ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

Petersen, Andrew J.; Rimkus, Stacey A.; Wassarman, David A.

doi:10.1073/pnas.1110470109

Cited by 139Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

Open access

Petersen, Andrew J., Rimkus, Stacey A., Wassarman, David A.·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1110470109PMC PMC3306708

Open this paper in CoChat — free account Open PDF

Abstract

To investigate the mechanistic basis for central nervous system (CNS) neurodegeneration in the disease ataxia–telangiectasia (A-T), we analyzed flies mutant for the causative gene A-T mutated ( ATM ). ATM encodes a protein kinase that functions to monitor the genomic integrity of cells and control cell cycle, DNA repair, and apoptosis programs. Mutation of the C-terminal amino acid in Drosophila ATM inhibited the kinase activity and caused neuron and glial cell death in the adult brain and a reduction in mobility and longevity. These data indicate that reduced ATM kinase activity is sufficient to cause neurodegeneration in A-T. ATM kinase mutant flies also had elevated expression of innate immune response genes in glial cells. ATM knockdown in glial cells, but not neurons, was sufficient to cause neuron and glial cell death, a reduction in mobility and longevity, and elevated expression of innate immune response genes in glial cells, indicating that a non–cell-autonomous mechanism contributes to neurodegeneration in A-T. Taken together, these data suggest that early-onset CNS neurodegeneration in A-T is similar to late-onset CNS neurodegeneration in diseases such as Alzheimer's in which uncontrolled inflammatory response mediated by glial cells drives neurodegeneration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1110470109

