Cited by 119Neural dynamics and brain functionNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Successful choice behavior is associated with distinct and coherent network states in anterior cingulate cortex

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Lapish, Christopher C., Durstewitz, Daniel, Chandler, L. Judson, Seamans, Jeremy K.·2008·Proceedings of the National Academy of Sciences

Abstract

Successful decision making requires an ability to monitor contexts, actions, and outcomes. The anterior cingulate cortex (ACC) is thought to be critical for these functions, monitoring and guiding decisions especially in challenging situations involving conflict and errors. A number of different single-unit correlates have been observed in the ACC that reflect the diverse cognitive components involved. Yet how ACC neurons function as an integrated network is poorly understood. Here we show, using advanced population analysis of multiple single-unit recordings from the rat ACC during performance of an ecologically valid decision-making task, that ensembles of neurons move through different coherent and dissociable states as the cognitive requirements of the task change. This organization into distinct network patterns with respect to both firing-rate changes and correlations among units broke down during trials with numerous behavioral errors, especially at choice points of the task. These results point to an underlying functional organization into cell assemblies in the ACC that may monitor choices, outcomes, and task contexts, thus tracking the animal's progression through “task space.”

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Crossref · 10.1073/pnas.0804045105

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  • The activity of neurons varied substantially in different trial epochs (99% of neurons, 675/681, ANOVA p<0.05).

    “Consistent with previous studies23-25, we found that the activity of neurons varied substantially in different trial epochs (99% of neurons, 675/681, ANOVA p<0.05).”

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Authors
Lapish, C. C., Durstewitz, D., Chandler, L. J., & Seamans, J. K.
Affiliations
  • University of British Columbia (CA)
  • University of Plymouth (GB)
  • Medical University of South Carolina (US)
Venue
Proceedings of the National Academy of Sciences
Published
2008-08-19
Volume
105
Issue
33
Pages
11963-11968
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2032434570
Cited by
119
References
47
Citations by year
2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 8
FWCI
3.62
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Canadian Institutes of Health Research (84319_1)
  • National Institute on Alcohol Abuse and Alcoholism (R01AA010983, R29AA010983, AA 10983)
  • National Institute of Mental Health (MH065924, R01MH065924, MH064569, R01MH064569)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
anterior cingulate cortex, decision-making, choice behavior, neuronal ensembles, cell assemblies, single-unit activity, behavioral errors, task space, rats
MeSH terms
Animals, Behavior, Animal, Brain, Choice Behavior, Decision Making, Electrophysiology, Male, Nerve Net, Neural Pathways, Neurons, Rats, Long-Evans, Rats

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