The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
Open accessAbstract
Patients with sepsis have a marked defect in neutrophil migration. Here we identify a key role of Toll-like receptor 2 (TLR2) in the regulation of neutrophil migration and resistance during polymicrobial sepsis. We found that the expression of the chemokine receptor CXCR2 was dramatically down-regulated in circulating neutrophils from WT mice with severe sepsis, which correlates with reduced chemotaxis to CXCL2 in vitro and impaired migration into an infectious focus in vivo. TLR2 deficiency prevented the down-regulation of CXCR2 and failure of neutrophil migration. Moreover, TLR2 −/− mice exhibited higher bacterial clearance, lower serum inflammatory cytokines, and improved survival rate during severe sepsis compared with WT mice. In vitro, the TLR2 agonist lipoteichoic acid (LTA) down-regulated CXCR2 expression and markedly inhibited the neutrophil chemotaxis and actin polymerization induced by CXCL2. Moreover, neutrophils activated ex vivo by LTA and adoptively transferred into naïve WT recipient mice displayed a significantly reduced competence to migrate toward thioglycolate-induced peritonitis. Finally, LTA enhanced the expression of G protein–coupled receptor kinases 2 (GRK2) in neutrophils; increased expression of GRK2 was seen in blood neutrophils from WT mice, but not TLR2 −/− mice, with severe sepsis. Our findings identify an unexpected detrimental role of TLR2 in polymicrobial sepsis and suggest that inhibition of TLR2 signaling may improve survival from sepsis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Microglia have been shown to be capable of phagocytosis of amyloid fibrils (2)”
From CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-β Phagocytosis (2010) · cites this paper as [2]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Akira, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300028200 · Cited by 1,499
Sepsis and septic shock—A review of laboratory models and a proposal
Wichterman, K. A., Baue, A. E., & Chaudry, I. H. (1980) · Journal of Surgical Research · doi:10.1016/0022-4804(80)90037-2 · Cited by 1,466
G PROTEIN–COUPLED RECEPTOR KINASES
Pitcher, J. A., Freedman, N. J., & Lefkowitz, R. J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.653 · Cited by 1,370
Takeuchi, O., Hoshino, K., & Akira, S. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.10.5392 · Cited by 1,156
Chemokines and chemokine receptors in leukocyte trafficking
Olson, T. S., & Ley, K. F. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00738.2001 · Cited by 670
Neutrophils in development of multiple organ failure in sepsis
Brown, K., Brain, S. D., Pearson, J. D., Edgeworth, J. D., Sm, L., & Treacher, D. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69005-3 · Cited by 652
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils
Kobayashi, S. D., Braughton, K. R., Whitney, A. R., Voyich, J. M., Schwan, T. G., Musser, J. M., & DeLeo, F. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1833375100 · Cited by 336
Cited by
Sorted by citations
The Neutrophil’s Role During Health and Disease
Liew, P. X., & Kubes, P. (2019) · Physiological Reviews · doi:10.1152/physrev.00012.2018 · Cited by 1,237
The immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 888
The neutrophil in vascular inflammation
Phillipson, M., & Kubes, P. (2011) · Nature Medicine · doi:10.1038/nm.2514 · Cited by 788
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.894886 · Cited by 684
Self-citationSepsis-induced immune dysfunction: can immune therapies reduce mortality?
Delano, M. J., & Ward, P. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82224 · Cited by 676
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection
Alves-Filho, J. C., Sônego, F., Souto, F. O., de Freitas, A., Verri, W. A., Jr., Auxiliadora‐Martins, M., Basile-Filho, A., McKenzie, A. N. J., Xu, D., Cunha, F. Q., et al. (2010) · Nature Medicine · doi:10.1038/nm.2156 · Cited by 485
Self-citationNeutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis
Zhang, H., Wang, Y., Qu, M., Li, W., Wu, D., Cata, J. P., & Miao, C. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1170 · Cited by 442
Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis
Czaikoski, P. G., Mota, J. M., Nascimento, D. C., Sônego, F., Castanheira, F. V. S., Melo, P. H., Scortegagna, G. T., Silva, R. L., Barroso‐Sousa, R., Souto, F. O., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148142 · Cited by 414
Self-citationPotential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
Cheng, Y., Ma, X., Wei, Y.-Q., & Wei, X. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.01.005 · Cited by 352
Neutrophil dysregulation during sepsis: an overview and update
Shen, X., Cao, K., Jiang, J., Guan, W., & Du, J. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13112 · Cited by 346
The function of neutrophils in sepsis
Kovach, M. A., & Standiford, T. J. (2012) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3283528c9b · Cited by 289
Liu, Z., Condello, C., Schain, A., Harb, R., & Grutzendler, J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4403-10.2010 · Cited by 275
“Furthermore, crosstalk can occur between chemokine and pattern recognition receptor signaling pathways leading to functional changes in phagocytes (Kishore et al., 2005; Alves-Filho et al., 2009).”
