Loss of T cell receptor-induced Bmi-1 in the KLRG1 + senescent CD8 + T lymphocyte

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Brummelkamp, T. R., Bernards, R., & Agami, R. (2002) · Science · doi:10.1126/science.1068999 · Cited by 4,295 · see citing works

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 3,960 · see citing works

T cell receptor antagonist peptides induce positive selection.

Hogquist, K., Jameson, S., Heath, W., Howard, J. L., Bevan, M., & Carbone, F. (1994) · Cell · doi:10.1016/0092-8674(94)90169-4 · Cited by 3,252 · see citing works

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871 · see citing works

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864 · see citing works

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · see citing works

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580 · see citing works

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Rubinson, D. A., Dillon, C. P., Kwiatkowski, A. V., Sievers, C., Yang, L., Kopinja, J. E., Rooney, D. L., Zhang, M., Ihrig, M. M., McManus, M. T., et al. (2003) · Nature Genetics · doi:10.1038/ng1117 · Cited by 1,499 · see citing works

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,301 · see citing works

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

Kaech, S. M., & Ahmed, R. (2001) · Nature Immunology · doi:10.1038/87720 · Cited by 1,277 · see citing works

Principles of Tumor Suppression

Sherr, C. J. (2004) · Cell · doi:10.1016/s0092-8674(03)01075-4 · Cited by 1,028 · see citing works

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

van Stipdonk, M. J. B., Lemmens, E. E., & Schoenberger, S. P. (2001) · Nature Immunology · doi:10.1038/87730 · Cited by 846 · see citing works

Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

Chang, J. T., Palanivel, V., Kinjyo, I., Schambach, F., Intlekofer, A. M., Banerjee, A., Longworth, S. A., Vinup, K. E., Mrass, P., Oliaro, J., et al. (2007) · Science · doi:10.1126/science.1139393 · Cited by 845 · see citing works

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.Preprint

van der Lugt, N. M. T., Domen, J., Linders, K., van ROON, M. A., Robanus-Maandag, E. C., Riele, H. T., van der Valk, M., Deschamps, J., Sofroniew, M. V., & van Lohuizen, M. (1994) · Genes & Development · doi:10.1101/gad.8.7.757 · Cited by 781 · see citing works

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

van Lohuizen, M., Verbeek, S. J., Scheljen, B., Wientjens, E., van der Guidon, H., & Berns, A. J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90382-9 · Cited by 762 · see citing works

Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals

Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754 · see citing works

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515 · see citing works

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

Haupt, Y., Alexander, W. S., Barri, G., Klinken, S. P., & Adams, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90383-a · Cited by 513 · see citing works

The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.

Dimri, G. P., Martínez‐Guitarte, J., Jacobs, J. J. L., Keblusek, P., Itahana, K., van Lohuizen, M., Campisi, J., Wazer, D. E., & Band, V. (2002) · PubMed · Cited by 361 · see citing works

Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)

Voehringer, D., Koschella, M., & Pircher, H. (2002) · Blood · doi:10.1182/blood-2002-02-0657 · Cited by 352 · see citing works

<i>Ink4a</i> and <i>Arf</i> differentially affect cell proliferation and neural stem cell self-renewal in <i>Bmi1</i>-deficient mice

Bruggeman, S. W. M., Valk-Lingbeek, M. E., van der Stoop, P. P. M., Jacobs, J. J. L., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., et al. (2005) · Genes &amp; Development · doi:10.1101/gad.1299305 · Cited by 315 · see citing works

Functional Properties and Lineage Relationship of CD8+ T Cell Subsets Identified by Expression of IL-7 Receptor α and CD62L

Bachmann, M. F., Wolint, P., Schwarz, K., Jäger, P., & Oxenius, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4686 · Cited by 274 · see citing works

Differential contributions of central and effector memory T cells to recall responses

Roberts, A. D., Ely, K. H., & Woodland, D. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050137 · Cited by 272 · see citing works

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

Wong, P., & Pamer, E. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.10.5864 · Cited by 269 · see citing works

Arrested differentiation, the self-renewing memory lymphocyte, and vaccination

Fearon, D. T., Manders, P., & Wagner, S. D. (2001) · Science · doi:10.1126/science.1062589 · Cited by 265 · see citing works

Viral infections induce abundant numbers of senescent CD8 T cells

Voehringer, D., Blaser, C., Brawand, P., Raulet, D. H., Hanke, T., & Pircher, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4838 · Cited by 246 · see citing works

Regulation of IL-4 Expression by Activation of Individual Alleles

Rivière, I., Sunshine, M. J., & Littman, D. R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80604-4 · Cited by 164 · see citing works

Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation

Thimme, R., Appay, V., Koschella, M., Panther, E., Roth, E., Hislop, A. D., Rickinson, A. B., Rowland‐Jones, S., Blum, H. E., & Pircher, H. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.12112-12116.2005 · Cited by 163 · see citing works

Lineage relationships, homeostasis, and recall capacities of central– and effector–memory CD8 T cells in vivo

Bouneaud, C., Garcia, Z., Kourilsky, P., & Pannetier, C. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040876 · Cited by 144 · see citing works