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

ATM kinase inhibition in glial cells of Drosophila activated an innate immune response and elicited neurodegeneration.
“ATM kinase inhibition in glial cells of Drosophila activated an innate immune response and elicited neurodegeneration142.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [142]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,027 · see citing works
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works
The host defense of Drosophila melanogaster.
Lemaître, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,404 · see citing works
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954 · see citing works
Inflammation in neurodegenerative diseases
Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355 · see citing works
Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.Preprint
Luo, L.-Q., Liao, Y.-J., Jan, L., & Jan, Y. (1994) · Genes & Development · doi:10.1101/gad.8.15.1787 · Cited by 1,036 · see citing works
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
Ilieva, H., Polymenidou, M., & Cleveland, D. W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908164 · Cited by 1,008 · see citing works
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984 · see citing works
The Toll and Imd pathways are the major regulators of the immune response in Drosophila
Gregorio, E. D., Spellman, P. T., Tzou, P., Rubin, G. M., & Lemaître, B. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2568 · Cited by 936 · see citing works
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
Gregorio, E. D., Spellman, P. T., Rubin, G. M., & Lemaître, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221458698 · Cited by 691 · see citing works
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
Lemaître, B., Metzger, E., Michaut, L., Nicolas, E., Meister, M. F., Georgel, P., Reichhart, J., & Hoffmann, J. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9465 · Cited by 648 · see citing works
Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia
Tzou, P., Ohresser, S., Ferrandon, D., Capovilla, M., Reichhart, J., Lemaître, B., Hoffmann, J. A., & Imler, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)00072-8 · Cited by 613 · see citing works
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
McDonald, M. J., & Rosbash, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00545-1 · Cited by 606 · see citing works
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster
Werner, T., Liu, G., Kang, D., Ekengren, S. K., Steiner, H., & Hultmark, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.25.13772 · Cited by 547 · see citing works
repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system.Preprint
Xiong, W., Okano, H., Patel, N. H., Blendy, J. A., & Montell, C. (1994) · Genes & Development · doi:10.1101/gad.8.8.981 · Cited by 425 · see citing works
Glia: Initiators and progressors of pathology in Parkinson's disease
Halliday, G. M., & Stevens, C. H. (2011) · Movement Disorders · doi:10.1002/mds.23455 · Cited by 423 · see citing works
A drosomycin–GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
Ferrandon, D., Jung, A. C., Criqui, M., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1217 · Cited by 407 · see citing works
A genome-wide analysis of immune responses in Drosophila
Irving, P., Troxler, L., Heuer, T. S., Belvin, M. P., Kopczynski, C., Reichhart, J., Hoffmann, J. A., & Hétru, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261573998 · Cited by 397 · see citing works
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
Dushay, M. S., Åsling, B., & Hultmark, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10343 · Cited by 373 · see citing works
Making a better RNAi vector for Drosophila: use of intron spacers
Lee, Y. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00051-3 · Cited by 373 · see citing works
An Integrated Micro- and Macroarchitectural Analysis of the Drosophila Brain by Computer-Assisted Serial Section Electron Microscopy
Cardona, A., Saalfeld, S., Preibisch, S., Schmid, B., Cheng, A., Pulokas, J., Tomancak, P., & Hartenstein, V. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000502 · Cited by 372 · see citing works
Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain
Doherty, J., Logan, M. A., Tasdemir-Yilmaz, O. E., & Freeman, M. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5951-08.2009 · Cited by 369 · see citing works
FOXO-dependent regulation of innate immune homeostasis
Becker, T., Loch, G., Beyer, M., Zinke, I., Aschenbrenner, A. C., Carrera, P., Inhester, T., Schultze, J. L., & Hoch, M. (2010) · Nature · doi:10.1038/nature08698 · Cited by 357 · see citing works
Oxidative and Inflammatory Pathways in Parkinson’s Disease
Miller, R. L., James-Kracke, M., Sun, G. Y., & Sun, A. Y. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9656-2 · Cited by 306 · see citing works
Peripheral Glia Direct Axon Guidance across the CNS/PNS Transition Zone
Sepp, K. J., Schulte, J., & Auld, V. J. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0411 · Cited by 303 · see citing works
Emerging common themes in regulation of PIKKs and PI3Ks
Lempiäinen, H., & Halazonetis, T. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.281 · Cited by 299 · see citing works
Nuclear Translocation of Caspase-3 Is Dependent on Its Proteolytic Activation and Recognition of a Substrate-like Protein(s)
Kamada, S., Kikkawa, U., Tsujimoto, Y., & Hunter, T. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400538200 · Cited by 257 · see citing works
Multiple roles of ATM in monitoring and maintaining DNA integrity
Derheimer, F. A., & Kastan, M. B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.031 · Cited by 256 · see citing works
Nuclear initiated NF-κB signaling: nemo and ATM take center stage
Miyamoto, S. (2011) · Cell Research · doi:10.1038/cr.2010.179 · Cited by 253 · see citing works
The Swiss Cheese Mutant Causes Glial Hyperwrapping and Brain Degeneration in Drosophila
Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M., & Benzer, S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07425.1997 · Cited by 251 · see citing works
ATM and the Molecular Pathogenesis of Ataxia Telangiectasia
McKinnon, P. J. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132509 · Cited by 239 · see citing works
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
Greene, J. C., Whitworth, A. J., Andrews, L. A., Parker, T. J., & Pallanck, L. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi074 · Cited by 194 · see citing works
Morphological diversity and development of glia in Drosophila
Hartenstein, V. (2011) · Glia · doi:10.1002/glia.21162 · Cited by 172 · see citing works
Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants
Lessing, D., & Bonini, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2563 · Cited by 171 · see citing works
The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila
Fan, Y., & Bergmann, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.185 · Cited by 168 · see citing works
Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease
Morales, I., Farías, G., & Maccioni, R. B. (2010) · Neuroimmunomodulation · doi:10.1159/000258724 · Cited by 162 · see citing works
Neural Specificity of elav Expression: Defining a Drosophila Promoter for Directing Expression to the Nervous System
Yao, K., & White, K. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63010041.x · Cited by 161 · see citing works
Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin
Levashina, E. A., Ohresser, S., Lemaître, B., et al. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1705 · Cited by 138 · see citing works
The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM
Jiang, X., Sun, Y., Chen, S., Roy, K., & Price, B. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513172200 · Cited by 136 · see citing works
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
Biton, S., Barzilai, A., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.006 · Cited by 133 · see citing works
Microglia dynamics and function in the CNS
Parkhurst, C. N., & Gan, W.-B. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.002 · Cited by 132 · see citing works
Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism
Yang, Y. F., & Herrup, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4946-04.2005 · Cited by 130 · see citing works
Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair
Joyce, E. F., Pedersen, M., Tiong, S. Y. K., White-Brown, S. K., Paul, A., Campbell, S. D., & McKim, K. S. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201104121 · Cited by 123 · see citing works
Toll-like receptors are key players in neurodegeneration
Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Rodriguez‐Galán, M. C., & Iribarren, P. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.006 · Cited by 117 · see citing works
ATM protein kinase: the linchpin of cellular defenses to stress
Bhatti, S., Kozlov, S., Farooqi, A. A., Naqi, A., Lavin, M., & Khanna, K. K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0683-9 · Cited by 116 · see citing works
The Toll→NFκB Signaling Pathway Mediates the Neuropathological Effects of the Human Alzheimer's Aβ42 Polypeptide in Drosophila
Tan, L., Schedl, P. D., Song, H., Garza, D., & Konsolaki, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003966 · Cited by 110 · see citing works
Three-Dimensional Structure and Regulation of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)
Rivera-Calzada, Á., Maman, J. P., Spagnolo, L., Pearl, L. H., & Llorca, Ó. (2005) · Structure · doi:10.1016/j.str.2004.12.006 · Cited by 107 · see citing works
GATA factors participate in tissue-specific immune responses in Drosophila larvae
Senger, K., Harris, K., & Levine, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607608103 · Cited by 105 · see citing works
Multiple mechanisms limit the duration of wakefulness in Drosophila brain
Zimmerman, J. E., Rizzo, W., Shockley, K. R., Raizen, D. M., Naidoo, N. N., Mackiewicz, M., Churchill, G. A., & Pack, A. I. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00030.2006 · Cited by 104 · see citing works
Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia–telangiectasia
Kuljiš, R. O., Xu, Y., Aguila, M. C., & Baltimore, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12688 · Cited by 100 · see citing works
ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes
Liu, N., Stoica, G., Yan, M., Scofield, V. L., Qiang, W., Lynn, W. S., & Wong, P. K. Y. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700354 · Cited by 84 · see citing works
ATM and ATR Pathways Signal Alternative Splicing of Drosophila TAF1 Pre-mRNA in Response to DNA Damage
Katzenberger, R. J., Marengo, M. S., & Wassarman, D. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01125-06 · Cited by 65 · see citing works
Self-citation
Atm-Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium–Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation
Westbrook, A. M., & Schiestl, R. H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2584 · Cited by 59 · see citing works
A Novel Member of the Ig Superfamily,turtle, is a CNS-Specific Protein Required for Coordinated Motor Control
Bodily, K. D., Morrison, C. M., Renden, R., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03113.2001 · Cited by 56 · see citing works
Development‐based compartmentalization of the Drosophila central brain
Pereanu, W., Kumar, A., Jenett, A., Reichert, H., & Hartenstein, V. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22376 · Cited by 55 · see citing works
Clinical and Genetic Features of Ataxia-telangiectasia
Bundey, S. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414551821 · Cited by 55 · see citing works
Progressive ataxia in childhood with particular reference to ataxia‐telangiectasia
Sedgwick, R. P., & Boder, E. (1960) · Neurology · doi:10.1212/wnl.10.7.705 · Cited by 52 · see citing works
Elevated Serum IL-8 Levels in Ataxia Telangiectasia
McGrath‐Morrow, S. A., Collaco, J. M., Crawford, T. O., Carson, K. A., Lefton‐Greif, M. A., Zeitlin, P. L., & Lederman, H. M. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.12.007 · Cited by 46 · see citing works
Purine and folate metabolism as a potential target of sex-specific nutrient allocation in Drosophila and its implication for lifespan-reproduction tradeoff
Bauer, M. F., Katzenberger, J. D., Hamm, A. C., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00009.2006 · Cited by 43 · see citing works
ELAV
Soller, M., & White, K. (2004) · Current Biology · doi:10.1016/j.cub.2003.12.041 · Cited by 42 · see citing works
Mutations inString/CDC25inhibit cell cycle re-entry and neurodegeneration in aDrosophilamodel of Ataxia telangiectasiaPreprint
Rimkus, S. A., Katzenberger, R. J., Trinh, A. T., Dodson, G. E., Tibbetts, R. S., & Wassarman, D. A. (2008) · Genes & Development · doi:10.1101/gad.1639608 · Cited by 42 · see citing works
Self-citation
ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions
Cavalieri, S., Funaro, A., Porcedda, P., Turinetto, V., Migone, N., Gatti, R. A., & Brusco, A. (2006) · Human Mutation · doi:10.1002/humu.9454 · Cited by 39 · see citing works
Identification of the microdeletion breakpoint in aGLRA1null allele of Turkish hyperekplexia patients
Becker, K., Hohoff, C., Schmitt, B., et al. (2006) · Human Mutation · doi:10.1002/humu.9455 · Cited by 29 · see citing works
A two-tier approach to mutation detection in theCOL4A5 gene for Alport syndrome
King, K., Flinter, F. A., & Green, P. M. (2006) · Human Mutation · doi:10.1002/humu.9453 · Cited by 22 · see citing works
Molecular genetic characterization ofDrosophilaATM conserved functional domains
Pedersen, M., Tiong, S. Y. K., & Campbell, S. D. (2010) · Genome · doi:10.1139/g10-067 · Cited by 15 · see citing works