BackgroundNeutrophil diversity and function in health and disease
Zhang, F., Xia, Y., Su, J., Quan, F., Zhou, H., Li, Q., Feng, Q., Lin, C., Wang, D., & Jiang, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02049-y · Cited by 306
Petri, B., & Sanz, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2776-8 · Cited by 260
Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious
Sônego, F., Castanheira, F. V. S., Ferreira, R. G., Kanashiro, A., Leite, C. A., Nascimento, D. C., Colón, D. F., Borges, V. D. F., Alves-Filho, J. C., & Cunha, F. Q. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00155 · Cited by 239
Self-citationNEUTROPHIL PARALYSIS IN SEPSIS
Alves-Filho, J. C., Spiller, F., & Cunha, F. Q. (2010) · Shock · doi:10.1097/shk.0b013e3181e7e61b · Cited by 233
Self-citationEnhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects against Sepsis
Kong, X., Thimmulappa, R. K., Craciun, F. L., Harvey, C. J., Singh, A., Kombairaju, P., Reddy, S. P., Remick, D. G., & Biswal, S. S. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201102-0271oc · Cited by 223
Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis
Souto, F. O., Alves-Filho, J. C., Turato, W. M., Auxiliadora‐Martins, M., Basile-Filho, A., & Cunha, F. Q. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0416oc · Cited by 183
Self-citationNeutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Colón, D. F., Wanderley, C. W. S., Franchin, M., Silva, C. M. S., Hiroki, C. H., Castanheira, F. V. S., Donate, P. B., Lopes, A. H., Volpon, L. C., Kavaguti, S. K., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2407-8 · Cited by 171
Self-citationSepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection
Delano, M. J., Thayer, T. C., Gabrilovich, S., Kelly‐Scumpia, K. M., Winfield, R. D., Scumpia, P. O., Cuenca, A. G., Warner, E., Wallet, S. M., Wallet, M. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002104 · Cited by 165
Dowey, R., Iqbal, A., Heller, S. R., Sabroe, I., & Prince, L. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678771 · Cited by 144
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients
Pontelli, M. C., Castro, Í. A., Júnior, R. B. M., Serra, L. L., Veras, F. P., Nascimento, D. C., Silva, C. M. S., Cardoso, R. D. S., Rosales, R., Gomes, R., et al. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac021 · Cited by 141
Self-citationCastoldi, Â., Braga, T. T., Corrêa-Costa, M., de Aguiar, C. F., Bassi, Ê. J., Correa-Silva, R., Elias, R. M., Salvador, F. A., Moraes‐Vieira, P. M., Cenedeze, M. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037584 · Cited by 144
Wang, J., Li, J., Zhao, Y.-J., Yi, W., Bian, J., Wan, X., Zhu, K., & Deng, X. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000525 · Cited by 124
The role of Nox2-derived ROS in the development of cognitive impairment after sepsis
Hernandes, M. S., d’Avila, J. C., Trevelin, S. C., Reis, P. A., Kinjo, É. R., Lopes, L. R., Castro-Faria-Neto, H. C., Cunha, F. Q., Britto, L. R. G., & Bozza, F. A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-36 · Cited by 129
Self-citationTrevelin, S. C., Carlos, D., Beretta, M., Silva, J. S., & Cunha, F. Q. (2016) · Shock · doi:10.1097/shk.0000000000000778 · Cited by 123
Self-citationNeutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection
Hiroki, C. H., Toller-Kawahisa, J. E., Fumagalli, M. J., Colón, D. F., Figueiredo, L. T. M., Fonseca, B. A. L. D., França, R. F. D. O., & Cunha, F. Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03108 · Cited by 118
Self-citationTargeting nitric oxide as a key modulator of sepsis, arthritis and pain
Spiller, F., Formiga, R. D. O., Coimbra, J. F. D. S., Alves-Filho, J. C., Cunha, T. M., & Cunha, F. Q. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.04.011 · Cited by 115
Self-citationNeutrophil Migration Under Normal and Sepsis Conditions
