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Cited by 41

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β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins

He, Wanxia, Hu, Jinxuan, Xia, Yuxing, Yan, Riqiang·2014·Journal of Biological Chemistry
DOI 10.1074/jbc.m114.579862
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  • BACE1 regulates Notch3 signaling via direct cleavage of JAG1, in turn, increasing aberrant angiogenesis and vessel sprouting.

    “BACE1 regulates Notch3 signaling via direct cleavage of JAG1, in turn, increasing aberrant angiogenesis and vessel sprouting.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [131]

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Research works printed but not linked: 41

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  2. Yan, 1999, Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity, Nature, 402, 533, 10.1038/990107 · DOI · Paper page
  3. Hussain, 1999, Identification of a novel aspartic protease (Asp 2) as β-secretase, Mol. Cell Neurosci, 14, 419, 10.1006/mcne.1999.0811 · DOI · Paper page
  4. Sinha, 1999, Purification and cloning of amyloid precursor protein β-secretase from human brain, Nature, 402, 537, 10.1038/990114 · DOI · Paper page
  5. Lin, 2000, Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein, Proc. Natl. Acad. Sci. U.S.A, 97, 1456, 10.1073/pnas.97.4.1456 · DOI
  6. Yang, 2003, Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease, Nat. Med, 9, 3, 10.1038/nm0103-3 · DOI · Paper page
  7. Selkoe, 1996, The role of APP processing and trafficking pathways in the formation of amyloid β-protein, Ann. N.Y. Acad. Sci, 777, 57, 10.1111/j.1749-6632.1996.tb34401.x · DOI · Paper page
  8. Cai, 2001, BACE1 is the major β-secretase for generation of Aβ peptides by neurons, Nat. Neurosci, 4, 233, 10.1038/85064 · DOI
  9. Luo, 2001, Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation, Nat. Neurosci, 4, 231, 10.1038/85059 · DOI · Paper page
  10. Roberds, 2001, BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer's disease therapeutics, Hum. Mol. Genet, 10, 1317, 10.1093/hmg/10.12.1317 · DOI · Paper page
  11. Yan, 2001, The transmembrane domain of the Alzheimer's β-secretase (BACE1) determines its late Golgi localization and access to β-amyloid precursor protein (APP) substrate, J. Biol. Chem, 276, 36788, 10.1074/jbc.M104350200 · DOI
  12. Hu, 2006, Bace1 modulates myelination in the central and peripheral nervous system, Nat. Neurosci, 9, 1520, 10.1038/nn1797 · DOI · Paper page
  13. Hu, 2008, Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves, FASEB J, 22, 2970, 10.1096/fj.08-106666 · DOI · Paper page
  14. Kim, 2007, BACE1 regulates voltage-gated sodium channels and neuronal activity, Nat. Cell Biol, 9, 755, 10.1038/ncb1602 · DOI
  15. Cai, 2012, β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment, EMBO Mol. Med, 4, 980, 10.1002/emmm.201101084 · DOI · Paper page
  16. Kuhn, 2012, Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons, EMBO J, 31, 3157, 10.1038/emboj.2012.173 · DOI · Paper page
  17. Hemming, 2009, Identification of β-secretase (BACE1) substrates using quantitative proteomics, PLoS ONE, 4, e8477, 10.1371/journal.pone.0008477 · DOI
  18. Hu, 2013, BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway, Cell Rep, 4, 40, 10.1016/j.celrep.2013.06.005 · DOI · Paper page
  19. Kopan, 2009, The canonical Notch signaling pathway: unfolding the activation mechanism, Cell, 137, 216, 10.1016/j.cell.2009.03.045 · DOI
  20. He, 2004, Reticulon family members modulate BACE1 activity and amyloid-β peptide generation, Nat. Med, 10, 959, 10.1038/nm1088 · DOI
  21. Tomasselli, 2003, Employing a superior BACE1 cleavage sequence to probe cellular APP processing, J. Neurochem, 84, 1006, 10.1046/j.1471-4159.2003.01597.x · DOI
  22. Luo, 2011, Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination, J. Biol. Chem, 286, 23967, 10.1074/jbc.M111.251538 · DOI
  23. Boyer-Di Ponio, 2007, Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling, Hum. Mol. Genet, 16, 2683, 10.1093/hmg/ddm222 · DOI
  24. Parr-Sturgess, 2010, Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event, Biochem. J, 432, 283, 10.1042/BJ20100321 · DOI
  25. Liu, 2002, Glu11 site cleavage and N-terminally truncated Aβ production upon BACE overexpression, Biochemistry, 41, 3128, 10.1021/bi015800g · DOI · Paper page
  26. Qahwash, 2004, Processing amyloid precursor protein at the β-site requires proper orientation to be accessed by BACE1, J. Biol. Chem, 279, 39010, 10.1074/jbc.M407101200 · DOI
  27. Huse, 2002, β-Secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain, J. Biol. Chem, 277, 16278, 10.1074/jbc.M111141200 · DOI · Paper page
  28. Fluhrer, 2002, A non-amyloidogenic function of BACE-2 in the secretory pathway, J. Neurochem, 81, 1011, 10.1046/j.1471-4159.2002.00908.x · DOI · Paper page
  29. Ikeuchi, 2003, The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent “γ-secretase” cleavage, J. Biol. Chem, 278, 7751, 10.1074/jbc.C200711200 · DOI
  30. LaVoie, 2003, The Notch ligands, Jagged and Delta, are sequentially processed by α-secretase and presenilin/γ-secretase and release signaling fragments, J. Biol. Chem, 278, 34427, 10.1074/jbc.M302659200 · DOI
  31. Xue, 1999, Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1, Hum. Mol. Genet, 8, 723, 10.1093/hmg/8.5.723 · DOI
  32. Oda, 1997, Mutations in the human Jagged1 gene are responsible for Alagille syndrome, Nat. Genet, 16, 235, 10.1038/ng0797-235 · DOI
  33. Li, 1997, Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1, Nat. Genet, 16, 243, 10.1038/ng0797-243 · DOI
  34. Yuan, 1998, Mutational analysis of the Jagged 1 gene in Alagille syndrome families, Hum. Mol. Genet, 7, 1363, 10.1093/hmg/7.9.1363 · DOI
  35. Schroeter, 1998, Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain, Nature, 393, 382, 10.1038/30756 · DOI
  36. De Strooper, 1999, A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain, Nature, 398, 518, 10.1038/19083 · DOI · Paper page
  37. Farzan, 2000, BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein, Proc. Natl. Acad. Sci. U.S.A, 97, 9712, 10.1073/pnas.160115697 · DOI · Paper page
  38. Yan, 2001, BACE2 functions as an alternative α-secretase in cells, J. Biol. Chem, 276, 34019, 10.1074/jbc.M105583200 · DOI
  39. Sun, 2006, BACE2, as a novel APP θ-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome, FASEB J, 20, 1369, 10.1096/fj.05-5632com · DOI
  40. Turner, 2002, Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity, Biochemistry, 41, 8742, 10.1021/bi025926t · DOI
  41. Grüninger-Leitch, 2002, Substrate and inhibitor profile of BACE (β-secretase) and comparison with other mammalian aspartic proteases, J. Biol. Chem, 277, 4687, 10.1074/jbc.M109266200 · DOI · Paper page

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Metadata

Authors
He, W., Hu, J., Xia, Y., & Yan, R.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2014-07
Volume
289
Issue
30
Pages
20630-20637
ISSN
0021-9258
DOI
10.1074/jbc.m114.579862
Cited by
41
References
3
Language
en
Licence
Funders
National Institutes of Health (AG025493, AG046929, NS074256)

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