Human CD28−CD8+ T Cells Contain Greatly Expanded Functional Virus-Specific Memory CTL Clones

Weekes, M. P., Carmichael, A., Wills, M. R., Mynard, K., & Sissons, J. G. P. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7569 · Cited by 134 · see citing works

Virus-Induced CD8+ T Cell Clonal Expansion Is Associated with Telomerase Up-Regulation and Telomere Length Preservation: A Mechanism for Rescue from Replicative Senescence

Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N., & Beverley, P. C. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4521 · Cited by 110 · see citing works

Highly Protective In Vivo Function of Cytomegalovirus IE1 Epitope-Specific Memory CD8 T Cells Purified by T-Cell Receptor-Based Cell Sorting

Pahl-Seibert, M.-F., Jülch, M., Podlech, J., Thomas, D., Deegen, P., Reddehase, M. J., & Holtappels, R. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5400-5413.2005 · Cited by 107 · see citing works

A monoclonal antibody that inhibits secretion from rat basophilic leukemia cells and binds to a novel membrane component.

Soto, E. O., & Pecht, I. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.12.4324 · Cited by 91 · see citing works

BCL6b mediates the enhanced magnitude of the secondary response of memory CD8 + T lymphocytes

Manders, P., Hunter, P., Telaranta, A. I., Carr, J. M., Marshall, J. L., Carrasco, M. J., Murakami, Y., Palmowski, M. J., Cerundolo, V., Kaech, S. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501585102 · Cited by 81 · see citing works

Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte Immortalization

Migliaccio, M., Amacker, M., Just, T., Reichenbach, P., Valmori, D., Cerottini, J., Romero, P. J., & Nabholz, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4978 · Cited by 78 · see citing works

CD27 mediates interleukin-2-independent clonal expansion of the CD8 + T cell without effector differentiation

Carr, J. M., Carrasco, M. J., Thaventhiran, J. E. D., Bambrough, P. J., Kraman, M., Edwards, A. D., Al‐Shamkhani, A., & Fearon, D. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609706104 · Cited by 65 · see citing works

Induction of Telomerase Activity and Maintenance of Telomere Length in Virus-Specific Effector and Memory CD8+ T Cells

Hathcock, K. S., Kaech, S. M., Ahmed, R., & Hodes, R. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.147 · Cited by 59 · see citing works

Clonotype Tracking of TCR Repertoires during Chronic Virus Infections

Cohen, G. B., Islam, S. A., Noble, M. S., Lau, C., Brander, C., Altfeld, M. A., Rosenberg, E. S., Schmitz, J. E., Cameron, T. O., & Kalams, S. A. (2002) · Virology · doi:10.1006/viro.2002.1743 · Cited by 37 · see citing works

Cutting Edge: Central Memory T Cells Do Not Show Accelerated Proliferation or Tissue Infiltration in Response to Localized Herpes Simplex Virus-1 Infection

Stock, A. T., Jones, C. M., Heath, W. R., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1411 · Cited by 28 · see citing works

Short Communication Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking

Hasegawa, M., Tetsu, O., Kanno, R., et al. (1998) · Molecular Immunology · doi:10.1016/s0161-5890(98)00048-0 · Cited by 16 · see citing works

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

Crespo, J., Sun, H., Welling, T. H., Tian, Z., & Zou, W. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.003 · Cited by 752 · see citing works

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

Zhao, Y., Shao, Q., & Peng, G. (2020) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-019-0344-8 · Cited by 382 · see citing works

Metabolism in T cell activation and differentiation

Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314 · see citing works

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Liu, X., Mo, W., Ye, J., Li, L., Zhang, Y., Hsueh, E. C., Hoft, D. F., & Peng, G. (2018) · Nature Communications · doi:10.1038/s41467-017-02689-5 · Cited by 224 · see citing works

Biomarkers of human immunosenescence: impact of cytomegalovirus infection

Derhovanessian, E., Larbi, A., & Pawelec, G. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.012 · Cited by 220 · see citing works

Therapeutic Cancer Vaccines—T Cell Responses and Epigenetic Modulation

Kartikasari, A. E. R., Prakash, M. D., Cox, M., Wilson, K., Boer, J. C., Cauchi, J. A., & Plebanski, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03109 · Cited by 54 · see citing works

Characterization of mouse CD4 T cell subsets defined by expression of KLRG1

Beyersdorf, N., Ding, X., Tietze, J. K., & Hanke, T. (2007) · European Journal of Immunology · doi:10.1002/eji.200737126 · Cited by 81 · see citing works

Activated CD4+ CD25+ T cells suppress antigen‐specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells

Dieckmann, D., Plöttner, H., Dotterweich, S., et al. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02144.x · Cited by 37 · see citing works

Untitled work

Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

Annacker, O., Pimenta‐Araujo, R., Burlen‐Defranoux, O., Barbosa, T., Cumano, A., & Bandeira, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3008 · Cited by 553 · see citing works

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Thornton, A. M., & Shevach, E. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.287 · Cited by 2,637 · see citing works