BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes

Bonifacino, J. S., & Traub, L. M. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161800 · Cited by 2,040 · see citing works

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612 · see citing works

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature · doi:10.1038/990107 · Cited by 1,438 · see citing works

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,430 · see citing works

Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling

Mukhopadhyay, D., & Riezman, H. (2007) · Science · doi:10.1126/science.1127085 · Cited by 1,221 · see citing works

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001 · see citing works

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Cai, H., Wang, Y.-S., McCarthy, D., Wen, H., Borchelt, D., Price, D. L., & Wong, P. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 791 · see citing works

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Lin, H., Koelsch, G., Lin, X., Wu, S., Terzyan, S. S., Ghosh, A. K., Zhang, X. C., & Tang, J. (2000) · Science · doi:10.1126/science.290.5489.150 · Cited by 711 · see citing works

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer’s disease therapeutics

Roberds, S. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1317 · Cited by 705 · see citing works

Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C. (2006) · Science · doi:10.1126/science.1132341 · Cited by 703 · see citing works

The endocytic pathway: a mosaic of domains

Gruenberg, J. E. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096054 · Cited by 703 · see citing works

Bace1 modulates myelination in the central and peripheral nervous system

Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience · doi:10.1038/nn1797 · Cited by 608 · see citing works

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3657-09.2009 · Cited by 577 · see citing works

Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain

Huang, F., Kirkpatrick, D. S., Jiang, X., Gygi, S. P., & Sorkin, A. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.018 · Cited by 553 · see citing works

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R., & Disterhoft, J. F. (2004) · Neuron · doi:10.1016/s0896-6273(03)00810-9 · Cited by 549 · see citing works

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

Bache, K. G., Brech, A., Mehlum, A., & Stenmark, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302131 · Cited by 470 · see citing works

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455 · see citing works

Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme

Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M.-Y., & Doms, R. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004175200 · Cited by 402 · see citing works

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

Longva, K. E., Blystad, F. D., Stang, E., Larsen, A. M., Johannessen, L. E., & Madshus, I. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200106056 · Cited by 385 · see citing works

Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.012 · Cited by 337 · see citing works

STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes

Bache, K. G., Raiborg, C., Mehlum, A., & Stenmark, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210843200 · Cited by 324 · see citing works

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

Lu, Q., Hope, L. W., Brasch, M. A., Reinhard, C., & Cohen, S. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932599100 · Cited by 319 · see citing works

Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice

McConlogue, L., Buttini, M., Anderson, J. P., Brigham, E. F., Chen, K. S., Freedman, S. B., Games, D., Johnson-Wood, K., Lee, M., Zeller, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611687200 · Cited by 300 · see citing works

Temporal memory deficits in Alzheimer’s mouse models: Rescue by genetic deletion of BACE1

Ohno, M., Chang, L., Tseng, W., Oakley, H., Citron, M., Klein, W. L., Vassar, R., & Disterhoft, J. F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04551.x · Cited by 298 · see citing works

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in <i>BACE1</i> -null mice

Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., & Wong, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710373105 · Cited by 290 · see citing works

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

Ohno, M., Cole, S. L., Yasvoina, M., Zhao, J., Citron, M., Berry, R., Disterhoft, J. F., & Vassar, R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.008 · Cited by 290 · see citing works

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

Lauwers, E., Jacob, C., & André, B. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810114 · Cited by 275 · see citing works

Phosphorylation Regulates Intracellular Trafficking of β-Secretase

Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G., & Haass, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011116200 · Cited by 272 · see citing works

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

Bishop, N. E., Horman, A., & Woodman, P. G. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112080 · Cited by 266 · see citing works

Reticulon family members modulate BACE1 activity and amyloid-β peptide generation

He, W., Lu, Y., Qahwash, I. M., Hu, X., Chang, A., & Yan, R. (2004) · Nature Medicine · doi:10.1038/nm1088 · Cited by 257 · see citing works

