Cited by 135Neuroblastoma Research and TreatmentsCancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

Open access

Pietras, Alexander, Hansford, Loen M., Johnsson, A. Sofie, Bridges, Esther, Sjölund, Jonas, Gisselsson, David, Rehn, Matilda, Beckman, Siv, Noguera, Rosa, Navarro, Samuel, Cammenga, Jörg, Fredlund, Erik, Kaplan, David R., Påhlman, Sven·2009·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0904606106PMC PMC2745331

Open this paper in CoChat — free account

Abstract

High hypoxia-inducible factor-2α (HIF-2α) protein levels predict poor outcome in neuroblastoma, and hypoxia dedifferentiates cultured neuroblastoma cells toward a neural crest-like phenotype. Here, we identify HIF-2α as a marker of normoxic neural crest-like neuroblastoma tumor-initiating/stem cells (TICs) isolated from patient bone marrows. Knockdown of HIF-2α reduced VEGF expression and induced partial sympathetic neuronal differentiation when these TICs were grown in vitro under stem cell-promoting conditions. Xenograft tumors of HIF-2α-silenced cells were widely necrotic, poorly vascularized, and resembled the bulk of tumor cells in clinical neuroblastomas by expressing additional sympathetic neuronal markers, whereas control tumors were immature, well-vascularized, and stroma-rich. Thus, HIF-2α maintains an undifferentiated state of neuroblastoma TICs. Because low differentiation is associated with poor outcome and angiogenesis is crucial for tumor growth, HIF-2α is an attractive target for neuroblastoma therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0904606106

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
A Perivascular Niche for Brain Tumor Stem Cells
Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,253
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
Li, Z., Bao, S., Wu, Q., Wang, H., Eyler, C., Sathornsumetee, S., Shi, Q., Cao, Y., Lathia, J., McLendon, R. E., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.018 · Cited by 1,354
Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor
Bao, S., Wu, Q., Sathornsumetee, S., Hao, Y., Li, Z., Hjelmeland, A. B., Shi, Q., McLendon, R. E., Bigner, D. D., & Rich, J. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1010 · Cited by 1,347
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.010 · Cited by 1,109
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
Appelhoff, R. J., Tian, Y.-M., Raval, R. R., Turley, H., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., & Gleadle, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406026200 · Cited by 1,108
HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint
Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C., Labosky, P. A., Simon, M. C., & Keith, B. (2006) · Genes & Development · doi:10.1101/gad.1399906 · Cited by 850
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.Preprint
Ishibashi, M., Ang, S., Shiota, K., Nakanishi, S., Kageyama, R., & Guillemot, F. (1995) · Genes & Development · doi:10.1101/gad.9.24.3136 · Cited by 767
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.026 · Cited by 735
Self-citation

Show all 32 references

Sorted by citations

Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687
“Furthermore, HIF-1α loss decreases tumor vascularization and impairs vascular function (Carmeliet et al., 1998), and HIF-2α knockdown in glioblastoma and neuroblastoma results in poorly vascularized tumors (Li et al., 2009; Pietras et al., 2009).”
BackgroundSelf-citation
Passing the baton: the HIF switch
Koh, M. Y., & Powis, G. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.004 · Cited by 589
Molecular targeting therapies for neuroblastoma: Progress and challenges
Zafar, A., Wang, W., Liu, G., Wang, X., Xian, W., McKeon, F., Foster, J. H., Zhou, J., & Zhang, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21750 · Cited by 388
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
Scheuermann, T. H., Li, Q., Ma, H.-W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1185 · Cited by 315
HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
Qiang, L., Wu, T., Zhang, H.-W., Lu, N., Hu, R., Wang, Y.-J., Zhao, L., Chen, F.-H., Wang, X.-T., You, Q.-D., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.95 · Cited by 313
Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment
Lathia, J. D., Heddleston, J. M., Venere, M., & Rich, J. N. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.013 · Cited by 269
Oxidative stress, redox regulation and diseases of cellular differentiation
Ye, Z., Zhang, J., Townsend, D. M., & Tew, K. D. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.11.010 · Cited by 271
Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting
Huang, Z., Cheng, L., Guryanova, O. A., Wu, Q., & Bao, S. (2010) · Protein & Cell · doi:10.1007/s13238-010-0078-y · Cited by 248
Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer
Shanmugam, M. K., Warrier, S. R., Kumar, A. P., Sethi, G., & Arfuso, F. (2017) · Current Vascular Pharmacology · doi:10.2174/1570161115666170713094319 · Cited by 214
SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
Cui, C., Wong, C. C., Kai, A. K., Ho, D. W., Lau, E. Y.-T., Tsui, Y., Chan, L., Cheung, T. T., Chok, K., Chan, A. C. Y., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313264 · Cited by 210
Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors
Jögi, A., Vaapil, M., Johansson, M., & Påhlman, S. (2012) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.659294 · Cited by 209
Self-citation
Neuroblastoma
Nakagawara, A., Li, Y., Izumi, H., Muramori, K., Inada, H., & Nishi, M. (2018) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyx176 · Cited by 204
Potential therapeutic implications of cancer stem cells in glioblastoma
Cheng, L., Bao, S., & Rich, J. N. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.04.035 · Cited by 200
HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
Rouault‐Pierre, K., López-Onieva, L., Foster, K., Anjos‐Afonso, F., Lamrissi‐Garcia, I., Serrano-Sanchez, M., Mitter, R., Ivanović, Z., de Verneuil, H., Gribben, J. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.08.011 · Cited by 203
Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species
Vieira, H. L. A., Alves, P. M., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.007 · Cited by 165
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity
Liu, D., Song, L., Wei, J., Courtney, A. N., Gao, X., Marinova, E., Guo, L., Heczey, A. A., Asgharzadeh, S., Kim, E. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59535 · Cited by 164
Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells
Ahmed, N., Escalona, R. M., Leung, D. T. H., Chan, E., & Kannourakis, G. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.10.002 · Cited by 166
Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma
Sharma, R., Kadife, E., Myers, M. A., Kannourakis, G., Prithviraj, P., & Ahmed, N. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01961-3 · Cited by 179
HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways
Yan, Y., Liu, F., Han, L., Zhao, L., Chen, J., Olopade, O. I., He, M., & Wei, M. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0925-x · Cited by 167
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α
Qing, G., Skuli, N., Mayes, P. A., Pawel, B., Martinez, D., Maris, J. M., & Simon, M. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0740 · Cited by 157
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
Melzer, C., von der Ohe, J., Lehnert, H., Ungefroren, H., & Hass, R. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0595-x · Cited by 152
MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha
Zhang, H., Pu, J., Qi, T., Qi, M., Yang, C., Li, S., Huang, K., Zheng, L., & Tong, Q. (2014) · Oncogene · doi:10.1038/onc.2012.574 · Cited by 144
Hypoxia Inducible Factor Pathway Inhibitors as Anticancer Therapeutics
Burroughs, S. K., Kaluz, S., Wang, D., Wang, K., Van Meir, E. G., & Wang, B. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.17 · Cited by 140
Molecular oxygen as a signaling component in plant development
Weits, D. A., van Dongen, J. T., & Licausi, F. (2020) · New Phytologist · doi:10.1111/nph.16424 · Cited by 138
Tumor Dormancy and Cancer Stem Cells: Two Sides of the Same Coin?
