Thyroid Hormone Receptor α Modulates Lipopolysaccharide-Induced Changes in Peripheral Thyroid Hormone Metabolism
Abstract
Acute inflammation is characterized by low serum T3 and T4 levels accompanied by changes in liver type 1 deiodinase (D1), liver D3, muscle D2, and muscle D3 expression. It is unknown at present whether thyroid hormone receptor α (TRα) plays a role in altered peripheral thyroid hormone metabolism during acute illness in vivo. We induced acute illness in TRα-deficient (TRα0/0) mice by administration of a sublethal dose of LPS. Compared with wild-type, TRα0/0 mice have lower basal serum T4 and lower liver D1 activity and muscle D3 mRNA expression, whereas liver D3 activity is higher. These changes are gender specific. The inflammatory response to LPS was similar in WT and TRα0/0 mice. The decrease in serum thyroid hormones and liver D1 was attenuated in TRα0/0 mice, whereas the LPS induced fall in liver D3 mRNA was more pronounced in TRα0/0 mice. Muscle D2 mRNA increased similarly in both strains, whereas muscle D3 mRNA decreased less pronounced in TRα0/0 mice. We conclude that alterations in peripheral thyroid hormone metabolism induced by LPS administration are partly regulated via TRα.
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Acute inflammation in mice decreases muscle DIO3 while chronic inflammation in the same species increases muscle DIO3.
“Acute inflammation in mice decreases muscle DIO3 [31] while chronic inflammation in the same species increases muscle DIO3.”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [31]
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- Authors
- Kwakkel, J., Chassande, O., van Beeren, H. C., Fliers, E., Wiersinga, W. M., & Boelen, A.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Inserm (FR)
- Department of Endocrinology and Metabolism (J.K., H.C.B., E.F., W.M.W., A.B.), Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;
- Corresponding author
- Kwakkel, Joan
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-03-01
- Volume
- 151
- Issue
- 4
- Pages
- 1959-1969
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2096799980
- Cited by
- 34
- References
- 45
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Universiteit van Amsterdam
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- thyroid hormone receptor alpha, lipopolysaccharide, acute inflammation, type I deiodinase, type 2 deiodinase, type 3 deiodinase, serum thyroid hormones, liver, skeletal muscle, sex differences
- MeSH terms
- Analysis of Variance, Animals, Female, Inflammation, Iodide Peroxidase, Lipopolysaccharides, Liver, Male, Radioimmunoassay, Thyroid Hormones, Mice, Knockout, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Thyroid Hormone Receptors alpha, Mice
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