The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Altered sexual and social behaviors in trp2 mutant mice
Open accessAbstract
We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the electrophysiological response to pheromones in the VNO, suggesting that trp2 plays a central role in mediating the pheromone response. These mutants therefore afford the opportunity to examine the role of the VNO in the generation of innate sexual and social behaviors in mice. Trp2 mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Male–female sexual behavior appears normal, but trp2 mutant males also vigorously mount other males. These results suggest that the cation channel trp2 is required in the VNO to detect male-specific pheromones that elicit aggressive behaviors and dictate the choice of sexual partners.
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Cited by
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Metadata
- Authors
- Leypold, B. G., Yu, C. R., Leinders-Zufall, T., Kim, M. M., Zufall, F., & Axel, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-23
- Volume
- 99
- Issue
- 9
- Pages
- 6376-6381
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2124674257
- Cited by
- 567
- References
- 36
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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