The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Dual origin of mesenchymal stem cells contributing to organ growth and repair
Open accessAbstract
In many adult tissues, mesenchymal stem cells (MSCs) are closely associated with perivascular niches and coexpress many markers in common with pericytes. The ability of pericytes to act as MSCs, however, remains controversial. By using genetic lineage tracing, we show that some pericytes differentiate into specialized tooth mesenchyme-derived cells—odontoblasts—during tooth growth and in response to damage in vivo. As the pericyte-derived mesenchymal cell contribution to odontoblast differentiation does not account for all cell differentiation, we identify an additional source of cells with MSC-like properties that are stimulated to migrate toward areas of tissue damage and differentiate into odontoblasts. Thus, although pericytes are capable of acting as a source of MSCs and differentiating into cells of mesenchymal origin, they do so alongside other MSCs of a nonpericyte origin. This study identifies a dual origin of MSCs in a single tissue and suggests that the pericyte contribution to MSC-derived mesenchymal cells in any given tissue is variable and possibly dependent on the extent of the vascularity.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 3×
“Similarly, isolation of perivascular cells from tissues, based on expression of these markers and retention of MSC-like properties followed by long-term culture, has provided compelling evidence that pericytes can act as a generic source of MSCs (18, 35).”
BackgroundKern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
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Age-dependent fate and lineage restriction of single NG2 cells
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Cited by
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Regenerative endodontics: a comprehensive review
Kim, S. G., Malek, M., Sigurdsson, A., Lin, L. M., & Kahler, B. (2018) · International Endodontic Journal · doi:10.1111/iej.12954 · Cited by 523
Effect of a Calcium-silicate-based Restorative Cement on Pulp Repair
Tran, X. V., Gorin, C., Willig, C., Baroukh, B., Pellat, B., Decup, F., Opsahl Vital, S., Chaussain, C., & Boukpessi, T. (2012) · Journal of Dental Research · doi:10.1177/0022034512460833 · Cited by 277
Kobolak, J., Dinnyes, A., Memic, A., Khademhosseini, A., & Mobasheri, A. (2016) · Methods · doi:10.1016/j.ymeth.2015.09.016 · Cited by 273
Metadata
- Authors
- Feng, J., Mantesso, A., De Bari, C., Nishiyama, A., & Sharpe, P. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-04-04
- Volume
- 108
- Issue
- 16
- Pages
- 6503-6508
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2131176598
- Cited by
- 410
- References
- 7
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Feng, J., Mantesso, A., De Bari, C., Nishiyama, A., & Sharpe, P. T. (2011). Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1015449108
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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