Cited by 384Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and DisordersMitochondrial Function and Pathology

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

Open access
Kayo, Tsuyoshi, Allison, David B., Weindruch, Richard, Prolla, Tomas A.·2001·Proceedings of the National Academy of Sciences

Abstract

In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We have previously used high-density oligonucleotide arrays to show that CR can prevent or delay most of the major age-related transcriptional alterations in the gastrocnemius muscle of C57BL/6 mice. Here we report the effects of aging and adult-onset CR on the gene expression profile of 7,070 genes in the vastus lateralis muscle from rhesus monkeys. Gene expression analysis of aged rhesus monkeys (mean age of 26 years) was compared with that of young animals (mean age of 8 years). Aging resulted in a selective up-regulation of transcripts involved in inflammation and oxidative stress, and a down-regulation of genes involved in mitochondrial electron transport and oxidative phosphorylation. Middle-aged monkeys (mean age of 20 years) subjected to CR since early adulthood (mean age of 11 years) were studied to determine the gene expression profile induced by CR. CR resulted in an up-regulation of cytoskeletal protein-encoding genes, and also a decrease in the expression of genes involved in mitochondrial bioenergetics. Surprisingly, we did not observe any evidence for an inhibitory effect of adult-onset CR on age-related changes in gene expression. These results indicate that the induction of an oxidative stress-induced transcriptional response may be a common feature of aging in skeletal muscle of rodents and primates, but the extent to which CR modifies these responses may be species-specific.

Integrity signals

Registry

Crossref · 10.1073/pnas.081061898

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kayo, T., Allison, D. B., Weindruch, R., & Prolla, T. A.
Affiliations
St. Luke's-Roosevelt Hospital Center (US)
Corresponding author
Weindruch, Richard
Venue
Proceedings of the National Academy of Sciences
Published
2001-04-17
Volume
98
Issue
9
Pages
5093-5098
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2073151196
Cited by
384
References
26
Citations by year
2026: 3 · 2025: 1 · 2024: 7 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 19
FWCI
11.31
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG 11915, P01AG011915)
  • National Cancer Institute (R01 CA 78732)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
caloric restriction, aging, skeletal muscle, gene expression profiles, rhesus monkeys, oxidative stress, inflammation, mitochondrial electron transport chain, oxidative phosphorylation, cytoskeletal proteins, mitochondrial bioenergetics, species differences, gastrocnemius, vastus lateralis
MeSH terms
Aging, Animals, Energy Intake, Electron Transport, Food Deprivation, Humans, Macaca mulatta, Male, Oxidative Phosphorylation, RNA, Messenger, Transcription, Genetic, Down-Regulation, Up-Regulation, Oxidative Stress, Muscle, Skeletal, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review