The ubiquitin code of yeast permease trafficking

Lauwers, E., Erpapazoglou, Z., Haguenauer‐Tsapis, R., & André, B. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.004 · Cited by 245 · see citing works

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

Sannerud, R., Declerck, I., Peric, A., Raemaekers, T., Menéndez, G., Zhou, L., Baert, V., Coen, K., Munck, S., Strooper, B. D., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100745108 · Cited by 239 · see citing works

Interactions of GGA3 with the ubiquitin sorting machinery

Puertollano, R., & Bonifacino, J. S. (2004) · Nature Cell Biology · doi:10.1038/ncb1106 · Cited by 231 · see citing works

GGA Proteins Mediate the Recycling Pathway of Memapsin 2 (BACE)

He, X., Li, F., Chang, W., & Tang, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411296200 · Cited by 225 · see citing works

Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family

Creemers, J. W. M., Dominguez, D. I., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, K., Annaert, W. G., & Strooper, B. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006947200 · Cited by 187 · see citing works

VHS domains of ESCRT‐0 cooperate in high‐avidity binding to polyubiquitinated cargo

Ren, X., & Hurley, J. H. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.6 · Cited by 186 · see citing works

GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network

Scott, P. M., Bilodeau, P. S., Zhdankina, O., Winistorfer, S. C., Hauglund, M. J., Allaman, M. M., Kearney, W. R., Robertson, A. D., Boman, A. L., & Piper, R. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1107 · Cited by 173 · see citing works

BACE Is Degraded via the Lysosomal Pathway

Koh, Y. H., Arnim, C. A. F. V., Hyman, B. T., Tanzi, R. E., & Tesco, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506199200 · Cited by 166 · see citing works

Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes

Piper, R. C., & Luzio, J. P. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.07.002 · Cited by 161 · see citing works

An automated method to quantify and visualize colocalized fluorescent signals

Jaskolski, F., Mulle, C., & Manzoni, O. J. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.01.012 · Cited by 148 · see citing works

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

Wahle, T., Prager, K., Raffler, N., Haass, C., Famulok, M., & Walter, J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.014 · Cited by 131 · see citing works

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.

Liu, K., Doms, R., & Lee, V. (2002) · Biochemistry · doi:10.1021/bi015800g · Cited by 128 · see citing works

The Carboxyl-Terminus of BACE Contains a Sorting Signal That Regulates BACE Trafficking but Not the Formation of Total Aβ

Pastorino, L., Ikin, A. F., Nairn, A. C., Pursnani, A. K., & Buxbaum, J. D. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1065 · Cited by 111 · see citing works

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

Kang, E. L., Cameron, A. N., Piazza, F., Walker, K. R., & Tesco, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092742 · Cited by 111 · see citing works

Demonstration of BACE (β-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

Arnim, C. A. F. V., Tangredi, M. M., Peltan, I. D., Lee, B. M., Irizarry, M. C., Kinoshita, A., & Hyman, B. T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01422 · Cited by 107 · see citing works

Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

Pak, Y., Glowacka, W. K., Bruce, M. C., Pham, N., & Rotin, D. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603001 · Cited by 104 · see citing works

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

Sankaranarayanan, S., Price, E. A., Wu, G., Crouthamel, M., Shi, X., Tugusheva, K., Tyler, K. X., Kahana, J. A., Ellis, J. D., Jin, L., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.130039 · Cited by 101 · see citing works

Biochemical and Structural Characterization of the Interaction of Memapsin 2 (β-Secretase) Cytosolic Domain with the VHS Domain of GGA Proteins

He, X., Zhu, G., Koelsch, G., Rodgers, K. K., Zhang, X. C., & Tang, J. (2003) · Biochemistry · doi:10.1021/bi035199h · Cited by 80 · see citing works

Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, γ-ear-containing, ADP-ribosylation-factor-binding proteins

Prag, G., Lee, S., Mattera, R., Arighi, C. N., Beach, B. M., Bonifacino, J. S., & Hurley, J. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500118102 · Cited by 70 · see citing works

