The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A biodegradable and biocompatible gecko-inspired tissue adhesive
Open accessAbstract
There is a significant medical need for tough biodegradable polymer adhesives that can adapt to or recover from various mechanical deformations while remaining strongly attached to the underlying tissue. We approached this problem by using a polymer poly(glycerol-co-sebacate acrylate) and modifying the surface to mimic the nanotopography of gecko feet, which allows attachment to vertical surfaces. Translation of existing gecko-inspired adhesives for medical applications is complex, as multiple parameters must be optimized, including: biocompatibility, biodegradation, strong adhesive tissue bonding, as well as compliance and conformability to tissue surfaces. Ideally these adhesives would also have the ability to deliver drugs or growth factors to promote healing. As a first demonstration, we have created a gecko-inspired tissue adhesive from a biocompatible and biodegradable elastomer combined with a thin tissue-reactive biocompatible surface coating. Tissue adhesion was optimized by varying dimensions of the nanoscale pillars, including the ratio of tip diameter to pitch and the ratio of tip diameter to base diameter. Coating these nanomolded pillars of biodegradable elastomers with a thin layer of oxidized dextran significantly increased the interfacial adhesion strength on porcine intestine tissue in vitro and in the rat abdominal subfascial in vivo environment. This gecko-inspired medical adhesive may have potential applications for sealing wounds and for replacement or augmentation of sutures or staples.
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Cites
Adhesive force of a single gecko foot-hair
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A reversible wet/dry adhesive inspired by mussels and geckos
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Evidence for van der Waals adhesion in gecko setae
Autumn, K., Sitti, M., Liang, Y. A., Peattie, A. M., Hansen, W. R., Sponberg, S., Kenny, T. W., Fearing, R., Israelachvili, J. N., & Full, R. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192252799 · Cited by 1,949
Microfabricated adhesive mimicking gecko foot-hair
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A tough biodegradable elastomer
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Self-citationMultifunctional chondroitin sulphate for cartilage tissue–biomaterial integration
Wang, D.-A., Varghese, S., Sharma, B., Strehin, I., Fermanian, S., Gorham, J., Fairbrother, D. H., Cascio, B., & Elisseeff, J. H. (2007) · Nature Materials · doi:10.1038/nmat1890 · Cited by 693
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Frictional adhesion: a new angle on gecko attachment
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Evidence for self-cleaning in gecko setae
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Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material
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Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes
Pyron, R., Burbrink, F. T., & Wiens, J. J. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-93 · Cited by 1,641
Engineering Substrate Topography at the Micro‐ and Nanoscale to Control Cell Function
Bettinger, C. J., Langer, R., & Borenstein, J. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805179 · Cited by 1,258
Self-citationBiological materials: Functional adaptations and bioinspired designs
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Metadata
- Authors
- Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J. W., Chan, E. P., Carter, D. J. D., Bettinger, C. J., Patanavanich, S., Chignozha, L., Ben-Joseph, E., Galakatos, A., Pryor, H., Pomerantseva, I., Masiakos, P. T., Faquin, W., Zumbuehl, A., Hong, S., Borenstein, J., Vacanti, J., Langer, R., & Karp, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-02-19
- Volume
- 105
- Issue
- 7
- Pages
- 2307-2312
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017948987
- Cited by
- 554
- References
- 19
- FWCI
- 34.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J. W., Chan, E. P., Carter, D. J. D., Bettinger, C. J., Patanavanich, S., Chignozha, L., Ben-Joseph, E., Galakatos, A., Pryor, H., Pomerantseva, I., Masiakos, P. T., Faquin, W., Zumbuehl, A., Hong, S., Borenstein, J., Vacanti, J., . . . Karp, J. M. (2008). A biodegradable and biocompatible gecko-inspired tissue adhesive. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0712117105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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