Cited by 405Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

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Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

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Vlassenko, Andrei G., Vaishnavi, S. Neil, Couture, Lars, Sacco, Dana, Shannon, Benjamin J., Mach, Robert H., Morris, John C., Raichle, Marcus E., Mintun, Mark A.·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1010461107PMC PMC2955133

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Abstract

Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism. Both the Aβ plaque deposition and the changes in metabolism appear to be concentrated in the brain's default-mode network. In contrast to prior studies of brain metabolism which viewed brain metabolism from a unitary perspective that equated glucose utilization with oxygen consumption, we here report on regional glucose use apart from that entering oxidative phosphorylation (so-called "aerobic glycolysis"). Using PET, we found that the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Aβ deposition in individuals with DAT and cognitively normal participants with elevated Aβ, suggesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology.

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Authors: Vlassenko, A. G., Vaishnavi, S. N., Couture, L., Sacco, D., Shannon, B. J., Mach, R. H., Morris, J. C., Raichle, M. E., & Mintun, M. A.
Affiliations: Washington University in St. Louis (US)
Departments of aRadiology,
Neurology,
Corresponding author: Mintun, Mark A.
ORCID: Vlassenko, Andrei G.
Vaishnavi, S. Neil
Sacco, Dana
Mach, Robert H.
Morris, John C.
Raichle, Marcus E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-09-13
Volume: 107
Issue: 41
Pages: 17763-17767
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1010461107
PMC: PMC2955133
OpenAlex: W2137243283
Cited by: 404
References: 84
Citations by year: 2026: 20 · 2025: 21 · 2024: 15 · 2023: 21 · 2022: 26 · 2021: 22 · 2020: 24 · 2019: 20 · 2018: 28 · 2017: 41 · 2016: 20 · 2015: 23 · 2014: 28 · 2013: 33 · 2012: 28
FWCI: 20.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p20mh077967-04, AG05681, AG003991)
National Institute on Aging (P50AG005681, P01AG003991)
National Institute of Mental Health (P20MH-077967)
National Institute of Neurological Disorders and Stroke (F30NS057901, P30NS048056, P50NS006833)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: aerobic glycolysis, amyloid-beta deposition, Alzheimer's disease, default mode network, brain glucose metabolism, oxidative phosphorylation, spatial correlation, young adults, positron emission tomography
MeSH terms: Adult, Alzheimer Disease, Amyloid, Brain, Female, Glucose, Glycolysis, Humans, Male, Oxygen, Positron-Emission Tomography

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Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

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