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

Prabhu, Y., Burgos, P. V., Schindler, C., Farías, G. G., Magadán, J. G., & Bonifacino, J. S. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0944 · Cited by 68 · see citing works

Insights into the Phosphoregulation of β‐Secretase Sorting Signal by the VHS Domain of GGA1

Shiba, T., Kametaka, S., Kawasaki, M., Shibata, M., Waguri, S., Uchiyama, Y., & Soichi Wakatsuki, A. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00188.x · Cited by 68 · see citing works

The GAT Domains of Clathrin-associated GGA Proteins Have Two Ubiquitin Binding Motifs

Bilodeau, P. S., Winistorfer, S. C., Allaman, M. M., Surendhran, K., Kearney, W. R., Robertson, A. D., & Piper, R. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406654200 · Cited by 59 · see citing works

Membrane Protein Targeting to the MVB/Lysosome

Davies, B. A., Lee, J. R. E., Oestreich, A. J., & Katzmann, D. J. (2009) · Chemical Reviews · doi:10.1021/cr800473s · Cited by 55 · see citing works

Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.

Deng, Y., Guo, Y., Watson, H., Au, W.-C., Shakoury-Elizeh, M., Basrai, M. A., Bonifacino, J. S., & Philpott, C. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030015 · Cited by 41 · see citing works

Molecular mechanism of ubiquitin recognition by GGA3 GAT domain

Kawasaki, M., Shiba, T., Shiba, Y., Yamaguchi, Y., Matsugaki, N., Igarashi, N., Suzuki, M., Kato, R., Kato, K., Nakayama, K., et al. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00865.x · Cited by 41 · see citing works

The Endocytic Pathway

Conibear, E., & Tam, Y. (2009) · Springer eBooks · doi:10.1007/978-0-387-93877-6_4 · Cited by 35 · see citing works

Retromer Regulates Postendocytic Sorting of β‐Secretase in Polarized Madin–Darby Canine Kidney Cells

Cuartero, Y., Mellado-López, M., Capell, A., Álvarez‐Dolado, M., & Vergés, M. (2012) · Traffic · doi:10.1111/j.1600-0854.2012.01392.x · Cited by 13 · see citing works

The β-Secretase BACE1 in Alzheimer’s Disease

Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.001 · Cited by 694 · see citing works

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Vassar, R. J., Kuhn, P., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12715 · Cited by 329 · see citing works

In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease

Park, H., Oh, J., Shim, G., Cho, B., Chang, Y., Kim, S., Baek, S., Kim, H., Shin, J., Choi, H. G., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0352-0 · Cited by 274 · see citing works

Angiotensin II Mediates Angiotensin Converting Enzyme Type 2 Internalization and Degradation Through an Angiotensin II Type I Receptor–Dependent Mechanism

Deshotels, M. R., Xia, H., Sriramula, S., Lazartigues, E. D., & Filipeanu, C. M. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03743 · Cited by 264 · see citing works

Dysregulation of protein trafficking in neurodegeneration

Wang, X., Huang, T. Y., Bu, G., & Xu, H. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-31 · Cited by 124 · see citing works

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology

Koelsch, G. (2017) · Molecules · doi:10.3390/molecules22101723 · Cited by 125 · see citing works

G Protein-Coupled Receptors (GPCRs) in Alzheimer’s Disease: A Focus on BACE1 Related GPCRs

Zhao, J., Deng, Y., Jiang, Z., & Qing, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00058 · Cited by 108 · see citing works

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Mateus, A., Gordon, L. J., Wayne, G. J., Almqvist, H., Axelsson, H., Seashore-Ludlow, B. A., Treyer, A., Matsson, P., Lundbäck, T., West, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701848114 · Cited by 106 · see citing works

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

Yan, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00097 · Cited by 105 · see citing works

Antioxidant, anti-diabetic, acetylcholinesterase inhibitory potential and estimation of alkaloids (lycorine and galanthamine) from Crinum species: An important source of anticancer and anti-Alzheimer drug

Ghane, S. G., Attar, U. A., Yadav, P. B., & Lekhak, M. M. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.08.087 · Cited by 99 · see citing works

Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases

Liu, B., Ruan, J., Chen, M., Li, Z., Manjengwa, G. M., Schlüter, D., Song, W., & Wang, X. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01233-8 · Cited by 103 · see citing works

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

Miyagawa, T., Ebinuma, I., Morohashi, Y., Hori, Y., Young Chang, M., Hattori, H., Maehara, T., Yokoshima, S., Fukuyama, T., Tsuji, S., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw146 · Cited by 95 · see citing works

The N-Terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH through a Gain of Function Mechanism

Brännström, K., Öhman, A., Nilsson, L., Pihl, M., Sandblad, L., & Olofsson, A. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503535m · Cited by 74 · see citing works

The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation

Yeates, E. F. A., & Tesco, G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.718023 · Cited by 74 · see citing works

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

Zheng, Q., Song, B., Li, G., Cai, F., Wu, M., Zhao, Y., Jiang, L., Guo, T., Shen, M., Hou, H., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci152170 · Cited by 73 · see citing works

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease

Yan, R., Fan, Q., Zhou, J., & Vassar, R. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.025 · Cited by 71 · see citing works

Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation

Feng, T., Tammineni, P., Agrawal, C., Jeong, Y. Y., & Cai, Q. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.766584 · Cited by 69 · see citing works

Role of Post‐translational Modifications in Alzheimer's Disease

Ramesh, M., Gopinath, P., & Govindaraju, T. (2019) · ChemBioChem · doi:10.1002/cbic.201900573 · Cited by 68 · see citing works

Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease

Ye, X., Feng, T., Tammineni, P., Chang, Q., Jeong, Y. Y., Margolis, D. J., Cai, H., Kusnecov, A. W., & Cai, Q. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2851-16.2017 · Cited by 62 · see citing works

Snapin-Mediated BACE1 Retrograde Transport Is Essential for Its Degradation in Lysosomes and Regulation of APP Processing in Neurons

Ye, X., & Cai, Q. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.008 · Cited by 63 · see citing works

BACE1 as a Therapeutic Target in Alzheimer’s Disease: Rationale and Current Status

Evin, G. M., & Hince, C. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0099-3 · Cited by 60 · see citing works

AP‐2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons

Bera, S., Camblor‐Perujo, S., Barca, E. C., Negrete‐Hurtado, A., Racho, J., Bruyckere, E. D., Wittich, C., Ellrich, N., Martins, S., Adjaye, J., et al. (2020) · EMBO Reports · doi:10.15252/embr.201947954 · Cited by 55 · see citing works

In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications

Huang, K. L., Zapata, D. A., Tang, Y., Teng, Y., & Li, Y. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121876 · Cited by 55 · see citing works

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease

Bao, J., Qin, M., Mahaman, Y. A. R., Zhang, B., Huang, F., Zeng, K., Xia, Y., Ke, D., Wang, Q., Liu, R., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800498115 · Cited by 50 · see citing works

DUBs in Alzheimer’s disease: mechanisms and therapeutic implications

Qin, B., Chen, X., Wang, F., & Wang, Y. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02237-3 · Cited by 33 · see citing works

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Kim, W., Ma, L., Lomoio, S., Willen, R., Lombardo, S., Dong, J., Haydon, P. G., & Tesco, G. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0239-7 · Cited by 32 · see citing works

Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice

Fan, Y., Guo, T., Han, X., Liu, J.-L., Cai, Y.-T., Han, X., Huang, X., Li, Y., Wang, Z., & Guo, C. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.014 · Cited by 27 · see citing works