Kleffel, S., & Schatton, T. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1445-2_8 · Cited by 140
In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas
Toledo, R. A., Qin, Y., Srikantan, S., Morales, N. P., Li, Q., Deng, Y., Kim, S.-W., Pereira, M. A. A., Toledo, S. P. A., Su, X., et al. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0101 · Cited by 136
Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance
Li, Z., & Rich, J. N. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_75 · Cited by 140
An ID2-dependent mechanism for VHL inactivation in cancer
Lee, S. B., Frattini, V., Bansal, M., Castano, A. M., Sherman, D., Hutchinson, K., Bruce, J. N., Califano, A., Liu, G., Cardozo, T. J., et al. (2016) · Nature · doi:10.1038/nature16475 · Cited by 132
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells
Kim, H., Lin, Q., Glazer, P. M., & Yun, Z. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0944-8 · Cited by 122
Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104
Benito, J., Shi, Y., Szymanska, B., Carol, H., Boehm, I., Lu, H., Konoplev, S. N., Fang, W., Zweidler‐McKay, P. A., Campana, D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023108 · Cited by 122
Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia‐inducible factors HIF 1α and HIF 2α
Schöning, J., Monteiro, M. J., & Gu, W. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12693 · Cited by 118
Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics
Lin, Q., & Yun, Z. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.12.12347 · Cited by 108
The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis
Myszczyszyn, A., Czarnecka, A. M., Matak, D., Szymański, Ł., Lian, F., Kornakiewicz, A., Bartnik, E., Kukwa, W., Kiéda, C., & Szczylik, C. A. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9611-y · Cited by 109
Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells
Hashimoto, O., Shimizu, K., Semba, S., Chiba, S., Ku, Y., Yokozaki, H., & Hori, Y. (2011) · Pathobiology · doi:10.1159/000325538 · Cited by 108
PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma
Mohlin, S., Hamidian, A., von Stedingk, K., Bridges, E., Wigerup, C., Bexell, D., & Påhlman, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0708 · Cited by 104
Self-citation
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
Fardin, P., Barla, A., Mosci, S., Rosasco, L., Verri, A., Versteeg, R., Caron, H. N., Molenaar, J. J., Øra, I., Eva, A., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-185 · Cited by 102
Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells
Grinshtein, N., Datti, A., Fujitani, M., Uehling, D., Prakesch, M. A., Isaac, M. B., Irwin, M. S., Wrana, J. L., Al‐awar, R., & Kaplan, D. R. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2484 · Cited by 96
Self-citation
Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition
Ng, K. P., Manjeri, A., Lee, K. L., Huang, W., Tan, S., Chuah, C. T. H., Poellinger, L., & Ong, S. T. (2014) · Blood · doi:10.1182/blood-2013-07-511907 · Cited by 96
The HIF and other quandaries in VHL disease
Tarade, D., & Ohh, M. (2017) · Oncogene · doi:10.1038/onc.2017.338 · Cited by 93
Hypoxia and Regulation of Cancer Cell Stemness
Yun, Z., & Lin, Q. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_2 · Cited by 92
Glioma Stem Cell Maintenance: The Role of the Microenvironment
Heddleston, J. M., Hitomi, M., Venere, M., Flavahan, W. A., Yang, K., Kim, Y., Minhas, S., Rich, J. N., & Hjelmeland, A. B. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797249260 · Cited by 85
miR-210 promotes IPF fibroblast proliferation in response to hypoxia
Bodempudi, V., Hergert, P. J., Smith, K. A., Hong, X., Herrera, J., Peterson, M., Khalil, W., Kahm, J., Bitterman, P. B., & Henke, C. A. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00069.2014 · Cited by 86
SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer
He, C., Danes, J. M., Hart, P. C., Zhu, Y., Huang, Y., de Abreu, A. L., O’Brien, J., Mathison, A., Tang, B., Frasor, J. M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902308116 · Cited by 83
Hypoxia and hypoxia-inducible factors in neuroblastoma
Påhlman, S., & Mohlin, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2701-1 · Cited by 85
Self-citation
Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions
Joshi, S. (2020) · Cancers · doi:10.3390/cancers12082057 · Cited by 86
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis
Chen, Y., Shao, X., Cao, J., Zhu, H., Yang, B., He, Q., & Ying, M. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.09.007 · Cited by 80
Immunosuppressive Microenvironment in Neuroblastoma
Pistoia, V., Morandi, F., Bianchi, G., Pezzolo, A., Prigione, I., & Raffaghello, L. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00167 · Cited by 78
Hif-1α and Hif-2α differentially regulate Notch signaling through competitive interaction with the intracellular domain of Notch receptors in glioma stem cells
Hu, Y., Fu, L.-A., Li, S., Chen, Y., Li, J., Han, J., Liang, L., Li, L., Ji, C., Zheng, M., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.03.035 · Cited by 75
Tumoral heterogeneity in neuroblastoma
Gomez, R. L., Ibragimova, S., Ramachandran, R., Philpott, A., & Ali, F. R. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188805 · Cited by 74
Tumour oxygenation: implications for breast cancer prognosis
Rundqvist, H., & Johnson, R. S. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12091 · Cited by 71
JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation
Pietras, A., von Stedingk, K., Lindgren, D., Påhlman, S., & Axelson, H. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0508 · Cited by 73
Self-citation
Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy
Daniele, S., Zappelli, E., Natali, L., Martini, C., & Trincavelli, M. L. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.487 · Cited by 69
Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells
Pezzolo, A., Parodi, F., Marimpietri, D., Raffaghello, L., Cocco, C., Pistorio, A., Mosconi, M., Gambini, C., Cilli, M., Deaglio, S., et al. (2011) · Cell Research · doi:10.1038/cr.2011.38 · Cited by 68
Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas
Cantilena, S., Pastorino, F., Pezzolo, A., Chayka, O., Pistoia, V., Ponzoni, M., & Sala, A. (2011) · Oncotarget · doi:10.18632/oncotarget.410 · Cited by 68
Hypoxia and cancer related pathology
Xiong, Q., Liu, B., Ding, M., Zhou, J., Yang, C., & Chen, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.002 · Cited by 71
Cellular and Molecular Mechanisms Underlying Oxygen-Dependent Radiosensitivity
Liu, C., Lin, Q., & Yun, Z. (2015) · Radiation Research · doi:10.1667/rr13959.1 · Cited by 63
Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin
He, M., Wu, H., Jiang, Q., Liu, Y., Han, L., Yan, Y., Wei, B., Liu, F., Deng, X., Chen, H., et al. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12419 · Cited by 60
The HIF-2α-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization
Pietras, A., Johnsson, A. S., & Påhlman, S. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_72 · Cited by 62
Self-citation
Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression
Westerlund, I., Shi, Y., Toskas, K., Fell, S. M., Li, S., Surova, O. V., Södersten, E., Kogner, P., Nyman, U., Schlisio, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700655114 · Cited by 58
Adrenal medulla development and medullary-cortical interactions
Bechmann, N., Berger, I., Bornstein, S. R., & Steenblock, C. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111258 · Cited by 58
EMT and Stem Cell-Like Properties Associated with HIF-2α Are Involved in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells
Xu, Y., Li, Y., Pang, Y., Ling, M., Shen, L., Yang, X., Zhang, J., Zhou, J., Wang, X., & Liu, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037765 · Cited by 47
Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
Garner, E. F., & Beierle, E. A. (2015) · Cancers · doi:10.3390/cancers8010005 · Cited by 48
Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry
Andreucci, E., Peppicelli, S., Ruzzolini, J., Bianchini, F., & Calorini, L. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10067-x · Cited by 44
HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
Tarade, D., Robinson, C. M., Lee, J. E., & Ohh, M. (2018) · Nature Communications · doi:10.1038/s41467-018-05554-1 · Cited by 44
Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment
Hu, J., Yin, Z., Shen, W., Xie, Y., Zhu, T., Lü, P., Cai, Y., Kong, M., Heng, B. C., Zhou, Y., et al. (2016) · Stem Cells · doi:10.1002/stem.2306 · Cited by 43
Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes
Urrutia, A. A., Afzal, A., Nelson, J., Davidoff, O., Gross, K. W., & Haase, V. H. (2016) · Blood · doi:10.1182/blood-2016-05-713545 · Cited by 44
The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models
Tadić, V., Zhang, W., & Brozović, A. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189052 · Cited by 43
Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features
Richter, S., Qin, N., Pacak, K., & Eisenhofer, G. (2013) · Advances in Pharmacology · doi:10.1016/b978-0-12-411512-5.00014-2 · Cited by 42
Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part II
Wilczynski, J., Duechler, M., & Czyz, M. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0132-3 · Cited by 41
Hypoxia inducible factor‐2α importance for migration, proliferation, and self‐renewal of trunk neural crest cells
Niklasson, C. U., Fredlund, E., Monni, E., Lindvall, J. M., Kokaia, Z., Hammarlund, E. U., Bronner-Fraser, M. E., & Mohlin, S. (2020) · Developmental Dynamics · doi:10.1002/dvdy.253 · Cited by 42
Self-citation
ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma
Persson, C. U., von Stedingk, K., Fredlund, E., Bexell, D., Påhlman, S., Wigerup, C., & Mohlin, S. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111845 · Cited by 37
Self-citation
Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients
Applebaum, M. A., Jha, A. R., Kao, C., Hernandez, K. M., DeWane, G., Salwen, H. R., Chlenski, A., Dobratic, M., Mariani, C. J., Godley, L. A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12713 · Cited by 42
WNT signaling, the development of the sympathoadrenal–paraganglionic system and neuroblastoma
Becker, J., & Wilting, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2685-8 · Cited by 38
Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fraction
Wu, C., Du, H.-D., Gong, H., LI, D.-W., Tao, L., Tian, J., & Zhou, L. F. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2307 · Cited by 38
TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival
Chavali, P. L., Saini, R. K. R., Zhai, Q., Vizlin‐Hodzic, D., Venkatabalasubramanian, S., Hayashi, A., Johansson, E., Zeng, Z.-J., Mohlin, S., Påhlman, S., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.449 · Cited by 35
Self-citation
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
Castaño, C. H., Gómez-Muñoz, M. A., Pardal, R., & Vega, F. M. D. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010039 · Cited by 34
Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
Cimmino, F., Pezone, L., Avitabile, M., Acierno, G., Andolfo, I., Capasso, M., & Iolascon, A. (2015) · Scientific Reports · doi:10.1038/srep11158 · Cited by 31
microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5′-untranslated region in neuroblastoma
Qu, H., Zheng, L., Song, H., Jiao, W., Li, D., Fang, E., Wang, X., Mei, H., Pu, J., Huang, K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9813 · Cited by 32
The interplay between the cellular hypoxic response and Notch signaling
Landor, S. K.-J., & Lendahl, U. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.030 · Cited by 33
Neuroblastoma therapy: what is in the pipeline?
Veríssimo, C. S., Molenaar, J. J., Fitzsimons, C. P., & Vreugdenhil, E. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0251 · Cited by 33
MiR-526b-3p Attenuates Breast Cancer Stem Cell Properties and Chemoresistance by Targeting HIF-2α/Notch Signaling
Liu, J., Li, W., Yang, Y., Qi, Y.-B., Cheng, Y. S., & Wu, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.696269 · Cited by 29
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells
Daniele, S., Pietrobono, D., Costa, B., Giustiniano, M., Pietra, V. L., Giacomelli, C., Regina, G. L., Silvestri, R., Taliani, S., Trincavelli, M. L., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00023 · Cited by 31
HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma
Zhuang, Z., Yang, C., Ryška, A., Ji, Y., Hou, Y., Graybill, S. D., Bullova, P., Lubensky, I. A., Klöppel, G., & Pacák, K. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0148 · Cited by 28
Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research
Sharma, R., Yadav, J., Bhat, S. A., Musayev, A., Myrzagulova, S., Sharma, D., Padha, N., Saini, M., Tuli, H. S., & Singh, T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04680-w · Cited by 29
Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact
Rouault‐Pierre, K., Hamilton, A., & Bonnet, D. A. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1133582 · Cited by 29
A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression
Kim, H., Cho, Y., Kim, H. S., Kang, D., Cheon, D., Kim, Y., Chang, M. J., Lee, K. M., Chang, C. B., Kang, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18817-7 · Cited by 31
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types
Mutvei, A. P., Landor, S. K.-J., Fox, R., Braune, E.-B., Tsoi, Y. L., Phoon, Y. P., Sahlgren, C., Hartman, J., Bergh, J. C. S., Jin, S., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0400-3 · Cited by 26
Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development
Broeker, K. A. E., Steppan, D., Fuchs, M., Wagner, C., Willam, C., Kurtz, A., & Kurt, B. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.03.014 · Cited by 25
Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
Tarade, D., Lee, J. E., & Ohh, M. (2019) · Nature Communications · doi:10.1038/s41467-019-11149-1 · Cited by 21
Active Role of the Necrotic Zone in Desensitization of Hypoxic Macrophages and Regulation of CSC-Fate: A hypothesis
Mehrabi, M., Amini, F., & Mehrabi, S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00235 · Cited by 24
Prokineticin signaling is required for the maintenance of a de novo population of c-KIT+ cells to sustain neuroblastoma progression
Lau, S.-T., Hansford, L. M., Chan, W., Chan, G., Wan, T. S.-K., Wong, K. K., Kaplan, D. R., Tam, P., & Ngan, E. (2014) · Oncogene · doi:10.1038/onc.2014.24 · Cited by 19
Self-citation
Endocrine targets of hypoxia-inducible factors
Lee, H.-C., & Tsai, S. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0653 · Cited by 22
Histone acetyltransferase 1 (HAT1) acetylates hypoxia-inducible factor 2 alpha (HIF2A) to execute hypoxia response
Kumar, N., Mondal, M., Arathi, B. P., Sundaresan, N. R., & Somasundaram, K. (2022) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2022.194900 · Cited by 19
Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting
Farina, A. R., Cappabianca, L. A., Zelli, V., Sebastiano, M., & Mackay, A. R. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i7.685 · Cited by 19
Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression
Krueger, K., Catanese, L., Sciesielski, L. K., Kirschner, K. M., & Scholz, H. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.11.003 · Cited by 14
Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV
Wang, P.-Y., Currier, M. A., Hansford, L. M., Kaplan, D. R., Chiocca, E. A., Uchida, H., Goins, W. F., Cohen, J. B., Glorioso, J. C., Kuppevelt, T. H. V., et al. (2012) · Gene Therapy · doi:10.1038/gt.2012.93 · Cited by 13
Self-citation
Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice
López‐Tello, J., Kiu, R., Schofield, Z., Zhang, C. X. W., van Sinderen, D., Gall, G. L., Hall, L. J., & Sferruzzi-Perri, A. N. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102004 · Cited by 14
Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions
Lee, M.-C., Huang, H.-J., Chang, T., Huang, H.-C., Hsieh, S.-Y., Chen, Y.-S., Chou, W., Chiang, C., Lai, C., & Shiau, C.-Y. (2016) · Scientific Reports · doi:10.1038/srep29311 · Cited by 13

Authors: Pietras, A., Hansford, L. M., Johnsson, A. S., Bridges, E., Sjölund, J., Gisselsson, D., Rehn, M., Beckman, S., Noguera, R., Navarro, S., Cammenga, J., Fredlund, E., Kaplan, D. R., & Påhlman, S.
Affiliations: Lund University (SE)
University of Toronto (CA)
Departments of cClinical Genetics and
Universitat de València (ES)
ORCID: Pietras, Alexander
Bridges, Esther
Sjölund, Jonas
Gisselsson, David
Rehn, Matilda
Noguera, Rosa
Navarro, Samuel
Cammenga, Jörg
Kaplan, David R.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2009-09-29
Volume: 106
Issue: 39
Pages: 16805-16810
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0904606106
PMC: PMC2745331
OpenAlex: W1967063990
Cited by: 135
References: 32
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 11 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 14
FWCI: 8.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Neuroblastoma Research and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: HIF-2α, neuroblastoma, cancer stem cells, neural crest-like cells, hypoxia, neuronal differentiation, vascular endothelial growth factor, tumor angiogenesis, tumor necrosis, bone marrow, stem cell niche, therapeutic target
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Animals, Cell Differentiation, Female, Humans, Mice, Nude, Neural Crest, Neuroblastoma, Down-Regulation, Cell Hypoxia, Vascular Endothelial Growth Factors, Cell Line, Tumor, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks