Cited by 566Circadian rhythm and melatoninMetabolomics and Mass Spectrometry StudiesSleep and Work-Related Fatigue

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The human circadian metabolome

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Dallmann, Robert, Viola, Antoine U., Tarokh, Leila, Cajochen, Christian, Brown, Steven A.·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1114410109PMC PMC3289302

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Abstract

The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome and diabetes. Although there is evidence that metabolism and the circadian clockwork are intimately linked on a transcriptional level, whether these effects are directly under clock control or are mediated by the rest–activity cycle and the timing of food intake is unclear. To answer this question, we conducted an unbiased screen in human subjects of the metabolome of blood plasma and saliva at different times of day. To minimize indirect effects, subjects were kept in a 40-h constant routine of enforced posture, constant dim light, hourly isocaloric meals, and sleep deprivation. Under these conditions, we found that ∼15% of all identified metabolites in plasma and saliva were under circadian control, most notably fatty acids in plasma and amino acids in saliva. Our data suggest that there is a strong direct effect of the endogenous circadian clock on multiple human metabolic pathways that is independent of sleep or feeding. In addition, they identify multiple potential small-molecule biomarkers of human circadian phase and sleep pressure.

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Authors: Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A.
Affiliations: University of Zurich (CH)
University of Basel (CH)
ORCID: Dallmann, Robert
Tarokh, Leila
Cajochen, Christian
Brown, Steven A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-01-31
Volume: 109
Issue: 7
Pages: 2625-2629
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1114410109
PMC: PMC3289302
OpenAlex: W2122927821
Cited by: 566
References: 40
Citations by year: 2026: 18 · 2025: 31 · 2024: 35 · 2023: 47 · 2022: 29 · 2021: 38 · 2020: 48 · 2019: 33 · 2018: 37 · 2017: 47 · 2016: 47 · 2015: 58 · 2014: 41 · 2013: 34 · 2012: 23
FWCI: 22.40
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
BORIS (University Library Bern) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Science Foundation
Alexander von Humboldt-Stiftung
Velux Stiftung
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Hartmann Müller-Stiftung für Medizinische Forschung
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian clock, plasma metabolites, saliva metabolites, circadian rhythm, fatty acids, amino acids, constant routine, sleep deprivation, sleep pressure
MeSH terms: Circadian Rhythm, Humans, Light, Saliva, Metabolome

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