Post-Translational Modifications of BACE1 in Alzheimer's Disease

Wen, W., Li, P., Liu, P., Xu, S., Wang, F., & Huang, J. H. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210121163224 · Cited by 30 · see citing works

Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage

Williamson, R., Laulagnier, K., Miranda, A. M., Fernandez, M. A., Wolfe, M. S., Sadoul, R., & Paolo, G. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.818138 · Cited by 28 · see citing works

Post-translational regulation of the β-secretase BACE1

Araki, W. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.009 · Cited by 28 · see citing works

Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research

Yuan, M., Wang, Y., Huang, Z., Jing, F., Qiao, P., Zou, Q., Li, J., & Cai, Z. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220145 · Cited by 25 · see citing works

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1

Lu, M., Ji, W., Xu, D.-E., Yao, P.-P., Zhao, X., Wang, Z., Fang, L., Huang, R., Lan, L.-J., Chen, J.-B., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.09.012 · Cited by 25 · see citing works

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Kurkinen, K. M. A., Marttinen, M., Turner, L. J., Natunen, T., Mäkinen, P. M., Haapalinna, F., Sarajärvi, T., Gabbouj, S., Kurki, M., Paananen, J., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.185215 · Cited by 21 · see citing works

The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer’s Disease

Shah, H., Patel, A. D., Parikh, V., Nagani, A., Bhimani, B., Shah, U., & Bambharoliya, T. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200526144141 · Cited by 20 · see citing works

Zinc and phosphorus fertilization in Galanthus elwesii Hook: Changes in the total alkaloid, flavonoid, and phenolic content, and evaluation of anti-cancer, anti-microbial, and antioxidant activities

Ay, E. B., Açıkgöz, M. A., Kocaman, B., Mesci̇, S., Kocaman, B., & Yıldırım, T. (2023) · Scientia Horticulturae · doi:10.1016/j.scienta.2023.112034 · Cited by 20 · see citing works

The Effects of Foliar Salicylic Acid and Zinc Treatments on Proline, Carotenoid, and Chlorophyll Content and Anti-Oxidant Enzyme Activity in Galanthus elwesii Hook

Kırgeç, Y., Ay, E. B., & Açıkgöz, M. A. (2023) · Horticulturae · doi:10.3390/horticulturae9091041 · Cited by 16 · see citing works

The Involvement of Post-Translational Modifications in Regulating the Development and Progression of Alzheimer’s Disease

Guan, P.-P., & Wang, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03277-z · Cited by 15 · see citing works

Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer’s disease models

Yi, L., Luo, M., Wang, M., Dong, Z., & Du, Y.-H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1288506 · Cited by 14 · see citing works

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Ulku, I., Liebsch, F., Åkerman, S., Schulz, J. F., Kulic, L., Höck, C., Pietrzik, C. U., Spiezio, A. D., Thinakaran, G., Säftig, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-28846-z · Cited by 14 · see citing works

Retromer in Polarized Protein Transport

Vergés, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2015.12.005 · Cited by 13 · see citing works

BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology

Zhao, Y., Zhou, H., Zhao, Y., Liang, Z., Gong, X., Yu, J. H., Huang, T., Yang, C., Wu, M., Xiao, Y., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15870 · Cited by 13 · see citing works

The hidden players: Shedding light on the significance of post-translational modifications and miRNAs in Alzheimer's disease development

Singh, R. J., Hussain, J., Kaur, A., Jamdare, B. G., Pathak, D., Garg, K., Kaur, R., Shankar, S., & Sunkaria, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102002 · Cited by 13 · see citing works

pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo

Zhao, L., Zhao, Y., Tang, F., Xiong, L., Su, C., Mei, L., Zhu, X., & Xiong, W. (2019) · Cells · doi:10.3390/cells8050474 · Cited by 13 · see citing works

Vectors in CRISPR Gene Editing for Neurological Disorders: Challenges and Opportunities

