Metabolism in T cell activation and differentiation

Pearce, Erika L

doi:10.1016/j.coi.2010.01.018

Cited by 314T-cell and B-cell ImmunologyCancer, Hypoxia, and MetabolismImmune cells in cancer

Metabolism in T cell activation and differentiation

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Pearce, Erika L·2010·Current Opinion in Immunology

DOI 10.1016/j.coi.2010.01.018PMC PMC4486663

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Abstract

When naïve or memory T cells encounter foreign antigen along with proper co-stimulation they undergo rapid and extensive clonal expansion. In mammals, this type of proliferation is fairly unique to cells of the adaptive immune system and requires a considerable expenditure of energy and cellular resources. While research has often focused on the roles of cytokines, antigenic signals, and co-stimulation in guiding T cell responses, data indicate that, at a fundamental level, it is cellular metabolism that regulates T cell function and differentiation and therefore influences the final outcome of the adaptive immune response. This review will focus on some earlier fundamental observations regarding T cell bioenergetics and its role in regulating cellular function, as well as recent work that suggests that manipulating the immune response by targeting lymphocyte metabolism could prove useful in treatments against infection and cancer.

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IL-10 is a potent immunomodulatory cytokine produced by protective immune cell subsets, including Treg cells, and known to play a key role in inducing and maintaining allograft tolerance.
“In accordance with Treg cell expansion during allograft rejection, there was a substantial increase in serum IL-10—a potent immunomodulatory cytokine produced by protective immune cell subsets, including Treg cells, and known to play a key role in inducing and maintaining allograft tolerance45.”
From Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation (2019) · cites this paper as [45]
Regulating energy metabolism may allow T cells to reversibly switch between quiescent and highly proliferative states.
“Regulating energy metabolism may provide a way for T cells to reversibly switch between quiescent and highly proliferative states (12).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [12]
Upon T cell activation, T cells shift from a relatively metabolically quiescent state (primarily catabolic) to a highly metabolic phenotype (primarily anabolic and aerobic glycolysis).
“upon T cell activation, T cells shift from a relatively metabolically quiescent state (characterized primarily by catabolic metabolism) to a highly metabolic phenotype (characterized primarily by anabolic metabolism and the induction of aerobic glycolysis) [106].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [106]
Metabolism is centrally important in regulating T cell function.
“there has been an increasing understanding of the central importance of metabolism in regulating T cell function [5, 106, 107].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [106]

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Self-citation
T‐cell metabolism governing activation, proliferation and differentiation; a modular view
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Authors: Pearce, E. L.
Affiliations: Trudeau Institute (US)
Corresponding author: Pearce, Erika L
ORCID: Pearce, Erika L
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2010-06
Volume: 22
Issue: 3
Pages: 314-320
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2010.01.018
PMC: PMC4486663
OpenAlex: W1970662865
Cited by: 314
References: 82
Citations by year: 2026: 27 · 2025: 25 · 2024: 20 · 2023: 18 · 2022: 17 · 2021: 17 · 2020: 23 · 2019: 20 · 2018: 12 · 2017: 24 · 2016: 15 · 2015: 19 · 2014: 21 · 2013: 24 · 2012: 22
FWCI: 1.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Emerald Foundation
National Cancer Institute (R01CA181125)
National Institute of Allergy and Infectious Diseases (R01AI091965)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: T cell metabolism, T cell activation, T cell differentiation, bioenergetics, clonal expansion, costimulation, memory T cells
MeSH terms: Animals, Cell Differentiation, Glucose, Humans, Lymphocyte Activation, T-Lymphocytes, Lipid Metabolism, Mice

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Metabolism in T cell activation and differentiation

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