A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys
Open accessAbstract
Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan in many species, including nonhuman primates, although the effect on the brain is less well characterized. We used two common indicators of aging, motor performance speed and brain iron deposition measured in vivo using magnetic resonance imaging, to determine the potential effect of CR on elderly rhesus macaques eating restricted (n= 24, 13 males, 11 females) and standard (n= 17, 8 males, 9 females) diets. Both the CR and control monkeys showed age-related increases in iron concentrations in globus pallidus (GP) and substantia nigra (SN), although the CR group had significantly less iron deposition in the GP, SN, red nucleus, and temporal cortex. A Diet × Age interaction revealed that CR modified age-related brain changes, evidenced as attenuation in the rate of iron accumulation in basal ganglia and parietal, temporal, and perirhinal cortex. Additionally, control monkeys had significantly slower fine motor performance on the Movement Assessment Panel, which was negatively correlated with iron accumulation in left SN and parietal lobe, although CR animals did not show this relationship. Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species.
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Functional neuroimaging results showed that caloric restriction in older monkeys reduced iron deposition in the brain and improved motor performance on multiple measures.
“In a separate study, functional neuroimaging results showed that caloric restriction in older monkeys reduced iron deposition in the brain and improved motor performance on multiple measures (Kastman et al, 2012).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Kastman et al, 2012
A longitudinal study on aging in Rhesus monkeys showed exacerbated brain volume loss and stress reactivity (as indicated by increased hostility, resistance, and fear response) in response to social stress.
“A longitudinal study on aging in Rhesus monkeys showed exacerbated brain volume loss and stress reactivity (as indicated by increased hostility, resistance, and fear response) in response to social stress (Kastman et al, 2012).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Kastman et al, 2012
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- Authors
- Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L., Voytko, M. L., Beasley, T. M., Colman, R. J., Weindruch, R. H., & Johnson, S. C.
- Affiliations
- University of Wisconsin–Madison (US)
- Wake Forest University Health Sciences (US)
- University of Alabama at Birmingham (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-08-22
- Volume
- 32
- Issue
- 34
- Pages
- 11897-11904
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W4236586118
- Cited by
- 40
- References
- 79
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (RR000167, AG11915, AG000213)
- National Institute on Aging (P01-AG-11915, AG-000213, R01AG043125, P01AG011915, T32AG000213)
- National Center for Research Resources (C06RR020141, RR 15459-01, C06RR015459, RR 020141-01, P51RR000167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- caloric restriction, brain iron accumulation, aging, rhesus monkeys, motor performance, globus pallidus, substantia nigra, basal ganglia, red nucleus, temporal cortex, neuroprotection, lifespan extension
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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