The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2
Open accessAbstract
There is increasing evidence that innate and adaptive immune responses are intimately linked. This linkage is in part mediated through the recognition of conserved microbial products by Toll-like receptors (TLRs). Detection of microbial products by TLRs can result in induction of inflammatory cytokines and activation of professional antigen-presenting cells, thereby enhancing adaptive immune responses. Here, we show that human β-defensin-3 (hBD-3), an innate antimicrobial peptide, can induce expression of the costimulatory molecules CD80, CD86, and CD40, on monocytes and myeloid dendritic cells in a TLR-dependent manner. Activation of monocytes by hBD-3 is mediated by interaction with TLRs 1 and 2, resulting in signaling that requires myeloid differentiating factor 88 and results in IL-1 receptor-associated kinase-1 phosphorylation. In studies with HEK cells engineered to express various TLRs, we show that activation of NF-κB by hBD-3 depends on the expression of both TLR1 and TLR2. Thus, human TLR signaling is not restricted to recognition of microbial patterns but also can be initiated by host-derived peptides such as hBD-3.
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Cites
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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products
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Epithelial crosstalk at the microbiota–mucosal interface
Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 579
Danger‐associated molecular patterns ( DAMPs ) in acute lung injury
Tolle, L. B., & Standiford, T. J. (2013) · The Journal of Pathology · doi:10.1002/path.4124 · Cited by 157
Air Pollution Particulate Matter Alters Antimycobacterial Respiratory Epithelium Innate Immunity
Rivas-Santiago, C. E., Sarkar, S., Cantarella, P., Osornio-Vargas, Á., Quintana-Belmares, R., Meng, Q., Kirn, T. J., Ohman Strickland, P., Chow, J. C., Watson, J. G., et al. (2015) · Infection and Immunity · doi:10.1128/iai.03018-14 · Cited by 150
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Metadata
- Authors
- Funderburg, N., Lederman, M. M., Feng, Z., Drage, M. G., Jadlowsky, J., Harding, C. V., Weinberg, A., & Sieg, S. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-11-20
- Volume
- 104
- Issue
- 47
- Pages
- 18631-18635
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2126734687
- Cited by
- 373
- References
- 32
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Funderburg, N., Lederman, M. M., Feng, Z., Drage, M. G., Jadlowsky, J., Harding, C. V., Weinberg, A., & Sieg, S. F. (2007). Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0702130104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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