K. Y., Cypess, A. M., Basolo, A., Schlögl, M., Krakoff, J. A., & Piaggi, P. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154709 · Cited by 20
Tapía, P., Fernández‐Galilea, M., Robledo, F., Mardones, P., Galgani, J. E., & Cortés, V. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12389 · Cited by 21
Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence
Hollstein, T., & Piaggi, P. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00371-4 · Cited by 24
Daquinag, A. C., Gao, Z., Yu, Y., & Kolonin, M. G. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101544 · Cited by 19
Gender Dimorphism in Skeletal Muscle Proteome Between Lean and Diet-induced Obese Rats
Oh, T. S., Choi, J., Choi, D. K., Mukherjee, R., Liu, H., & Yun, J. W. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000335811 · Cited by 19
Gadéa, É., Thivat, É., Paulon, R., Mishellany, F., Gimbergues, P., Capel, F., Mosoni, L., Merlin, C., Lombès, M., Morio, B., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2829 · Cited by 18
Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning
Li, Y., Schwalie, P. C., Bast‐Habersbrunner, A., Mocek, S., Russeil, J., Fromme, T., Deplancke, B., & Klingenspor, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.053 · Cited by 16
Targeting energy expenditure in muscle as a means of combating obesity
Clarke, I. J., & Henry, B. A. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05259.x · Cited by 16
Effect of ethanolic extract of Cuscuta reflexa on high fat diet- induced obesity in Wistar rats
Kaur, A., Behl, T., Makkar, R., & Goyal, A. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.02.001 · Cited by 16
Brown Adipose Tissue in the Buccal Fat Pad during Infancy
Ponrartana, S., Patil, S., Aggabao, P. C., Pavlova, Z., Devaskar, S. U., & Gilsanz, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089533 · Cited by 16
Cutler, H. B., Jall-Rogg, S., Thillainadesan, S., Cooke, K. C., Masson, S. W. C., Sligar, J., Crowston, J. G., Carroll, L., Stöckli, J., James, D. E., et al. (2025) · Science Advances · doi:10.1126/sciadv.adt7369 · Cited by 18
Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation
Addison, W. N., Hall, K. C., Kokabu, S., Matsubara, T., Fu, M. M.-J., Gori, F., & Baron, R. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00447-18 · Cited by 15
Le recrutement et l’activation d’adipocytes bruns et/ou BRITE
Carrière, A., Jeanson, Y., Cousin, B., Arnaud, E., & Casteilla, L. (2013) · médecine/sciences · doi:10.1051/medsci/2013298011 · Cited by 18
Metadata
- Authors
- Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., & Kahn, C. R.
- Affiliations
- Joslin Diabetes Center (US)
- Institute of Normal Human Morphology and Anatomy, University of Ancona, 6013 Ancona, Italy; and
- University of Iowa (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-02-13
- Volume
- 104
- Issue
- 7
- Pages
- 2366-2371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1892979
- OpenAlex
- W2038657829
- Cited by
- 286
- References
- 43
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 11 · 2019: 7 · 2018: 16 · 2017: 17 · 2016: 11 · 2015: 18 · 2014: 21 · 2013: 35 · 2012: 20
- FWCI
- 16.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- National Institutes of Health (DK31036)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK031036, DK 30136, R01DK031036, DK45935, DK-60837, R01DK045935, R01DK060837)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- intermuscular fat, UCP1, metabolic syndrome, high-fat diet, obesity, insulin resistance, hyperglycemia, energy expenditure, beta3-adrenergic agonists, brown adipocytes, C57BL/6 mice, strain differences, mitochondrial uncoupling
- MeSH terms
- Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Dietary Fats, Energy Metabolism, Ion Channels, Mice, Inbred C57BL, Mice, Inbred Strains, Mitochondria, Muscles, Risk, Weight Gain, Up-Regulation, Mitochondrial Proteins, Metabolic Syndrome, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review