CTCF-dependent enhancer-blocking by alternative chromatin loop formation

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Capturing Chromosome Conformation

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The Transcriptional Integrator CREB-Binding Protein Mediates Positive Cross Talk between Nuclear Hormone Receptors and the Hematopoietic bZip Protein p45/NF-E2

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HS5 of the human β‐globin locus control region: a developmental stage‐specific border in erythroid cells

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Formation of chromosomal domains by loop extrusion

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CTCF: Master Weaver of the Genome

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Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

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Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

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Bioinformatics and Drug Discovery

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Genetic and Epigenetic Regulation of PD-1 Expression

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Finding distal regulatory elements in the human genome

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An Overview of Genome Organization and How We Got There: from FISH to Hi-C

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Identification of the elementary structural units of the DNA damage response

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Genomics of Long-Range Regulatory Elements

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CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ Locus

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CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates

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PD-1 regulation in immune homeostasis and immunotherapy

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The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading

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Differential contribution of cis -regulatory elements to higher order chromatin structure and expression of the CFTR locus

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CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation

Plasschaert, R. N., Vigneau, S., Tempera, I., Gupta, R., Maksimoska, J., Everett, L. J., Davuluri, R. V., Mamorstein, R., Lieberman, P. M., Schultz, D., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt910 · Cited by 60 · see citing works

3D genome organization in health and disease: emerging opportunities in cancer translational medicine

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Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells

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CTCF mediates the TERT enhancer-promoter interactions in lung cancer cells: Identification of a novel enhancer region involved in the regulation of TERT gene

Eldholm, V., Haugen, A., & Zienolddiny, S. (2013) · International Journal of Cancer · doi:10.1002/ijc.28570 · Cited by 56 · see citing works

Three-dimensional organization and dynamics of the genome

Szałaj, P., & Plewczyński, D. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9428-y · Cited by 54 · see citing works

The tumor suppressor role of CTCF

Fiorentino, F. P., & Giordano, A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22780 · Cited by 53 · see citing works

Germline Deletion of Igh 3′ Regulatory Region Elements hs 5, 6, 7 (hs5–7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus

Volpi, S. A., Verma‐Gaur, J., Hassan, R., Ju, Z., Roa, S., Chatterjee, S., Werling, U., Hou, H., Will, B., Steidl, U. G., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102763 · Cited by 52 · see citing works

High-throughput Pore-C reveals the single-allele topology and cell type-specificity of 3D genome folding

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The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes

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Alteration of genome folding via contact domain boundary insertion

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Comparative characterization of 3D chromatin organization in triple-negative breast cancers

Kim, T., Han, S., Chun, Y., Yang, H.-J., Min, H., Jeon, S. Y., Kim, J., Moon, H., & Lee, D. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00768-2 · Cited by 47 · see citing works

Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding

Alhashem, Y. N., Vinjamur, D. S., Basu, M., Klingmüller, U., Gaensler, K. M. L., & Lloyd, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.247536 · Cited by 46 · see citing works

Homologue Pairing in Flies and Mammals: Gene Regulation When Two Are Involved

Apte, M. S., & Meller, V. H. (2011) · Genetics Research International · doi:10.1155/2012/430587 · Cited by 44 · see citing works

The CTCF insulator protein forms an unusual DNA structure

MacPherson, M. J., & Sadowski, P. D. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-101 · Cited by 46 · see citing works

Effective Blocking of the White Enhancer Requires Cooperation between Two Main Mechanisms Suggested for the Insulator Function

Kyrchanova, O., Maksimenko, O. G., Stakhov, V., Ivlieva, T., Parshikov, A., Studitsky, V. M., & Georgiev, P. G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003606 · Cited by 45 · see citing works

The Determinants of Directionality in Transcriptional Initiation

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Enhancer-promoter interactions and transcription are maintained upon acute loss of CTCF, cohesin, WAPL, and YY1

Hsieh, T.-H. S., Cattoglio, C., Slobodyanyuk, E., Hansen, A. S., Darzacq, X., & Tjian, R. (2021) · doi:10.1101/2021.07.14.452365 · Cited by 42 · see citing works

Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing

Horvath, L. M., Li, N., & Carrel, L. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003952 · Cited by 40 · see citing works

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus

Junier, I., Dale, R., Hou, C., Képès, F., & Dean, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks536 · Cited by 38 · see citing works

Identifying and Characterizing Regulatory Sequences in the Human Genome with Chromatin Accessibility Assays

Sheffield, N. C., & Furey, T. S. (2012) · Genes · doi:10.3390/genes3040651 · Cited by 37 · see citing works

Targeting CTCF to Control Virus Gene Expression: A Common Theme amongst Diverse DNA Viruses

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Transcriptional and epigenetic regulation of PD-1 expression

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Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human β-globin Gene Cluster

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Close encounters of the 3C kind: long-range chromatin interactions and transcriptional regulation

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Systematic identification of protein combinations mediating chromatin looping

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A systematic description of MLL fusion gene formation

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Genomic Locations of Conserved Noncoding Sequences and Their Proximal Protein-Coding Genes in Mammalian Expression Dynamics

Babarinde, I. A., & Saitou, N. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw058 · Cited by 30 · see citing works

The Human IL-3/Granulocyte-Macrophage Colony-Stimulating Factor Locus Is Epigenetically Silent in Immature Thymocytes and Is Progressively Activated during T Cell Development

Mirabella, F., Baxter, E. W., Boissinot, M., James, S. R., & Cockerill, P. N. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901364 · Cited by 34 · see citing works