Flagged first, then by citations

Sorted by citations

Innate immune activation in neurodegenerative disease
Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437 · see citing works
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
Härtlova, A., Erttmann, S. F., Raffi, F. A., Schmalz, A. M., Resch, U., Anugula, S., Lienenklaus, S., Nilsson, L. M., Kröger, A., Nilsson, J. A., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.012 · Cited by 716 · see citing works
The role of retrotransposable elements in ageing and age-associated diseases
Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature · doi:10.1038/s41586-021-03542-y · Cited by 457 · see citing works
Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies
Onyango, I. G., Dennis, J., & Khan, S. M. (2016) · Aging and Disease · doi:10.14336/ad.2015.1007 · Cited by 260 · see citing works
Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences
Song, X., Ma, F., & Herrup, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0774-19.2019 · Cited by 133 · see citing works

Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease
Alibhai, J. D., Diack, A. B., & Manson, J. C. (2017) · Prion · doi:10.1080/19336896.2017.1378289 · Cited by 5 · see citing works
Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms
Yang, Y., & Wang, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170788 · Cited by 46 · see citing works
A Possible Neurodegeneration Mechanism Triggered by Diabetes
Farhadi, A., Vosough, M., Zhang, J., Tahamtani, Y., & Shahpasand, K. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.012 · Cited by 31 · see citing works
Temperature-Sensitive Paralytic Mutants Are Enriched For Those Causing Neurodegeneration in Drosophila
Palladino, M. J., Hadley, T. J., & Ganetzky, B. (2002) · Genetics · doi:10.1093/genetics/161.3.1197 · Cited by 98 · see citing works
Reactive oxygen species-mediated neurodegeneration is independent of the ryanodine receptor in Caernorhabditis elegans.
Young, L. E. A., & Williams, D. C. (2015) · PubMed · Cited by 3 · see citing works

Authors: Petersen, A. J., Rimkus, S. A., & Wassarman, D. A.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Wassarman, David A.
ORCID: Petersen, Andrew J.
Wassarman, David A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-02-21
Volume: 109
Issue: 11
Pages: E656-64
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1110470109
PMC: PMC3306708
OpenAlex: W1979050144
Cited by: 139
References: 68
Citations by year: 2026: 8 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 17 · 2020: 13 · 2019: 9 · 2018: 12 · 2017: 6 · 2016: 4 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 2
FWCI: 5.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (T32 GM08688, T32GM008688)
National Institute of Neurological Disorders and Stroke (R01NS059001)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: ataxia telangiectasia, ATM kinase, glial cells, neurodegeneration, innate immune response, glial cell death, non-cell autonomous neurodegeneration, Drosophila, kinase activity, neuroinflammation, aging, mobility (physical function)
MeSH terms: Animals, Brain, DNA-Binding Proteins, Drosophila melanogaster, Immunity, Innate, Longevity, Nerve Degeneration, Neuroglia, Neurons, Temperature, Up-Regulation, Cell Death, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Tumor Suppressor Proteins, Drosophila Proteins, Gene Knockdown Techniques, Ataxia Telangiectasia Mutated Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks