Cited by 95Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeural dynamics and brain function

Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex

Gonzalez-Burgos, G., Kroener, S., Zaitsev, A. V., Povysheva, N. V., Krimer, L. S., Barrionuevo, G., Lewis, D. A.·2008·Cerebral Cortex

Abstract

In the primate dorsolateral prefrontal cortex (DLPFC), the density of excitatory synapses decreases by 40-50% during adolescence. Although such substantial circuit refinement might underlie the adolescence-related maturation of working memory performance, its functional significance remains poorly understood. The consequences of synaptic pruning may depend on the properties of the eliminated synapses. Are the synapses eliminated during adolescence functionally immature, as is the case during early brain development? Or do maturation-independent features tag synapses for pruning? We examined excitatory synaptic function in monkey DLPFC during postnatal development by studying properties that reflect synapse maturation in rat cortex. In 3-month-old (early postnatal) monkeys, excitatory inputs to layer 3 pyramidal neurons had immature properties, including higher release probability, lower alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/N-methyl-D-aspartate (NMDA) ratio, and longer duration of NMDA-mediated synaptic currents, associated with greater sensitivity to the NMDA receptor subunit B (NR2B) subunit-selective antagonist ifenprodil. In contrast, excitatory synaptic inputs in neurons from preadolescent (15 months old) and adult (42 or 84 months old) monkeys had similar functional properties. We therefore conclude that the contribution of functionally immature synapses decreases significantly before adolescence begins. Thus, remodeling of excitatory connectivity in the DLPFC during adolescence may occur in the absence of widespread maturational changes in synaptic strength.

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Crossref · 10.1093/cercor/bhm095

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  • Functional measures of excitatory AMPA and NMDA mediated currents in frontal cortex pyramidal neurons do not change between the juvenile and adolescent periods in macaques or mice.

    “Functional measures of excitatory AMPA and NMDA mediated currents in frontal cortex pyramidal neurons do not change between the juvenile and adolescent periods in macaques or mice (Gonzalez-Burgos et al., 2008; Vandenberg et al., 2015)”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Gonzalez-Burgos et al., 2008

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Authors
Gonzalez-Burgos, G., Kroener, S., Zaitsev, A. V., Povysheva, N. V., Krimer, L. S., Barrionuevo, G., & Lewis, D. A.
Affiliations
  • Medical University of South Carolina (US)
  • University of Pittsburgh (US)
Venue
Cerebral Cortex
Published
2007-06-24
Volume
18
Issue
3
Pages
626-637
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2102786824
Cited by
95
References
86
Citations by year
2026: 7 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 9
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH 45156, P50MH045156)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
excitatory synapses, synapse maturation, dorsolateral prefrontal cortex, postnatal development, adolescence, synaptic pruning, AMPA/NMDA ratio, NMDA receptor, NR2B subunit, ifenprodil, release probability, primate brain development
MeSH terms
Animals, Animals, Newborn, Female, Macaca mulatta, Primates, Synapses, Prefrontal Cortex, Pyramidal Cells, Excitatory Postsynaptic Potentials, Dendritic Spines

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