Insights about genome function from spatial organization of the genome

Roy, S. S., Mukherjee, A. K., & Chowdhury, S. (2018) · Human Genomics · doi:10.1186/s40246-018-0140-z · Cited by 32 · see citing works

Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci

Loguercio, S., Barajas-Mora, E. M., Shih, H., Krangel, M. S., & Feeney, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00425 · Cited by 32 · see citing works

The impact of histone post-translational modifications on developmental gene regulation

Cruickshank, M. N., Besant, P. G., & Ulgiati, D. (2010) · Amino Acids · doi:10.1007/s00726-010-0530-6 · Cited by 33 · see citing works

Epigenomic analysis of Alzheimer's disease brains reveals diminished CTCF binding on genes involved in synaptic organization

Patel, P. J., Ren, Y., & Yan, Z. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106192 · Cited by 32 · see citing works

DNA-binding factor CTCF and long-range gene interactions in V(D)J recombination and oncogene activation

de Almeida, C. R., Stadhouders, R., Thongjuea, S., Soler, É., & Hendriks, R. W. (2012) · Blood · doi:10.1182/blood-2012-03-402586 · Cited by 31 · see citing works

Throwing transcription for a loop: expression of the genome in the 3D nucleus

Hou, C., & Corces, V. G. (2011) · Chromosoma · doi:10.1007/s00412-011-0352-7 · Cited by 30 · see citing works

Three additional de novo CTCF mutations in Chinese patients help to define an emerging neurodevelopmental disorder

Chen, F., Yuan, H., Wu, W., Chen, S., Yang, Q., Wang, J., Zhang, Q., Gui, B., Fan, X., Chen, R., et al. (2019) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31698 · Cited by 31 · see citing works

Regulation and Dysregulation of Chromosome Structure in Cancer

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Bridging chromatin structure and function over a range of experimental spatial and temporal scales by molecular modeling

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Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity

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Three-dimensional chromatin architecture in plants – General features and novelties

Tourdot, É., & Grob, S. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151344 · Cited by 29 · see citing works

CTCF blocks antisense transcription initiation at divergent promoters

Luan, J. Y., Vermunt, M. W., Syrett, C. M., Coté, A., Tome, J. M., Zhang, H., Huang, A., Luppino, J. M., Keller, C. A., Giardine, B. M., et al. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00855-y · Cited by 29 · see citing works

Many facades of CTCF unified by its coding for three-dimensional genome architecture

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The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders

Chambers, C. B., Gross, J., Pratt, K. L., Guo, X., Byrnes, C., Lee, Y. T., Lavelle, D., Dean, A., Miller, J. L., & Wilber, A. C. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.01.011 · Cited by 27 · see citing works

CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions

Zhou, R., Tian, K., Huang, J. S., Duan, W., Fu, H., Feng, Y., Wang, H., Jiang, Y., Li, Y., Wang, R., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105011 · Cited by 26 · see citing works

Bioinformatics Analysis of the Factors Controlling Type I IFN Gene Expression in Autoimmune Disease and Virus-Induced Immunity

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B Cell Differentiation Is Associated with Reprogramming the CCCTC Binding Factor–Dependent Chromatin Architecture of the Murine MHC Class II Locus

Majumder, P., Scharer, C. D., Choi, N. M., & Boss, J. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303205 · Cited by 27 · see citing works

Noncoding RNAs and the borders of heterochromatin

Cohen, A. L., & Jia, S. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1249 · Cited by 26 · see citing works

Osmotic mechanism of the loop extrusion process.

Yamamoto, T., & Schiessel, H. (2017) · Physical Review E · doi:10.1103/physreve.96.030402 · Cited by 20 · see citing works

CTCF, Cohesin, and Chromatin in Human Cancer

Song, S., & Kim, T. (2017) · Genomics & Informatics · doi:10.5808/gi.2017.15.4.114 · Cited by 24 · see citing works

A tour of 3D genome with a focus on CTCF

Wang, D. C., Wang, W. Y., Zhang, L., & Wang, X. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.020 · Cited by 24 · see citing works

Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function

Schoborg, T. A., & Labrador, M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1672-6 · Cited by 21 · see citing works

Chromatin structure of the LCR in the human β-globin locus transcribing the adult δ- and β-globin genes

Kim, S., Kim, Y. W., Shim, S. H., Kim, C. G., & Kim, A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.12.001 · Cited by 22 · see citing works

Manipulating nuclear architecture

Deng, W., & Blobel, G. A. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.10.014 · Cited by 23 · see citing works

Human β-Globin Locus Control Region HS5Contains CTCF- and Developmental Stage-Dependent Enhancer-BlockingActivity in ErythroidCells

Tanimoto, K., Sugiura, A., Omori, A., Felsenfeld, G., Engel, J. D., & Fukamizu, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.8946-8952.2003 · Cited by 55 · see citing works

Enhancer Blocking by Chicken β-Globin 5′-HS4

Zhao, H., Kim, A., Song, S., & Dean, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606803200 · Cited by 20 · see citing works

Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci

Farrell, C. M., West, A. G., & Felsenfeld, G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3820-3831.2002 · Cited by 184 · see citing works

Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

Targa, F. R., Pikaart, M. J., Burgess-Beusse, B. L., Bell, A. C., Litt, M. D., West, A. G., Gaszner, M., & Felsenfeld, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102179399 · Cited by 381 · see citing works

Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

Li, Q., & Stamatoyannopoulos, G. (1994) · Blood · doi:10.1182/blood.v84.5.1399.1399 · Cited by 111 · see citing works