The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity
Open accessAbstract
Pro- and mature neurotrophins often elicit opposing biological effects. For example, mature brain-derived neurotrophic factor (mBDNF) is critical for long-term potentiation induced by high-frequency stimulation, whereas proBDNF facilitate long-term depression induced by low-frequency stimulation. Because mBDNF is derived from proBDNF by endoproteolytic cleavage, mechanisms regulating the cleavage of proBDNF may control the direction of BDNF regulation. Using methods that selectively detect proBDNF or mBDNF, we show that low-frequency stimulation induced predominant proBDNF secretion in cultured hippocampal neurons. In contrast, high-frequency stimulation preferentially increased extracellular mBDNF. Inhibition of extracellular, but not intracellular cleavage of proBDNF greatly reduced high-frequency stimulation-induced extracellular mBDNF. Moreover, high-frequency, but not low-frequency stimulation selectively induced the secretion of tissue plasminogen activator, a key protease involved in extracellular proBDNF to mBDNF conversion. Thus, high-frequency neuronal activity controls the ratio of extracellular proBDNF/mBDNF by regulating the secretion of extracellular proteases. Our study demonstrates activity-dependent control of extracellular proteolytic cleavage of a secretory protein, and reveals an important mechanism that controls diametrically opposed functions of BDNF isoforms.
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Cites
Regulation of Cell Survival by Secreted Proneurotrophins
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Self-citationNEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337
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Self-citationProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013
Self-citationRequirement for BDNF in activity-dependent survival of cortical neurons
Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994) · Science · doi:10.1126/science.7907431 · Cited by 989
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Self-citationPeng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03135.x · Cited by 691
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Cited by
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., Cohen, L. G., & Lu, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.035 · Cited by 1,420
Self-citationBDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043
Self-citationNew Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function
Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3566-09.2009 · Cited by 597
Self-citationBDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425
Metadata
- Authors
- Nagappan, G., Zaitsev, E., Senatorov, V. V., Yang, J., Hempstead, B. L., & Lu, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-01-27
- Volume
- 106
- Issue
- 4
- Pages
- 1267-1272
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049692154
- Cited by
- 270
- References
- 10
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Nagappan, G., Zaitsev, E., Senatorov, V. V., Yang, J., Hempstead, B. L., & Lu, B. (2009). Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0807322106
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