The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Optogenetic disruption of sleep continuity impairs memory consolidation
Open accessAbstract
Memory consolidation has been proposed as a function of sleep. However, sleep is a complex phenomenon characterized by several features including duration, intensity, and continuity. Sleep continuity is disrupted in different neurological and psychiatric conditions, many of which are accompanied by memory deficits. This finding has raised the question of whether the continuity of sleep is important for memory consolidation. However, current techniques used in sleep research cannot manipulate a single sleep feature while maintaining the others constant. Here, we introduce the use of optogenetics to investigate the role of sleep continuity in memory consolidation. We optogenetically targeted hypocretin/orexin neurons, which play a key role in arousal processes. We used optogenetics to activate these neurons at different intervals in behaving mice and were able to fragment sleep without affecting its overall amount or intensity. Fragmenting sleep after the learning phase of the novel object recognition (NOR) task significantly decreased the performance of mice on the subsequent day, but memory was unaffected if the average duration of sleep episodes was maintained at 62–73% of normal. These findings demonstrate the use of optogenetic activation of arousal-related nuclei as a way to systematically manipulate a specific feature of sleep. We conclude that regardless of the total amount of sleep or sleep intensity, a minimal unit of uninterrupted sleep is crucial for memory consolidation.
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
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Selective suppression of hippocampal ripples impairs spatial memory
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The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · cited 1×
“Testing this hypothesis has been confounded by sleep deprivation methodologies which are drastic manipulations affecting the overall activity of neuronal networks, including cellular energy demand (6, 7), protein synthesis (8), levels of free radicals (9), and specific synaptic changes (10).”
BackgroundNeural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007) · Nature · doi:10.1038/nature06310 · Cited by 1,341
Self-citationSleep-Dependent Learning and Memory Consolidation
Walker, M. P., & Stickgold, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.031 · Cited by 1,113
Sleep, learning, and dreams: off-line memory reprocessing
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The REM sleep-memory consolidation hypothesis
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Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning
Graves, L. A., Heller, E. A., Pack, A. I., & Abel, T. (2003) · Learning & Memory · doi:10.1101/lm.48803 · Cited by 476
Sleep benefits subsequent hippocampal functioning
Van Der Werf, Y. D., Altena, E., Schoonheim, M. M., Sanz-Arigita, E. J., Vis, J. C., De Rijke, W., & Van Someren, E. J. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2253 · Cited by 313
Cited by
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Lim, A. S. P., Kowgier, M., Yu, L., Buchman, A. S., & Bennett, D. A. (2013) · Sleep · doi:10.5665/sleep.2802 · Cited by 793
The Restless Engram: Consolidations Never End
Dudai, Y. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150500 · Cited by 644
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T., Havekes, R., Saletin, J. M., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 552
Metadata
- Authors
- Rolls, A., Colas, D., Adamantidis, A., Carter, M., Lanre-Amos, T., Heller, H. C., & de Lecea, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-07-25
- Volume
- 108
- Issue
- 32
- Pages
- 13305-13310
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2096943065
- Cited by
- 211
- References
- 13
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- green
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