HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038

A Perivascular Niche for Brain Tumor Stem Cells

Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,253

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

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Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor

Bao, S., Wu, Q., Sathornsumetee, S., Hao, Y., Li, Z., Hjelmeland, A. B., Shi, Q., McLendon, R. E., Bigner, D. D., & Rich, J. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1010 · Cited by 1,347

Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179

Hypoxia requires Notch signaling to maintain the undifferentiated cell state

Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.010 · Cited by 1,109

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

Appelhoff, R. J., Tian, Y.-M., Raval, R. R., Turley, H., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., & Gleadle, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406026200 · Cited by 1,108

HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C., Labosky, P. A., Simon, M. C., & Keith, B. (2006) · Genes & Development · doi:10.1101/gad.1399906 · Cited by 850

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.Preprint

Ishibashi, M., Ang, S., Shiota, K., Nakanishi, S., Kageyama, R., & Guillemot, F. (1995) · Genes & Development · doi:10.1101/gad.9.24.3136 · Cited by 767

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.026 · Cited by 735

Wnt/BMP Mediated Metabolic Reprogramming Preserves Multipotency of Neural Crest-Like Stem Cells

Mehrotra, P., Ikhapoh, I. A., Lei, P., Tseropoulos, G., Zhang, Y., Wang, J., Liu, S., Bronner-Fraser, M. E., & Andreadis, S. T. (2023) · Stem Cells · doi:10.1093/stmcls/sxad001 · Cited by 11

MicroRNAs as prospective biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma

Андреева, Н. А., Usman, N. Y., & Druy, A. E. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08137-y · Cited by 11

Hemangioblastoma Stromal Cells Show Committed Stem Cell Phenotype

Welten, C. M., Keats, E. C., Ang, L.-C., & Khan, Z. A. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100015675 · Cited by 10

Epithelial-Mesenchymal Transition in Tumor Microenvironment Induced by Hypoxia

Eskiizmir, G., & Özgür, E. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.78717 · Cited by 11

Tumor-Initiating Cells in Childhood Neuroblastoma—Letter

Mohlin, S., Pietras, A., Wigerup, C., Øra, I., Andäng, M., Nilsson, K., Olofsson, T., Gisselsson, D., & Påhlman, S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1761 · Cited by 10

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

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Natural killer cell-based therapies in neuroblastoma

Ghasempour, A., Mohseni, R., Sharif, P. M., & Hamidieh, A. A. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104898 · Cited by 8

EPAS1/HIF2α correlates with features of low-risk neuroblastoma and with adrenal chromaffin cell differentiation during sympathoadrenal development

Westerlund, I., Shi, Y., & Holmberg, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.076 · Cited by 8

New prognostic markers in neuroblastoma

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HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics

Bechmann, N., Westermann, F., & Eisenhofer, G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1022192 · Cited by 7

Tumour Hypoxia and the Hypoxia-Inducible Transcription Factors: Key Players in Cancer Progression and Metastasis

Jögi, A. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1824-5_4 · Cited by 7

The Role of Cancer Stem Cells in Tumor Radioresistance

Kurth, I., Peitzsch, C., Baumann, M. A., & Dubrovska, A. (2014) · Wiley eBooks · doi:10.1002/9781118356203.ch35 · Cited by 7

The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling

Kasemeier‐Kulesa, J. C., Spengler, J. A., Muolo, C. E., Morrison, J. A., Woolley, T. E., Schnell, S. D., & Kulesa, P. M. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.08.007 · Cited by 6

Downregulation of OCT4 promotes differentiation and inhibits growth of BE (2)-C human neuroblastoma I-type cells

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Reply to Mohlin et al.: High levels of EPAS1 are closely associated with key features of low-risk neuroblastoma

Westerlund, I., Shi, Y., Toskas, K., Fell, S. M., Li, S., Södersten, E., Schlisio, S., & Holmberg, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718429115 · Cited by 5

Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma

Chaves, G. S., Chennakesavalu, M., Moore, K., Adams, H., Chittenden, C., Wilkinson, E., Vayani, O. R., Kaufman, M. E., Chlenski, A., He, C., et al. (2026) · Clinical and Translational Science · doi:10.1111/cts.70508 · Cited by 3

Retinoic-Acid-Induced Downregulation of the 67 KDa Laminin Receptor Correlates with Reduced Biological Aggressiveness of Human Neuroblastoma Cells

Juan, M., Buerl, C., Lpez, C. M. R., Satu, P., Navarro, S., & Barettino, D. (2012) · InTech eBooks · doi:10.5772/27102 · Cited by 3

