The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
Open accessAbstract
Endogenous metals may contribute to the accumulation of amyloid plaques in Alzheimer's disease. To specifically examine the role of synaptic zinc in the plaque accumulation, Tg2576 (also called APP2576) transgenic mice ( hAPP + ) expressing cerebral amyloid plaque pathology were crossed with mice lacking zinc transporter 3 ( ZnT3 −/− ), which is required for zinc transport into synaptic vesicles. With aging, female hAPP + : ZnT3 +/+ mice manifested higher levels of synaptic zinc, insoluble amyloid β, and plaques than males; these sex differences disappeared in hAPP + : ZnT3 −/− mice. Both sexes of hAPP + : ZnT3 −/− mice had markedly reduced plaque load and less insoluble amyloid β compared with hAPP + : ZnT3 +/+ mice. Hence, of endogenous metals, synaptic zinc contributes predominantly to amyloid deposition in hAPP + mice.
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Cited by
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750
The metallobiology of Alzheimer's disease
Bush, A. I. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00067-5 · Cited by 1,315
Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158
Zinc transporters and the cellular trafficking of zinc
Eide, D. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.005 · Cited by 874
Metadata
- Authors
- Lee, J.-Y., Cole, T. B., Palmiter, R. D., Suh, S. W., & Koh, J.-Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-30
- Volume
- 99
- Issue
- 11
- Pages
- 7705-7710
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037387044
- Cited by
- 430
- References
- 11
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, J.-Y., Cole, T. B., Palmiter, R. D., Suh, S. W., & Koh, J.-Y. (2002). Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.092034699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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