Lerman, Y. V., & Kim, M. (2015) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x15666150108113236 · Cited by 116
Mechanisms regulating chemokine receptor activity
Bennett, L. D., Fox, J. M., & Signoret, N. Y. M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03485.x · Cited by 112
Regulation of innate immune responses by transmembrane interactions: Lessons from the TLR family
Reuven, E. M., Fink, A., & Shai, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.01.020 · Cited by 113
Talbot, J., Bianchini, F. J., Dcb., N., de Oliveira, R. D. R., Souto, F. O., Pinto, L. G., Peres, R. S., Silva, D., Almeida, S. C. L., Louzada‐Júnior, P., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39117 · Cited by 109
Self-citationThe function of TLR2 during staphylococcal diseases
Fournier, B. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00167 · Cited by 113
Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K+ATP Channel Activation
Spiller, F., Orrico, M. I. L., Nascimento, D. C., Czaikoski, P. G., Souto, F. O., Alves-Filho, J. C., de Freitas, A., Carlos, D., Montenegro, M. F., Neto, A. F., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1145oc · Cited by 107
Self-citationLiew, F. Y. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200589 · Cited by 101
Frutuoso, M. S., Hori, J. I., Pereira, M. S. F., Lima-Junior, D. S., Sônego, F., Kobayashi, K. S., Flavell, R. A., Cunha, F. Q., & Zamboni, D. S. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.05.006 · Cited by 100
Self-citationMicroparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis
Dalli, J., Norling, L. V., Montero‐Melendez, T., Canova, D. F., Lashin, H., Pavlov, A. M., Sukhorukov, G. B., Hinds, C., & Perretti, M. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201303503 · Cited by 100
Effects of sepsis on neutrophil chemotaxis
Reddy, R. C., & Standiford, T. J. (2009) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32833338f3 · Cited by 96
Yao, R.-Q., Ren, C., Wang, J., Wu, G., Zhu, X., Xia, Z., & Yao, Y.-M. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37496 · Cited by 95
Özdemir, S., Altun, S., & Arslan, H. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.12.019 · Cited by 93
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis*
Zou, L., Feng, Y., Chen, Y.-J., Si, R., Shen, S., Zhou, Q., Ichinose, F., Scherrer‐Crosbie, M., & Chao, W. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181d99e67 · Cited by 88
Blood Purification in Sepsis: A New Paradigm
Peng, Z., Singbartl, K., Simon, P., Rimmele, T. R., Bishop, J. V., Clermont, G., & Kellum, J. A. (2010) · Contributions to nephrology · doi:10.1159/000313773 · Cited by 88
Neutrophils and Intravascular Immunity in the Liver during Infection and Sterile Inflammation
McDonald, B., & Kubes, P. (2011) · Toxicologic Pathology · doi:10.1177/0192623311427570 · Cited by 89
Le, H. T., Tran, V. G., Kim, W., Kim, J., Cho, H. R., & Kwon, B. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103564 · Cited by 90
Cellular and molecular choreography of neutrophil recruitment to sites of sterile inflammation
McDonald, B., & Kubes, P. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0784-9 · Cited by 93
Luo, S., Liao, C., Zhang, L., Ling, C., Zhang, X., Xie, P., Su, G., Chen, Z., Zhang, L., Lai, T., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112259 · Cited by 86
Hu, M., Wang, C., Li, W., Lu, W., Bai, Z., Qin, D., Yan, Q., Zhu, J., Krueger, B. J., Renne, R., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005171 · Cited by 84
Liu, Y., Song, R., Zhao, L., Lu, Z., Li, Y., Zhan, X., Lu, F., Yang, J., Niu, Y., & Cao, X. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01020-z · Cited by 84
Innate Immune Deficiency of Extremely Premature Neonates Can Be Reversed by Interferon-γ
Tissières, P., Ochoda, A., Dunn-Siegrist, I., Drifte, G., Morales, M. A., Pfister, R. E., Berner, M. E., & Pugin, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032863 · Cited by 84
Aziz, M., Matsuda, A., Yang, W.-L., Jacob, A., & Wang, P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200262 · Cited by 82
Zou, L., Feng, Y., Li, Y., Zhang, M., Chen, C., Cai, J., Gong, Y., Wang, L. L., Thurman, J. M., Wu, X., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301903 · Cited by 79
PPAR-γ/IL-10 Axis Inhibits MyD88 Expression and Ameliorates Murine Polymicrobial Sepsis
Ferreira, A. E., Sisti, F., Sônego, F., Wang, S., Filgueiras, L. R., Brandt, S. L., Serezani, A. P. M., Du, H., Cunha, F. Q., Alves-Filho, J. C., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302375 · Cited by 82
Self-citationDistinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica
Hertwig, L., Pache, F. C., Romero‐Suárez, S., Stürner, K. H., Borisow, N., Behrens, J. R., Bellmann–Strobl, J., Seeger, B., Asselborn, N., Ruprecht, K., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515586084 · Cited by 77
Spiller, F., Carlos, D., Souto, F. O., de Freitas, A., Soares, F. S., Vieira, S. M., de Paula, F. J. A., Alves-Filho, J. C., & Cunha, F. Q. (2012) · Diabetes · doi:10.2337/db11-0825 · Cited by 79
Self-citationToll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis*
Gao, M., Ha, T., Zhang, X., Liu, L., Wang, X., Kelley, J., Singh, K., Kao, R. L., Gao, X., Williams, D. L., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182535aeb · Cited by 73
Wu, Z., Sawamura, T., Kurdowska, A., Ji, H.-L., Idell, S., & Fu, J. (2011) · Infection and Immunity · doi:10.1128/iai.01317-10 · Cited by 74
Hoerr, V., Zbytnuik, L. D., Léger, C., Tam, P., Kubes, P., & Vogel, H. J. (2012) · Journal of Proteome Research · doi:10.1021/pr201274r · Cited by 72
Mikami, A., Ogita, T., Namai, F., Shigemori, S., Sato, T., & Shimosato, T. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.610946 · Cited by 72
Andrade, E. B., Alves, J., Madureira, P., Oliveira, L., Ribeiro, A., Cordeiro‐da‐Silva, A., Correia‐Neves, M., Trieu‐Cuot, P., & Ferreira, P. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301752 · Cited by 72
Neutrophil Paralysis in Plasmodium vivax Malaria
Leoratti, F. M. S., Trevelin, S. C., Cunha, F. Q., Rocha, B. C., Costa, P. A. C., Gravina, H. D., Tada, M. S., Pereira, D. B., Golenbock, D. T., Antonelli, L. R. D. V., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001710 · Cited by 68
Self-citationPeng, Z.-Y., Bishop, J. V., Wen, X., Elder, M. M., Zhou, F., Chuasuwan, A., Carter, M. J., Devlin, J. E., Kaynar, A. M., Singbartl, K., et al. (2014) · Critical Care · doi:10.1186/cc13969 · Cited by 66
Martin, E. L., Souza, D. G., Fagundes, C. T., Amaral, F. A., Assenzio, B., Puntorieri, V., Sorbo, L. D., Fanelli, V., Bosco, M., Delsedime, L., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0088oc · Cited by 66
Self-citationTherapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis
Kanashiro, A., Sônego, F., Ferreira, R. G., Castanheira, F. V. S., Leite, C. A., Borges, V. F., Nascimento, D. C., Colón, D. F., Alves-Filho, J. C., Ulloa, L., et al. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.014 · Cited by 72
Self-citationMishra, H. K., Ma, J., & Walcheck, B. K. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00138 · Cited by 66
Lerman, Y. V., Lim, K., Hyun, Y., Falkner, K. L., Yang, H., Pietropaoli, A. P., Sonnenberg, A., Sarangi, P. P., & Kim, M. (2014) · Blood · doi:10.1182/blood-2014-01-552943 · Cited by 63
Lima, C. X., Souza, D. G., Amaral, F. A., Fagundes, C. T., Rodrigues, I. P. S., Alves-Filho, J. C., Kosco‐Vilbois, M. H., Ferlin, W. G., Shang, L., Elson, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132336 · Cited by 62
Self-citationSkin tape sampling technique identifies proinflammatory cytokines in atopic dermatitis skin
Lyubchenko, T. A., Collins, H. K., Goleva, E., & Leung, D. Y. M. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.08.397 · Cited by 59
