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The human circadian metabolome
Open accessAbstract
The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome and diabetes. Although there is evidence that metabolism and the circadian clockwork are intimately linked on a transcriptional level, whether these effects are directly under clock control or are mediated by the rest–activity cycle and the timing of food intake is unclear. To answer this question, we conducted an unbiased screen in human subjects of the metabolome of blood plasma and saliva at different times of day. To minimize indirect effects, subjects were kept in a 40-h constant routine of enforced posture, constant dim light, hourly isocaloric meals, and sleep deprivation. Under these conditions, we found that ∼15% of all identified metabolites in plasma and saliva were under circadian control, most notably fatty acids in plasma and amino acids in saliva. Our data suggest that there is a strong direct effect of the endogenous circadian clock on multiple human metabolic pathways that is independent of sleep or feeding. In addition, they identify multiple potential small-molecule biomarkers of human circadian phase and sleep pressure.
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“Dallman et al. (12) found that 33 of 40 lipid species were regulated in a circadian manner, of which carnitine C12:0 overlaps with our study.”
From Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) · cites this paper as [12]
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“However, under constant routine conditions in which exogenous factors are removed or fixed, only 10–20% of metabolites appear rhythmic (5–7).”
From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [5]
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“In addition to these mouse studies, human metabolome analyses also reveal that up to 20% of detectable metabolites in matrices such as plasma and saliva exhibit daily rhythms (44)(45)(46).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [44]
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Cites
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087
Human metabolic individuality in biomedical and pharmaceutical research
CARDIoGRAM, Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., Wägele, B., Altmaier, E., Deloukas, P., Erdmann, J., et al. (2011) · Nature · doi:10.1038/nature10354 · Cited by 1,017
Circadian timing of food intake contributes to weight gain
Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953
Diagnostic Potential of Saliva: Current State and Future Applications
Pfaffe, T., Cooper-White, J. J., Beyerlein, P., Kostner, K., & Punyadeera, C. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.153767 · Cited by 805
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765
Circadian rhythms, sleep, and metabolism
Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 749
Research works printed but not linked: 1
- C Czeisler, E Brown, J Ronda, R Kronauer, A clinical method to assess the endogenous circadian phase (ECP) of the deep circadian oscillator in man. J Sleep Res 14, 295 (1985).
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Jamshed, H., Beyl, R., Della Manna, D., Yang, E., Ravussin, E., & Peterson, C. (2019) · Nutrients · doi:10.3390/nu11061234 · Cited by 664
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Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576
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Kuehnbaum, N. L., & Britz‐McKibbin, P. (2013) · Chemical Reviews · doi:10.1021/cr300484s · Cited by 371
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Ballesta, A., Innominato, P. F., Dallmann, R., Rand, D. A. J., & Lévi, F. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013441 · Cited by 348
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The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body
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Bo, S., Fadda, M., Castiglione, A., Ciccone, G., De Francesco, A., Fedele, D., Guggino, A., Parasiliti Caprino, M., Ferrara, S., Vezio Boggio, M., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.138 · Cited by 171
Kirwan, J., Brennan, L., Broadhurst, D., Fiehn, O., Cascante, M., Dunn, W. B., Schmidt, M. A., & Velagapudi, V. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.287045 · Cited by 174
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Lewis, M. R., Pearce, J. T. M., Spagou, K., Green, M., Dona, A. C., Yuen, A. H. Y., David, M., Berry, D. J., Chappell, K. E., der Sluis, V. H.-V., et al. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01481 · Cited by 152
Ang, J. E., Revell, V., Mann, A., Mäntele, S., Otway, D. T., Johnston, J. D., Thumser, A. E., Skene, D. J., & Raynaud, F. (2012) · Chronobiology International · doi:10.3109/07420528.2012.699122 · Cited by 138
Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics
Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 140
Lundell, L. S., Parr, E. B., Devlin, B. L., Ingerslev, L. R., Altıntaş, A., Sato, S., Sassone‐Corsi, P., Barrès, R., Zierath, J. R., & Hawley, J. A. (2020) · Nature Communications · doi:10.1038/s41467-020-18412-w · Cited by 135
Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation
Giskeødegård, G. F., Davies, S. K., Revell, V. L., Keun, H., & Skene, D. J. (2015) · Scientific Reports · doi:10.1038/srep14843 · Cited by 135
The circadian clock and cell cycle: interconnected biological circuits
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Ribas‐Latre, A., & Eckel‐Mahan, K. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.006 · Cited by 139
Dominoni, D. M. (2015) · Journal für Ornithologie · doi:10.1007/s10336-015-1196-3 · Cited by 135
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Zhang, D., Tong, X., Arthurs, B., Guha, A., Rui, L., Kamath, A., Inoki, K., & Yin, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567628 · Cited by 115
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases
Pan, X., Mota, S., & Zhang, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6082-8_5 · Cited by 115
Immunity's fourth dimension: approaching the circadian–immune connection
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“This ubiquity of circadian rhythms is reflected at the protein [6] and metabolite levels [7].”
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Metadata
- Authors
- Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A.
- Affiliations
- University of Zurich (CH)
- University of Basel (CH)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-01-31
- Volume
- 109
- Issue
- 7
- Pages
- 2625-2629
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3289302
- OpenAlex
- W2122927821
- Cited by
- 566
- References
- 40
- Citations by year
- 2026: 18 · 2025: 31 · 2024: 35 · 2023: 47 · 2022: 29 · 2021: 38 · 2020: 48 · 2019: 33 · 2018: 37 · 2017: 47 · 2016: 47 · 2015: 58 · 2014: 41 · 2013: 34 · 2012: 23
- FWCI
- 22.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Alexander von Humboldt-Stiftung
- Velux Stiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Hartmann Müller-Stiftung für Medizinische Forschung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, plasma metabolites, saliva metabolites, circadian rhythm, fatty acids, amino acids, constant routine, sleep deprivation, sleep pressure
- MeSH terms
- Circadian Rhythm, Humans, Light, Saliva, Metabolome
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