Xiong, K., Wang, X., Feng, C., Zhang, K., Chen, D., & Yang, S. (2025) · Advanced Biology · doi:10.1002/adbi.202400374 · Cited by 12 · see citing works

Effect of jasmonic and salicylic acids foliar spray on the galanthamine and lycorine content and biological characteristics in Galanthus elwesii Hook

Ay, E. B., Açıkgöz, M. A., Kocaman, B., & Güler, S. K. (2023) · Phytochemistry Letters · doi:10.1016/j.phytol.2023.08.010 · Cited by 10 · see citing works

The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage

Gaborit, B., Govers, R., Altié, A., Brunel, J. M., Morange, P., & Peiretti, F. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100818 · Cited by 9 · see citing works

Effect of phosphorus fertilization on phenolic compounds and antioxidant activity in Galanthus elwesii Hook.

Ay, E. B., Şevket Metin, K. A. R. A., & Açıkgöz, M. A. (2023) · International Journal of Agriculture Environment and Food Sciences · doi:10.31015/jaefs.2023.3.22 · Cited by 4 · see citing works

HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease

Lee, J., Cho, Y., Choi, B. Y., Kim, H. K., Lee, Y., Kim, E., Han, J., Sul, J. H., Kim, J. S., Baek, S. H., et al. (2026) · Brain · doi:10.1093/brain/awag089 · Cited by 4 · see citing works

A GFP-tagged version of the pseudorabies virus protein UL56 localizes to the Golgi and trans-Golgi network through a predicted C-terminal leucine-rich helix in transfected cells

Lyu, C., & Cai, X. (2019) · Virology Journal · doi:10.1186/s12985-019-1191-z · Cited by 3 · see citing works

Decoding the secretase puzzle in amyloid-β generation: A state-of-the-art overview of the protease-mediated APP processing cascade in Alzheimer’s disease

Senkowska, Z., & Węglarz‐Tomczak, E. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103116 · Cited by 2 · see citing works

BACE1 Inhibitors: Attractive Therapeutics for Alzheimer’s Disease

Decourt, B., Macias, M. P., Sabbagh, M., & Adem, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50010-6

Alpha-synuclein expression influences the processing of the amyloid precursor protein

Hall‐Roberts, H. (2016) · The University of Bath Online Publications Store (The University of Bath)

The effect of the combination of erythromycin with new beta-lactam antibiotics against gram-negative aerobic respiratory pathogens.

Nakatomi, M., & Neu, H. C. (1986) · PubMed

Genetic and functional studies of genes involved in the pathogenesis of Alzheimer's disease

Natunen, T. (2014) · UEF eRepo (University of Eastern Finland)

Molecular mechanisms of action of MT-MMPs involved in the pathogenesis of Alzheimer’s disease

García‐González, L. (2020) · theses.fr (ABES) · doi:10.70675/a04672c0z1f4az472ezbcd5zbea446eac50c

BACE Is Degraded via the Lysosomal Pathway

Koh, Y. H., Arnim, C. A. F. V., Hyman, B. T., Tanzi, R. E., & Tesco, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506199200 · Cited by 166 · see citing works

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

Prabhu, Y., Burgos, P. V., Schindler, C., Farías, G. G., Magadán, J. G., & Bonifacino, J. S. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0944 · Cited by 68 · see citing works

The Carboxyl-Terminus of BACE Contains a Sorting Signal That Regulates BACE Trafficking but Not the Formation of Total Aβ

Pastorino, L., Ikin, A. F., Nairn, A. C., Pursnani, A. K., & Buxbaum, J. D. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1065 · Cited by 111 · see citing works

Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme

Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M.-Y., & Doms, R. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004175200 · Cited by 402 · see citing works

Flotillins bind to the dileucine sorting motif of β‐site amyloid precursor protein‐cleaving enzyme 1 and influence its endosomal sorting

John, B. A., Meister, M., Banning, A., & Tikkanen, R. (2014) · FEBS Journal · doi:10.1111/febs.12763 · Cited by 31 · see citing works