Juneja, D., Singh, O., Javeri, Y., & Garg, N. (2010) · Critical Care · doi:10.1186/cc9139 · Cited by 57
Extracellular Vesicles: A Double-Edged Sword in Sepsis
Burgelman, M., Vandendriessche, C., & Vandenbroucke, R. E. (2021) · Pharmaceuticals · doi:10.3390/ph14080829 · Cited by 57
Namas, R. A., Namas, R. A., Lagoa, C., Barclay, D. A., Mi, Q., Zamora, R., Peng, Z., Wen, X., Fedorchak, M. V., Valenti, I. E., et al. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00106 · Cited by 56
IL-33 promotes Staphylococcus aureus-infected wound healing in mice
Yin, H., Li, X., Hu, S., Liu, T., Yuan, B., Ni, Q., Lan, F., Luo, X., Gu, H., & Zheng, F. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.07.008 · Cited by 56
Study of the Helicobacter pylori infection in Iranian patients with multiple sclerosis
Sanadgol, N. (2010) · Critical Care · doi:10.1186/cc9143 · Cited by 56
Korhonen, J. T., Lahesmaa, R., & Puolakkainen, M. H. (2010) · Critical Care · doi:10.1186/cc9141 · Cited by 56
Rodríguez, T. V., Moalli, F., Polentarutti, N., Paroni, M., Bonavita, E., Anselmo, A., Nebuloni, M., Mantero, S., Jaillon, S., Bragonzi, A., et al. (2011) · Infection and Immunity · doi:10.1128/iai.05695-11 · Cited by 54
Feng, Y., Zou, L., Zhang, M., Li, Y., Chen, C., & Chao, W. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31822a22f7 · Cited by 54
da Mota, N. V. F., Brunialti, M. K. C., Santos, S. S., Machado, F. R., de Assunção, M. S. C., Azevedo, L. C. P., & Salomão, R. (2017) · Shock · doi:10.1097/shk.0000000000001078 · Cited by 52
Lajqi, T., Köstlin‐Gille, N., Hillmer, S., Braun, M., Kranig, S. A., Dietz, S., Krause, C., Rühle, J., Frommhold, D., Pöschl, J. M. B., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10020442 · Cited by 53
Souto, F. O., Zarpelon, A. C., Staurengo‐Ferrari, L., Fattori, V., Casagrande, R., Fonseca, M. J. V., Cunha, T. M., Ferreira, S. H., Cunha, F. Q., & Verri, W. A., Jr. (2011) · Journal of Natural Products · doi:10.1021/np1003017 · Cited by 50
Self-citationApocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state
Trevelin, S. C., dos Santos, C. X., Ferreira, R. G., de Sá Lima, L., Silva, R. L., Scavone, C., Curi, R., Alves-Filho, J. C., Cunha, T. M., Roxo-Júnior, P., et al. (2016) · Scientific Reports · doi:10.1038/srep34581 · Cited by 48
Self-citationNew Roles for Innate Immune Response in Acute and Chronic Kidney Injuries
Gonçalves, G. M., Castoldi, Â., Braga, T. T., & Câmara, N. O. S. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02523.x · Cited by 48
Complement as a Major Inducer of Harmful Events in Infectious Sepsis
Fattahi, F., Zetoune, F. S., & Ward, P. A. (2020) · Shock · doi:10.1097/shk.0000000000001531 · Cited by 48
Chen, K., Liu, M., Liu, Y., Wang, C., Yoshimura, T., Gong, W., Le, Y., Tessarollo, L., & Wang, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.450635 · Cited by 47
Patial, S., Saini, Y., Parvataneni, S., Appledorn, D. M., Dorn, G. W., LaPres, J. J., Amalfitano, A., Senagore, P. K., & Parameswaran, N. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22384 · Cited by 46
Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice
Spiller, F., Costa, C., Souto, F. O., Vinchi, F., Mestriner, F. L. A. C., Laure, H. J., Alves-Filho, J. C., Freitas, A., Rosa, J. C., Ferreira, S. H., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0223oc · Cited by 44
Self-citationRicci, E., Ronchetti, S., Pericolini, E., Gabrielli, E., Cari, L., Gentili, M., Roselletti, E., Migliorati, G., Vecchiarelli, A., & Riccardi, C. (2017) · The FASEB Journal · doi:10.1096/fj.201601315r · Cited by 44
Xie, S., Wu, Q., Xu, M., Chen, L., Zhang, M., Yun, X., Wenke, S., Wu, H., Xiao-feng, Z., Chen, S., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.266 · Cited by 43
