The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Homer1a is a core brain molecular correlate of sleep loss
Open accessAbstract
Sleep is regulated by a homeostatic process that determines its need and by a circadian process that determines its timing. By using sleep deprivation and transcriptome profiling in inbred mouse strains, we show that genetic background affects susceptibility to sleep loss at the transcriptional level in a tissue-dependent manner. In the brain, Homer1a expression best reflects the response to sleep loss. Time-course gene expression analysis suggests that 2,032 brain transcripts are under circadian control. However, only 391 remain rhythmic when mice are sleep-deprived at four time points around the clock, suggesting that most diurnal changes in gene transcription are, in fact, sleep–wake-dependent. By generating a transgenic mouse line, we show that in Homer1 -expressing cells specifically, apart from Homer1a , three other activity-induced genes ( Ptgs2 , Jph3 , and Nptx2 ) are overexpressed after sleep loss. All four genes play a role in recovery from glutamate-induced neuronal hyperactivity. The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness.
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Cited by
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“Gene expression studies identified Homer1a as a core gene of sleep loss, as its expression was consistently upregulated in different strains of mice after 6 h of sleep deprivation (771).”
BackgroundControl of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
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The human circadian metabolome
Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114410109 · Cited by 566
Metadata
- Authors
- Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbuchle, O., O'Hara, B. F., Franken, P., & Tafti, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-11
- Volume
- 104
- Issue
- 50
- Pages
- 20090-20095
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085674106
- Cited by
- 368
- References
- 39
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbuchle, O., O'Hara, B. F., Franken, P., & Tafti, M. (2007). Homer1a is a core brain molecular correlate of sleep loss. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0710131104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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