The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
Open accessAbstract
C57BL/6 (B6) mice subjected to a high-fat diet develop metabolic syndrome with obesity, hyperglycemia, and insulin resistance, whereas 129S6/SvEvTac (129) mice are relatively protected from this disorder because of differences in higher basal energy expenditure in 129 mice, leading to lower weight gain. At a molecular level, this difference correlates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncoupling in vitro in mitochondria isolated from muscle of 129 versus B6 mice. Detailed histological examination, however, reveals that this UCP1 is in mitochondria of brown adipocytes interspersed between muscle bundles. Indeed, the number of UCP1-positive brown fat cells in intermuscular fat in 129 mice is >700-fold higher than in B6 mice. These brown fat cells are subject to further up-regulation of UCP1 after stimulation with a β 3 -adrenergic receptor agonist. Thus, ectopic deposits of brown adipose tissue in intermuscular depots with regulatable expression of UCP1 provide a genetically based mechanism of protection from weight gain and metabolic syndrome between strains of mice.
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In the citing paper
“In rodents, small collections of physiologically relevant BAT have been found in the hindlimb in intermuscular adipose tissue and mixed with white fat 86,87.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [86]
In the citing paper
“These systemic brown adipocytes are often found admixed with white fat cells; are more sensitive to β3-adrenergic stimulation and cold exposure; and their thermogenic capacity appears to be regulated by genetic background 86,87,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [86]
In the citing paper
“However, the recent identification of brown adipocytes interspersed between muscle bundles in mice 86 opens up the question whether some of the measured NST energy expenditure in skeletal muscle comes from these interspersed brown adipocytes.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [86]
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Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Self-citationPRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Self-citationMitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Liesa, M., & Shirihai, O. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.002 · Cited by 1,341
Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263
Metadata
- Authors
- Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., & Kahn, C. R.
- Affiliations
- Joslin Diabetes Center (US)
- Institute of Normal Human Morphology and Anatomy, University of Ancona, 6013 Ancona, Italy; and
- University of Iowa (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-02-13
- Volume
- 104
- Issue
- 7
- Pages
- 2366-2371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1892979
- OpenAlex
- W2038657829
- Cited by
- 286
- References
- 43
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 11 · 2019: 7 · 2018: 16 · 2017: 17 · 2016: 11 · 2015: 18 · 2014: 21 · 2013: 35 · 2012: 20
- FWCI
- 16.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- National Institutes of Health (DK31036)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK031036, DK 30136, R01DK031036, DK45935, DK-60837, R01DK045935, R01DK060837)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- intermuscular fat, UCP1, metabolic syndrome, high-fat diet, obesity, insulin resistance, hyperglycemia, energy expenditure, beta3-adrenergic agonists, brown adipocytes, C57BL/6 mice, strain differences, mitochondrial uncoupling
- MeSH terms
- Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Dietary Fats, Energy Metabolism, Ion Channels, Mice, Inbred C57BL, Mice, Inbred Strains, Mitochondria, Muscles, Risk, Weight Gain, Up-Regulation, Mitochondrial Proteins, Metabolic Syndrome, Mice
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