Serum hypoxia‐inducible factor‐2: A candidate prognostic biomarker for laryngeal cancer

Eskiizmir, G., Calibasi‐Kocal, G., Uysal, T., Ellıdokuz, H., & Baspinar, Y. (2021) · Clinical Otolaryngology · doi:10.1111/coa.13789 · Cited by 3

Cancer Stem Cells

Buczacki, S. J. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30119-5 · Cited by 3

Cancer Stem Cells

Darvish-Damavandi, M., Zhou, Y., & Buczacki, S. J. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00076-6 · Cited by 3

Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis

Svensson, K. J. (2012) · Lund University Publications (Lund University) · Cited by 2

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma

Yuan, J., Maitra, S., Antoniou, E., Zhu, J., Li, W., Demirel, I. S., Toskas, K., Martinez, I. L., Ozcimen, L., Lindehell, H., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2516922122 · Cited by 1

Stem Cell Pathways in Brain Tumors

Lathia, J. D., Li, M., Bonnamain, V., & Rich, J. N. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3801-4_13 · Cited by 1

Tumor-Initiating Cells in Childhood Neuroblastoma—Response

Hansford, L. M., & Kaplan, D. R. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3548 · Cited by 1

The role of Notch signaling in cancer and metastasis

Mutvei, A. P. (2014) · Figshare · Cited by 1

Cancer-associated HIF-2α impacts trunk neural crest stemnessPreprint

Mohlin, S., Persson, C. U., Fredlund, E., Monni, E., Lindvall, J. M., Kokaia, Z., Hammarlund, E. U., & Bronner-Fraser, M. E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.22.915199 · Cited by 1

Cancer Stem Cells: Paradigm Shifting or Perishing Concept?

Pazhanisamy, S. K., & Chan, K. S. (2011) · Springer eBooks · doi:10.1007/978-94-007-2801-1_7

Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment

Gershan, J. A., Chan, A. M.-L., Chrzanowska‐Wodnicka, M., Johnson, B. D., Robert, Q., & Ramchandr, R. (2013) · InTech eBooks · doi:10.5772/55486 · Cited by 1

Research approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

Fardin, P., Barla, A., Mosci, S., Rosasco, L., Verri, A., Versteeg, R., Caron, H. N., Molenaar, J. J., Øra, I., Eva, A., et al. (2010)

CALL FOR PAPERS: Translational Research in Acute Lung Injury and Pulmonary Fibrosis miR-210 promotes IPF fibroblast proliferation in response to hypoxia

Bodempudi, V., Hergert, P. J., Smith, K. A., Hong, X., Herrera, J., Peterson, M. S., Khalil, W., Kahm, J., Bitterman, P. B., & Henke, C. A. (2014)

Role of Stemness Factors in Neuroblastoma

Stafman, L. L., Aye, J. M., & Beierle, E. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812005-7.00011-4

Genetics, Biology, Clinical Presentation, Laboratory Diagnostics, and Management of Pediatric and Adolescent Pheochromocytoma and Paraganglioma

Eisenhofer, G., Pamporaki, C., Kuhlen, M., & Redlich, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-37275-9_6

Rôle des facteurs de transcription HIF (Hypoxia Inducible Factor) dans le maintien à long terme des cellules souches hématopoïétiques humaines chez la souris immunodéficiente

Rouault-Pierre, K. (2010) · theses.fr (ABES) · doi:10.70675/d19021d9z37c5z4948zb727z5f042b13da9d

Role of VDAC1 hypoxic form, VDAC1-∆C, in the expression of primary cilia and tumor progression

Fabbri, L. (2019) · theses.fr (ABES) · doi:10.70675/7a53239dzc652z4ea4z8b95z4a71961c83b4

Impact du ciblage du domaine de liaison de HIF-1α avec HIF-1β sur le paysage immunitaire du mélanome

Lequeux, A. (2020) · theses.fr (ABES) · doi:10.70675/a29d12dbz79c1z4d37za978z2e2319131c82

Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

Pietras, A. (2010) · Lund University Publications (Lund University)

HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia

Nilsson, H., Jögi, A., Beckman, S., Harris, A. L., Poellinger, L., & Påhlman, S. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.003 · Cited by 75

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.026 · Cited by 735

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

Jögi, A., Øra, I., Nilsson, H., Lindeheim, Å., Makino, Y., Poellinger, L., Axelson, H., & Påhlman, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102660199 · Cited by 399

High levels of HIF‐2α highlight an immature neural crest‐like neuroblastoma cell cohort located in a perivascular niche

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