Pino-Yanes, M. D. M., Corrales, A., Casula, M., Blanco, J., Muriel, A., Espinosa, E., Bello, M. Á. G., Torres, A., Ferrer, M., Zavala, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013759 · Cited by 43
Lan, F., Yuan, B., Liu, T., Luo, X., Huang, P., Liu, Y., Dai, L., & Yin, H. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.03.004 · Cited by 42
Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome*
Trevelin, S. C., Alves-Filho, J. C., Sônego, F., Turato, W. M., Nascimento, D. C., Souto, F. O., Cunha, T. M., Gazzinelli, R. T., & Cunha, F. Q. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318258fb70 · Cited by 42
Self-citationLe, H. T., Kim, W., Kim, J., Cho, H. R., & Kwon, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00104 · Cited by 42
Tan, C., Gu, J. L., Chen, H., Li, T., Deng, H., Liu, K., Liu, M., Tan, S., Xiao, Z., Zhang, H., et al. (2019) · Shock · doi:10.1097/shk.0000000000001334 · Cited by 41
The new sepsis marker, sCD14-ST, induction mechanism in the rabbit sepsis models
Shirakawa, K., Naitou, K., Hirose, J., Nakamura, M., Takeuchi, T., Hosaka, Y., & Furusako, S. (2010) · Critical Care · doi:10.1186/cc9122 · Cited by 41
Soares, F. S., AMARAL, F. C., Silva, N. L. C., Valente, M. R., Santos, L. K. R., Yamashiro, L. H., Scheffer, M. C., Castanheira, F. V. S., Ferreira, R. G., Gehrke, L., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01890 · Cited by 40
Self-citationToya, S. P., Struyf, S., Huerta, L. E., Morris, P. E., Gavioli, E. M., Minnella, E. M., Cesta, M. C., Allegretti, M., & Proost, P. (2024) · European Respiratory Review · doi:10.1183/16000617.0172-2023 · Cited by 41
G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling
Steury, M. D., McCabe, L. R., & Parameswaran, N. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.05.003 · Cited by 39
Pattern recognition receptors as therapeutic targets for bacterial, viral and fungal sepsis
Yuki, K., & Koutsogiannaki, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107909 · Cited by 43
Bruserud, Ø., Mosevoll, K. A., Bruserud, Ø., Reikvam, H., & Wendelbo, Ø. (2023) · Cells · doi:10.3390/cells12071003 · Cited by 38
Pruett, S. B., Fan, R., Cheng, B., Glover, M. C., Tan, W. H., & Deng, X. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq215 · Cited by 38
Targeting neutrophils in sepsis
Sônego, F., Alves-Filho, J. C., & Cunha, F. Q. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.922876 · Cited by 37
Self-citation
Metadata
- Authors
- Alves-Filho, J. C., Freitas, A., Souto, F. O., Spiller, F., Paula-Neto, H., Silva, J. S., Gazzinelli, R. T., Teixeira, M. M., Ferreira, S. H., & Cunha, F. Q.
- Affiliations
- Department of Pharmacology and
- Universidade do Estado do Rio de Janeiro (BR)
- Department of Immunology, School of Medicine of Ribeirão Preto, University of Säo Paulo, 14049–900 Ribeirão Preto, Brazil;
- Universidade Federal de Minas Gerais (BR)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-03-10
- Volume
- 106
- Issue
- 10
- Pages
- 4018-4023
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2656197
- OpenAlex
- W2026927834
- Cited by
- 318
- References
- 31
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 11 · 2023: 18 · 2022: 9 · 2021: 11 · 2020: 14 · 2019: 19 · 2018: 8 · 2017: 18 · 2016: 20 · 2015: 12 · 2014: 18 · 2013: 23 · 2012: 24
- FWCI
- 20.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- TLR2, polymicrobial sepsis, neutrophil migration, CXCR2, chemokine receptor down-regulation, lipoteichoic acid, G protein-coupled receptor kinase 2, actin polymerization, bacterial clearance, inflammatory cytokines
- MeSH terms
- Animals, Cell Movement, Chemotaxis, Gene Expression Regulation, Immunity, Innate, Lipopolysaccharides, Neutrophils, Peritonitis, Teichoic Acids, Signal Transduction, Down-Regulation, Survival Analysis, Sepsis, Receptors, Interleukin-8B, Toll-Like Receptor 2, Mice, G-Protein-Coupled Receptor Kinase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
