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Cited by 421

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

Open access
Hikida, Takatoshi, Jaaro-Peled, Hanna, Seshadri, Saurav, Oishi, Kenichi, Hookway, Caroline, Kong, Stephanie, Wu, Di, Xue, Rong, Andradé, Manuella, Tankou, Stephanie, Mori, Susumu, Gallagher, Michela, Ishizuka, Koko, Pletnikov, Mikhail, Kida, Satoshi, Sawa, Akira·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0704774104
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Abstract

Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negative form of DISC1 (DN-DISC1) is expressed under the αCaMKII promoter. In vivo MRI of the DN-DISC1 mice detected enlarged lateral ventricles particularly on the left side, suggesting a link to the asymmetrical change in anatomy found in brains of patients with schizophrenia. Furthermore, selective reduction in the immunoreactivity of parvalbumin in the cortex, a marker for an interneuron deficit that may underlie cortical asynchrony, is observed in the DN-DISC1 mice. These results suggest that these transgenic mice may be used as a model for schizophrenia. DN-DISC1 mice also display several behavioral abnormalities, including hyperactivity, disturbance in sensorimotor gating and olfactory-associated behavior, and an anhedonia/depression-like deficit.

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Research works printed but not linked: 36

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Metadata

Authors
Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S., & Sawa, A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2007-09-04
Volume
104
Issue
36
Pages
14501-14506
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0704774104
OpenAlex
W2136925527
Cited by
421
References
8
FWCI
19.65
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. https://app.cochat.ai/papers/10.1073/pnas.0704774104
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Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S., & Sawa, A. (2007). Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0704774104

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